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IDO-IN-2

Product Name
IDO-IN-2
CAS No.
1668565-74-9
Chemical Name
IDO-IN-2
Synonyms
DO-IN-2;PCC0208009;IDO inhibitor 2;PCC0208009, 10 mM in DMSO;1-(4-(diisobutylamino)-2'-(1H-tetrazol-5-yl)biphenyl-3-yl)-3-p-tolylurea;1-(4-(Diisobutylamino)-2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)urea;Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)-;PCC0208009,IDO,PCC-0208009,Inhibitor,Indoleamine 2,3-Dioxygenase (IDO),PCC 0208009,inhibit,neuropathic
CBNumber
CB43156650
Molecular Formula
C29H35N7O
Formula Weight
497.63
MOL File
1668565-74-9.mol
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IDO-IN-2 Property

Density 
1.206±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form 
A solid
pka
4.17±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6165
Product name
PCC0208009
Purity
99.65%
Packaging
2mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-6165
Product name
PCC0208009
Purity
99.65%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-6165
Product name
PCC0208009
Purity
99.65%
Packaging
10mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-6165
Product name
PCC0208009
Purity
99.65%
Packaging
50mg
Price
$590
Updated
2021/12/16
DC Chemicals
Product number
DC10421
Product name
IDO-IN-2
Purity
>98%
Packaging
100mg
Price
$650
Updated
2021/12/16
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IDO-IN-2 Chemical Properties,Usage,Production

Uses

PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala [1][2].

in vivo

PCC0208009 (single oral gavage; 50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 60, 120 and 240 min after drug administration in plasma and brain samples, and the highest concentrations of PCC0208009 in plasma and brain are observed at 60 min after administration. Concomitantly, the Kyn/Trp ratio decreases at 60, 120 and 240 min postdose, with the minimum level in the plasma and the brain seen at 60 min post-dose[1].
PCC0208009 (oral gavage; once; 12-50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 30, 60 and 90min after administration to evaluate the antinociceptive effects of PCC0208009 on neuropathic pain[1].

Animal Model:Adult male Sprague Dawley rats (180 g-200 g) [1]
Dosage:50 mg/kg
Administration:Single oral gavage
Result:The highest concentrations of PCC0208009 in plasma and brain were observed at 60 min after administration.
Animal Model:Adult male Sprague-Dawley rats bearing spinal nerve ligation (SNL)[1]
Dosage:12.5 mg/kg, 25 mg/kg, 50 mg/kg
Administration:oral gavage; once
Result:Showed the behavioral tests and the timelines.

IC 50

IDO: 4.52 nM (IC50, in HeLa cell)

References

[1] Yu Wang, et al. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem Pharmacol. 2020 Jul;177:113926. DOI:10.1016/j.bcp.2020.113926
[2] David K Williams, et al. Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg Med Chem Lett. 2018 Feb 15;28(4):732-736. DOI:10.1016/j.bmcl.2018.01.010
[3] Shanyue Sun, et al. PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models. Int J Immunopathol Pharmacol. Jan-Dec 2018;32:2058738418787991. DOI:10.1177/2058738418787991

IDO-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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IDO-IN-2 Suppliers

China 58 India 1 United States 5 Global 64
DKMbiochem.Co. Ltd
Tel
15901859516
Fax
15901859516
Email
sales@DKMbiochem.com
Country
China
ProdList
344
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58
Deyang Yuehe Bio-Pharmaceutical Co.,Ltd
Tel
028-82729560 18030702676
Fax
028-82729560
Email
sales@yuehepharm.com
Country
China
ProdList
179
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
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58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12476
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58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9751
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58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
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58
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View Lastest Price from IDO-IN-2 manufacturers

Career Henan Chemical Co
Product
IDO-IN-2 1668565-74-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-29

1668565-74-9, IDO-IN-2Related Search:


  • DO-IN-2
  • IDO inhibitor 2
  • Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)-
  • PCC0208009
  • PCC0208009,IDO,PCC-0208009,Inhibitor,Indoleamine 2,3-Dioxygenase (IDO),PCC 0208009,inhibit,neuropathic
  • 1-(4-(diisobutylamino)-2'-(1H-tetrazol-5-yl)biphenyl-3-yl)-3-p-tolylurea
  • 1-(4-(Diisobutylamino)-2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)urea
  • PCC0208009, 10 mM in DMSO
  • 1668565-74-9
  • C29H35N7O