ChemicalBook > CAS DataBase List > N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
- Product Name
- N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
- CAS No.
- 1210608-43-7
- Chemical Name
- N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
- Synonyms
- PIM447;EOS-60671;PIM447 (LGH447);PIM447 (LGH447) Free Base;N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide;2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-
- CBNumber
- CB43143070
- Molecular Formula
- C24H23F3N4O
- Formula Weight
- 440.46
- MOL File
- 1210608-43-7.mol
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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Property
- Boiling point:
- 493.7±45.0 °C(Predicted)
- Density
- 1.290±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:88.0(Max Conc. mg/mL);199.79(Max Conc. mM)
Ethanol:88.0(Max Conc. mg/mL);199.79(Max Conc. mM) - form
- Solid
- pka
- 1.35±0.70(Predicted)
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- P446750
- Product name
- PIM447
- Packaging
- 0.25mg
- Price
- $185
- Updated
- 2021/12/16
TRC
- Product number
- P446750
- Product name
- PIM447
- Packaging
- 2.5mg
- Price
- $1025
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN19123
- Product name
- PIM-447
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Chemical Properties,Usage,Production
Uses
PIM kinases promote growth and survival of tumor cells and are expressed in a wide variety of human cancers. These kinases are potential therapeutic targets. PIM447 is a PIM kinase inhibitor.
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Preparation Products And Raw materials
Raw materials
Preparation Products
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N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide Suppliers
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