Luotonin F Property

Boiling point:

542.0±42.0 °C(Predicted)

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

≤2.5mg/ml in DMSO;2.5mg/ml in dimethyl formamide

form 

crystalline solid

pka

2.06±0.11(Predicted)

Hazard and Precautionary Statements (GHS)

Luotonin F Chemical Properties,Usage,Production

Biological Activity

luotonin f is an alkaloid found in the aerial parts of the peganum nigellastrum bunge, a plant which has been long used in traditional chinese medicine for the treatment of rheumatism, abscesses, and various other inflammatory conditions [1].due to their biological and pharmaceutical activities, many synthetic methods have been developed for the synthesis of luotonins. an efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin f from easily available starting materials. through the rational logical design, multifundamental reactions were assembled in one-pot, such as iodination, kornblum oxidation, and annulations [2]. the developed approach could efficiently synthesize luntonin f and various analogues. luotonin f showed promising cytotoxicity against leukemia p-388 cells with an ic50 value of 2.3 μg/ml by stabilizing the dna topoisomerase i-dna complex [1].

References

[1] liang j l, cha h c, jahng y. recent advances in the studies on luotonins[j]. molecules, 2011, 16(6): 4861-4883.
[2] zhu y, fei z, liu m, et al. direct one-pot synthesis of luotonin f and analogues via rational logical design[j]. organic letters, 2012, 15(2): 378-381.