5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide

ChemicalBook > CAS DataBase List > 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide

5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide

Product Name: 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
CAS No.: 1093070-16-6
Chemical Name: 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
Synonyms: RL 0617;GRL-0617 (GRL0617;5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide;5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide;(R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide;Benzamide, 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-;GRL 0617,competitive noncovalent inhibitor,Inhibitor,GRL0617,Deubiquitinase,SARS coronavirus,inhibit,GRL-0617,DUBs,SARS-CoV
CBNumber: CB43085996
Molecular Formula: C20H20N2O
Formula Weight: 304.39
MOL File: 1093070-16-6.mol

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5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Property

Boiling point:: 514.9±50.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
form: solid
pka: 14.26±0.46(Predicted)
color: Beige
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 4575DF
Product name: 5-Amino-2-methyl-N-[2-(naphthalen-1-yl)ethyl]benzamide
Packaging: 10mg
Price: $218
Updated: 2021/12/16

ChemScene

Product number: CS-0063568
Product name: GRL0617
Purity: 99.78%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0000212
Product name: 5-AMINO-2-METHYL-N-(1R-NAPHTHALEN-1-YL-ETHYL)-BENZAMIDE
Purity: 95.00%
Packaging: 10MG
Price: $866.25
Updated: 2021/12/16

ChemScene

Product number: CS-0063568
Product name: GRL0617
Purity: 99.78%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0063568
Product name: GRL0617
Purity: 99.78%
Packaging: 50mg
Price: $2000
Updated: 2021/12/16

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5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Chemical Properties,Usage,Production

Description

GRL-0617 (1093070-16-6) is a potent (IC50?= 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0617 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50?= 15 μM).??Inactive against human DUB-like proteases HAUSP, USP18, UCH-L1, UCH-L3, and PLP2

Definition

ChEBI: GRL-0617 is a benzamide resulting from the formal condensation of the carboxy group of 5-amino-2-methylbenzoic acid with the amino group of (1R)-1-(naphthalen-1-yl)ethan-1-amine. It is a potent noncovalent inhibitor (IC50 = 600 nM) of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). It has a role as an anticoronaviral agent and a protease inhibitor. It is a member of naphthalenes, a substituted aniline, a member of benzamides and a secondary carboxamide.

storage

Store at -20°C

References

1)????Ratia?et al. (2008),?A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication;?Proc. Natl. Acad. Sci. USA,?105?16119

5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1093070-16-6, 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamideRelated Search:

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5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide

GRL-0617 (GRL0617

Benzamide, 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-

GRL 0617,competitive noncovalent inhibitor,Inhibitor,GRL0617,Deubiquitinase,SARS coronavirus,inhibit,GRL-0617,DUBs,SARS-CoV

(R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide

5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide

RL 0617

1093070-16-6