ONO-8130
- Product Name
- ONO-8130
- CAS No.
- 459841-96-4
- Chemical Name
- ONO-8130
- Synonyms
- ONO-8130;4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid;Benzoic acid, 4-[[[2,3-dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-inden-5-yl]oxy]methyl]-;Orally active,ONO8130,Inhibitor,inhibit,Bladder pain,ONO 8130,Prostaglandin Receptor,Interstitial cystitis,PKR-like endoplasmic reticulum kinase,PERK,Hyperalgesia,Protein kinase R-like endoplasmic reticulum kinase,ONO-8130
- CBNumber
- CB43152708
- Molecular Formula
- C25H28N2O5S2
- Formula Weight
- 500.63
- MOL File
- 459841-96-4.mol
ONO-8130 Property
- Boiling point:
- 705.1±70.0 °C(Predicted)
- Density
- 1.344±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤2mg/ml in ethanol;3mg/ml in DMSO;1mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 4.17±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 19118
- Product name
- ONO-8130
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $43
- Updated
- 2024/03/01
- Product number
- 19118
- Product name
- ONO-8130
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 19118
- Product name
- ONO-8130
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 19118
- Product name
- ONO-8130
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $621
- Updated
- 2024/03/01
- Product number
- 5406
- Product name
- ONO8130
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1081
- Updated
- 2021/12/16
ONO-8130 Chemical Properties,Usage,Production
Uses
ONO 8130 is a selective prostanoid EP1 receptor antagonist, which relieves bladder pain in mice with cyclophosphamide-induced cystitis.
Biological Activity
ono-8130 is an orally bioavailable and selective antagonist of the prostaglandin e2 (pge2) receptor ep1 with ki value of 1.9 nm [1][2][3].prostaglandins contribute to the sensitization of peripheral and central nociceptive neurons during peripheral inflammation. prostaglandin e2 (pge2) is considered a dominant pronociceptive prostanoid. pge2 receptors are g protein-coupled receptors and classified into 4 general subtypes (ep1, ep2, ep3, and ep4) that are located unevenly in different tissues. ep1 receptors play a major role in processing of pain [1].in cystitis-related bladder pain mice, oral preadministration of ono-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent way. ono-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain. ono-8130 also blocked prostaglandin e2 caused prompt phosphorylation of erk in the l6 spinal cord [1]. in the guinea pig trachea (gpt), ono-8130 inhibited the initial contraction mediated by pge2. ono-8130 also eliminated the spontaneous tone [2].
storage
Store at +4°C
References
[1]. miki t, matsunami m, nakamura s, et al. ono-8130, a selective prostanoid ep1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. pain. 2011 jun;152(6):1373-81.
[2]. sfholm j, dahlén se, adner m. antagonising ep1 and ep2 receptors reveal that the tp receptor mediates a component of antigen-induced contraction of the guinea pig trachea. eur j pharmacol. 2013 oct 15;718(1-3):277-82.