ChemicalBook > CAS DataBase List > 4'-Nitroacetanilide

4'-Nitroacetanilide

Product Name
4'-Nitroacetanilide
CAS No.
104-04-1
Chemical Name
4'-Nitroacetanilide
Synonyms
NSC 1315;P-NITROACETANILIDE;p-nitro-acetanilid;4-NITROACETANILIDE;4'-NITROACETANILIDE;4'-Nitroacetanilide;Acetanilide, p-nitro-;acetanilide,4’-nitro-;4-Nitroacetanilide 98%;LABOTEST-BB LT00455738
CBNumber
CB1191136
Molecular Formula
C8H8N2O3
Formula Weight
180.16
MOL File
104-04-1.mol
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4'-Nitroacetanilide Property

Melting point:
213-215 °C(lit.)
Boiling point:
312.97°C (rough estimate)
Density 
1.340
refractive index 
1.6180 (estimate)
storage temp. 
Store below +30°C.
solubility 
2.2g/l
form 
Solid
pka
13.91±0.70(Predicted)
color 
Yellow to green-yellow or green-brown
Water Solubility 
2.2g/L(room temperature)
Merck 
14,6581
BRN 
2211962
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
104-04-1(CAS DataBase Reference)
EPA Substance Registry System
Acetamide, N-(4-nitrophenyl)- (104-04-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AE5075000
TSCA 
Yes
HS Code 
29242990
Toxicity
rat,LDLo,intraperitoneal,500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 10, 1953.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.20880
Product name
4′-Nitroacetanilide
Purity
for synthesis
Packaging
25G
Price
$53.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20880
Product name
4′-Nitroacetanilide
Purity
for synthesis
Packaging
100G
Price
$204
Updated
2024/03/01
Sigma-Aldrich
Product number
130648
Product name
4-Nitroacetanilide
Purity
98%
Packaging
5g
Price
$41.6
Updated
2024/03/01
TCI Chemical
Product number
N0108
Product name
4'-Nitroacetanilide
Purity
>99.0%(GC)
Packaging
25g
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
N0108
Product name
4'-Nitroacetanilide
Purity
>99.0%(GC)
Packaging
500g
Price
$673
Updated
2024/03/01
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4'-Nitroacetanilide Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Manufacture of nitraniline.

Uses

4-Nitroacetanilide was used as a test substrate and its hydrolysis was determined by UV spectroscopic measurements. It was also used to prepare 4-aminoacetanilide.

Preparation

Preparation of 4'-Nitroacetanilide from acetanilide.
Principle: Aromatic compounds can be conveniently nitrated by the use of the nitrating mixture, which is normally a mixture of concentrated nitric acid and concentrated sulphuric acid. The function of sulphuric acid is to convert nitric acid into a highly reactive, electrophilic, nitronium ion, NO2+, which is the effective nitrating agent. Nitration of activated aromatic compounds is carried out under milder condition whereas deactivated rings require drastic conditions. Activating groups are o, p-directing, while deactivating groups are m-directing for electrophilic substitution.
Reaction:

Procedure: Take 0.5 g acetanilide in 0.6 ml glacial acetic acid and add 1 ml conc. H2SO4 in a beaker. Cool the mixture in ice salt bath (5-10°C). To this add a mixture of 0.2 ml conc. H2SO4 and 0.25 ml conc. HNO3 dropwise. Maintain the temperature below 10°C during addition. After addition is over allow the mixture to attain room temperature and leave it for 30 minutes. Pour the mixture on to crushed ice (20 g) with stirring. Filter the separated product and wash with cold water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC (using toluene as solvent).

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 5905, 1953 DOI: 10.1021/ja01119a037
Tetrahedron Letters, 28, p. 1669, 1987 DOI: 10.1016/S0040-4039(00)95389-9

Purification Methods

Precipitate the anilide from 80% H2SO4 by adding ice, then wash with water, and crystallise from aqueous EtOH. Dry it in air. [Beilstein 12 IV 1632.]

4'-Nitroacetanilide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-4-nitroaniline 5-Amino-2-nitrobenzoic acid 4'-Aminoacetanilide
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4'-Nitroacetanilide Suppliers

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View Lastest Price from 4'-Nitroacetanilide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4"-NITROACETANILIDE 104-04-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
4"-Nitroacetanilide 104-04-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4'-NITROACETANILIDE 104-04-1
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

104-04-1, 4'-NitroacetanilideRelated Search:

4-NITROPHENYLOXAMIC ACID N-Benzoyl-DL-arginine-4-nitroanilide hydrochloride N-(4-NITROPHENYL)MALEIMIDE N-(4-NITROPHENYL)PHTHALIMIDE PICROLONIC ACID N-(2-METHOXY-4-NITROPHENYL)ACETAMIDE 1-ACETYL-5-NITROINDOLINE 2,4-DINITROACETANILIDE 5-Nitroisatin 4'-Nitroacetanilide 5-Chloro-2-Nitroacetanilide ALPHA-CHLORO-3-NITROACETANILIDE,N-CHLORO-3-NITROACETANILIDE,Chloro-3-nitroacetanilide, 98% O-NITROACETANILIDE ALPHA-CHLORO-2-NITROACETANILIDE,ALPHA-CHLORO-NITROACETANILIDE,ó-chloro-2-nitroacetanilid 4-chloro-3-nitroacetanilide 4-METHOXY-3-NITROACETANILIDE 2-Methoxy-2-Nitroacetanilide,4-METHOXY-2-NITROACETANILIDE,4'-METHOXY-2'-NITROACETANILIDE 3-Nitroacetanilide, 98+%,M-NITROACETANILIDE

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