ChemicalBook > CAS DataBase List > 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
- Product Name
- 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
- CAS No.
- 1607837-31-9
- Chemical Name
- 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
- Synonyms
- CCT-251921;LM-3860,CCT251921;CCT-251921;CCT 251921;CCT-251921,Cyclin dependent kinase,Inhibitor,CDK,CCT251921,CCT 251921,inhibit;8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one;8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-2,8-Diazaspiro[4.5]decan-1-one;8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;2,8-Diazaspiro[4.5]decan-1-one, 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-
- CBNumber
- CB43133466
- Molecular Formula
- C21H23ClN6O
- Formula Weight
- 410.9
- MOL File
- 1607837-31-9.mol
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8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Property
- Boiling point:
- 696.4±55.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 28 mg/mL (68.14 mM)
- pka
- 15.81±0.20(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-5521
- Product name
- CCT-251921
- Purity
- 99.77%
- Packaging
- 1mg
- Price
- $108
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5521
- Product name
- CCT-251921
- Purity
- 99.77%
- Packaging
- 10mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5521
- Product name
- CCT-251921
- Purity
- 99.77%
- Packaging
- 25mg
- Price
- $840
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5521
- Product name
- CCT-251921
- Purity
- 99.77%
- Packaging
- 50mg
- Price
- $1140
- Updated
- 2021/12/16
Crysdot
- Product number
- CD00008621
- Product name
- CCT251921
- Purity
- 97%
- Packaging
- 50mg
- Price
- $1496
- Updated
- 2021/12/16
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8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Chemical Properties,Usage,Production
Description
CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Suppliers
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