OBIDOXIME CHLORIDE
- Product Name
- OBIDOXIME CHLORIDE
- CAS No.
- 114-90-9
- Chemical Name
- OBIDOXIME CHLORIDE
- Synonyms
- bh6;luh6;bu-6;lueh6;D009768;Obidoxim;luh(sub6);toxobidin;TOXOGONIN;Obidoxime
- CBNumber
- CB4312572
- Molecular Formula
- C14H16Cl2N4O3
- Formula Weight
- 359.21
- MOL File
- 114-90-9.mol
OBIDOXIME CHLORIDE Property
- Melting point:
- 216-219oC dec.
- storage temp.
- -20°C Freezer
- solubility
- Methanol (Slightly), Water (Slightly)
- color
- Off-White to Light Beige
- BRN
- 4117377
- Stability:
- Stable. Incompatible with strong oxidizing agents.
Safety
- WGK Germany
- 2
- RTECS
- UU6825000
- Toxicity
- LD50 in mice, rats (mg/kg): 70, 133 i.v.; 150, 225 i.p.; >2240, >4000 orally; in mice (mg/kg): 172 i.m. (Erdman, Engelhard)
N-Bromosuccinimide Price
- Product number
- 74593
- Product name
- Obidoxime chloride
- Purity
- analytical standard
- Packaging
- 25mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 51063
- Product name
- Obidoxime chloride
- Purity
- ≥95.0% (HPLC)
- Packaging
- 1g
- Price
- $407.4
- Updated
- 2024/03/01
- Product number
- O100000
- Product name
- Obidoxime chloride
- Packaging
- 10g
- Price
- $1295
- Updated
- 2021/12/16
- Product number
- 29618
- Product name
- Obidoxime chloride
- Purity
- >95%
- Packaging
- 10g
- Price
- $2620
- Updated
- 2021/12/16
- Product number
- API0000731
- Product name
- OBIDOXIME CHLORIDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2833.1
- Updated
- 2021/12/16
OBIDOXIME CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Originator
Toksobidin,Polfa-Starogard
Uses
antibacterial
Uses
Obidoxime Chloride is a cholinesterase reactivator.
Manufacturing Process
2 Methods of producing of obidoxime chloride:
1. Into a boiling agitated solution of 2.44 g pyridine-4-aldoxime in 10 ml absolute ethanol is added dropwise during the course of 25 min a solution of 1.14 g bis-chloromethyl ether in 5 ml absolute ethanol. The reaction mixture is then refluxed for 35 min, and then agitated for 5 h at room temperature. The precipitate of bis-[4-hydroxyimino-methyl-pyridinium-(1)-methyl]-ether
Trade dichloride is thoroughly washed with absolute acetone. The yield is 3.5 g which is 98% of the theoretical, and the melting point is 229°C. If convenient, the mother liquor can be reused to make additional product.
2. 12.2 g (0.1 mole) pyridine-4-aldoxime are dissolved with heating in 125 ml chloroform. Within 25 min, 8.5 g (0.075 mole), α,α-dichlorodimethyl ether in 20 ml chloroform are dropped while stirring into the boiling solution. The reaction mixture is heated for another 35 min. After standing for several hours, the precipitate is filtered off, washed with absolute ethanol, acetone and ether and dried at 80°C. Yield: 17.0 g, 95% of the theoretical, and the melting point is 225°C (dec.).
Therapeutic Function
Antidote
General Description
active agent in Toxogonin
Biochem/physiol Actions
Antidote for organophosphate nerve agent poisoning, but, as with other oxime agents, not full spectrum. Obidoxime fails primarily to reactivate acetylcholinesterase that has been inhibited with cyclosarin.
Safety Profile
Poison by intraperitoneal,intravenous, intramuscular, and subcutaneous routes.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of Cl- and NOx. Seealso BROMIDES.
OBIDOXIME CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
OBIDOXIME CHLORIDE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from OBIDOXIME CHLORIDE manufacturers
- Product
- OBIDOXIME CHLORIDE 114-90-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25