Irisin (human recombinant) Property

Melting point:

150 °C

Safety

HS Code 

3504009000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

Irisin (human recombinant) Chemical Properties,Usage,Production

Description

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function. Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure. The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.