PIK-III
- Product Name
- PIK-III
- CAS No.
- 1383716-40-2
- Chemical Name
- PIK-III
- Synonyms
- PIK-Ⅲ;PIK-III;Vps34-PIK-III;Vps34 inhibitor PIK-III;4'-(Cyclopropylmethyl)-N2-4-pyridinyl[4,5'-bipyrimidine]-2,2'-diamine;[4,5'-Bipyrimidine]-2,2'-diamine, 4'-(cyclopropylmethyl)-N2-4-pyridinyl-;4'-(Cyclopropylmethyl)-N2-(pyridin-4-yl)-[4,5'-bipyrimidine]-2,2'-diamine;4'-(Cyclopropylmethyl)-N2-(pyridin-4-yl)-[4,5'-bipyrimidine]-2,2'-diamine;PI3K,Autophagy,Vps34 PIK III,Vps-34-PIK-III,Inhibitor,Phosphoinositide 3-kinase,Vps34PIKIII,inhibit
- CBNumber
- CB43133178
- Molecular Formula
- C17H17N7
- Formula Weight
- 319.36
- MOL File
- 1383716-40-2.mol
PIK-III Property
- Boiling point:
- 657.4±65.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥31.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 6.19±0.26(Predicted)
N-Bromosuccinimide Price
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $365
- Updated
- 2024/03/01
- Product number
- 17002
- Product name
- PIK-III
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $699
- Updated
- 2024/03/01
- Product number
- AS118254
- Product name
- PIK-III
- Purity
- 98+%
- Packaging
- 25mg
- Price
- $773
- Updated
- 2021/12/16
PIK-III Chemical Properties,Usage,Production
Biological Activity
pik-iii is a vps34 inhibitor and is able to inhibit autophagy.vps34 kinase has been found to be responsible for synthesis and deposition of phosphatidylinositol-3-phosphate at autophagosome formation sites, resulting in the recruitment of ptdins(3)p-binding proteins.
in vitro
in previous study, pik-iii was identified as a selective inhibitor of vps34 binding in a hydrophobic pocket. in addition, pik-iii could acutely inhibit the autophagy and lipidation of lc3, which led to the stabilization of autophagy substrates. moreover, substrates such as ncoa4 were identified by conducting ubiquitin-affinity proteomic assay on pik-iii-treated cells, which accumulated in cells with atg7 deficience and co-localized with autolysosomes. ncoa4 could bind ferritin heavy chain-1 directly to target the iron-binding ferritin complex following starvation or iron depletion [1].
in vivo
animal study showed that pik-iii-treated ncoa4-/- mice had a profound accumulation of iron in splenic macrophages that were important for iron reutilization from engulfed red blood cells. in summary, such in vivo results provided a novel mechanism for selective autophagy of ferritin and revealed a previously untouched role for autophagy and ncoa4 in the control of in-vivo iron homeostasis [1].
IC 50
18 nm for vps34
References
[1] dowdle we et al. selective vps34 inhibitor blocks autophagy and uncovers a role for ncoa4 in ferritin degradation and iron homeostasis in vivo. nat cell biol. 2014 nov;16(11):1069-79.
PIK-III Preparation Products And Raw materials
Raw materials
Preparation Products
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