RSL3
- Product Name
- RSL3
- CAS No.
- 1219810-16-8
- Chemical Name
- RSL3
- Synonyms
- RSL;(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate;RSL3;RSL3 1S;3R-RSL3;CS-2409;1S,3R-RSL3;RSL 3;RSL-3;RSL3 (1S,3R-);RSL3 1S;3R-;1S;3R-RSL3
- CBNumber
- CB43126772
- Molecular Formula
- C23H21ClN2O5
- Formula Weight
- 440.88
- MOL File
- 1219810-16-8.mol
RSL3 Property
- Boiling point:
- 641.3±55.0 °C(Predicted)
- Density
- 1.368±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (45 mg/ml)
- pka
- 16.09±0.60(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19288
- Product name
- (1S,3R)-RSL3
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19288
- Product name
- (1S,3R)-RSL3
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 19288
- Product name
- (1S,3R)-RSL3
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- 19288
- Product name
- (1S,3R)-RSL3
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $420
- Updated
- 2024/03/01
- Product number
- 6118
- Product name
- 1S,3R-RSL3
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $908
- Updated
- 2021/12/16
RSL3 Chemical Properties,Usage,Production
Description
RSL3 (1219810-16-8) Inhibits glutathione peroxidase (GPX4) inducing ferroptosis.1,2? Effectively induces ferroptosis in glioblastoma cells.3? Everolimus in combination with RSL3 synergistically inhibits the viability of renal cell carcinoma (RCC) cells suggesting a mechanism by which RCC drug resistance may be overcome.4
in vitro
rsl3, which was a glutathione peroxidase (gpx) 4 inhibitor, had been cooperated with the smac mimetic bv6 to induce reactive oxygen species (ros)-dependent cell death in acute lymphoblastic leukemia cells. it was found that addition of the caspase inhibitor failed to rescue ros-induced cell death, suggesting that rsl3-induced cell death occured in a caspase-independent manner. moreover, the iron chelator deferoxamine inhibited rsl3/bv6-induced cell death significantly, however, it could not rescue cell death by erastin/bv6, indicating that rsl3/bv6-, but not erastin/bv6-mediated cell death depended on iron. in addition, it was shown that ros production was required for both rsl3/bv6- and erastin/bv6-induced cell death. in contrast, genetic or pharmacological inhibition of lipid peroxidation by gpx4 overexpression significantly decreased rsl3/bv6-induced cell death. of importance, inhibition of lipid peroxidation could protect from rsl3/bv6-stimulated ros production [1].
IC 50
100 nm
storage
Store at -20°C
References
Yang et al. (2014), Regulation of ferroptotic cancer cell death by GPX4; Cell 156 317 Kagan et al. (2017), Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis; nAT. Chem. Biol. 13 81 Shengbiao et al. (2021), RSL3 Drives Ferroptosis through NF-kB Pathway Activation and GPX4 depletion in Glioblastoma; oXID. Med. Cell. Longev. 2021 2915019 Yangyun et al. (2022), Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma; Gene 809 145992
RSL3 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from RSL3 manufacturers
- Product
- RSL3 1219810-16-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kgs
- Release date
- 2019-12-17