KIN1408
- Product Name
- KIN1408
- CAS No.
- 1903800-11-2
- Chemical Name
- KIN1408
- Synonyms
- KIN1408;KIN-1408 (KIN-1408;KIN1408 >=98% (HPLC);8-Quinolinol, 7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-;7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol);KIN-1408;KIN 1408;7-((4-(DIFLUOROMETHOXY)PHENYL)((5-METHOXYBENZO[D]THIAZOL-2-YL)AMINO)METHYL)QUINOLIN-8-OL
- CBNumber
- CB43121111
- Molecular Formula
- C25H19F2N3O3S
- Formula Weight
- 479.5
- MOL File
- 1903800-11-2.mol
KIN1408 Property
- Boiling point:
- 675.6±65.0 °C(Predicted)
- Density
- 1.430±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:34.5(Max Conc. mg/mL);71.95(Max Conc. mM)
- form
- A solid
- pka
- 4.22±0.50(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 21790
- Product name
- KIN1408
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 21790
- Product name
- KIN1408
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- CS-5477
- Product name
- KIN1408
- Purity
- 99.55%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 2008EG
- Product name
- 7-[[4-(Difluoromethoxy)phenyl]-[(5-methoxy-1,3-benzothiazol-2-yl)amino]methyl]quinolin-8-ol
- Packaging
- 5mg
- Price
- $201
- Updated
- 2021/12/16
- Product number
- CS-5477
- Product name
- KIN1408
- Purity
- 99.55%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
KIN1408 Chemical Properties,Usage,Production
Description
KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; ). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.
Uses
KIN1408 is an agonist of the RIG-1-like receptor (RLR) pathway and exhibits a broad-spectrum antiviral activity. KIN1408 exhibits activity against HCV, influenza A, dengue virus 2, Ebola, Nipah, and Lassa viruses[1][2].
References
[1] Green RR, et al. Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway. Genom Data. 2016 Feb 1;7:290-2. DOI:10.1016/j.gdata.2016.01.020
[2] Sowmya Pattabhi, et al. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015 Dec 16;90(5):2372-87. DOI:10.1128/JVI.02202-15
KIN1408 Preparation Products And Raw materials
Raw materials
Preparation Products
KIN1408 Suppliers
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