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SirReal2

Product Name
SirReal2
CAS No.
709002-46-0
Chemical Name
SirReal2
Synonyms
SirReal2;SirReal2 >=98% (HPLC);Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
CBNumber
CB43133754
Molecular Formula
C22H20N4OS2
Formula Weight
420.55
MOL File
709002-46-0.mol
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SirReal2 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form 
A crystalline solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18116
Product name
SirReal2
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
18116
Product name
SirReal2
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
18116
Product name
SirReal2
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
18116
Product name
SirReal2
Purity
≥98%
Packaging
50mg
Price
$793
Updated
2024/03/01
Tocris
Product number
5457
Product name
SirReal2
Purity
≥98%(HPLC)
Packaging
50
Price
$664
Updated
2021/12/16
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SirReal2 Chemical Properties,Usage,Production

Description

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.

Uses

SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.

storage

Store at -20°C

SirReal2 Preparation Products And Raw materials

Raw materials

Preparation Products

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SirReal2 Suppliers

China 59 United Kingdom 1 United States 8 Global 68
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

709002-46-0, SirReal2Related Search:

Acetamide 2-Amino-4,6-dimethylpyrimidine

  • SirReal2
  • Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-
  • 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
  • 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
  • SirReal2 >=98% (HPLC)
  • Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2
  • 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
  • 709002-46-0