Avatrombopag maleate

ChemicalBook > CAS DataBase List > Avatrombopag maleate

Product Name: Avatrombopag maleate
CAS No.: 677007-74-8
Chemical Name: Avatrombopag maleate
Synonyms: 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid;Avatrombopag Meleate;677007-74-8 (MALEATE) 570406-98-3 (FREE BASE);Avatrombopag maleate，677007-74-8(MALEATE)570406-98-3(FREEBASE);4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, (2Z)-2-butenedioate (1:1);Avatrombopag Maleate;Avatrombopag Dimaleate;Avatrombopag maleate（93%）;Avatrombopag MaleateQ: What is Avatrombopag Maleate Q: What is the CAS Number of Avatrombopag Maleate;1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid maleate
CBNumber: CB43159868
Molecular Formula: C33H38Cl2N6O7S2
Formula Weight: 765.72
MOL File: 677007-74-8.mol

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Avatrombopag maleate Property

InChIKey: MISPBGHDNZYFNM-BTJKTKAUSA-N
SMILES: C(/C(=O)O)=C/C(=O)O.N(C1SC(N2CCN(C3CCCCC3)CC2)=C(C2SC=C(Cl)C=2)N=1)C(C1=CN=C(N2CCC(C(=O)O)CC2)C(Cl)=C1)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Chemenu

Product number: CM328489
Product name: (Z)-but-2-enedioicacid;1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylicacid
Purity: 95%+
Packaging: 1000g
Price: $55200
Updated: 2021/12/16

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Avatrombopag maleate Chemical Properties,Usage,Production

Description

Avatrombopag maleate is a thrombopoietin receptor (TPO) agonist developed by AkaRx Inc and approved by the US FDA in May 2018 as Doptelet (20mg). For the treatment of low platelet count (thrombocytopenia CIT) in adult patients with chronic liver disease (CLD) who are scheduled to undergo medical or dental surgery.

Chemical Properties

Avatrombopag maleate drug substance is a white to off-white, non-hygroscopic, powder that is practically insoluble in water and in 0.1 M HCl. The aqueous solubility of avatrombopag maleate at various pH levels indicates that the drug substance is practically insoluble at pH 1 to 11. Avatrombopag maleate drug substance is an achiral molecule.

Uses

Avatrombopag Maleate is the maleate salt form of avatrombopag, an orally available platelet thrombopoietin receptor (TPOR; MPL) agonist, with potential megakaryopoiesis stimulating activity.

Definition

Avatrombopag maleate is an active ingredient in Doptelet. Doptelet is provided as an immediate-release tablet. Each DOPTELET tablet contains 20 mg avatrombopag (equivalent to 23.6 mg avatrombopag maleate). Other components of Doptelet include lactose monohydrate, colloidal silicon dioxide, crospovidone, and so on.

Mechanism of action

Upon administration, Avatrombopag maleate binds to and stimulates TPOR, which may lead to the proliferation and differentiation of megakaryocytes from bone marrow progenitor cells. This increases the production of platelets and may prevent chemotherapy-induced thrombocytopenia (CIT). TPOR is a cytokine receptor and member of the hematopoietin receptor superfamily.

Synthesis

The synthesis of Avatrombopag maleate is as follows:
A mixture containing 80.1 g of 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexyl piperazin-1-yl) thiazol-2-yl] carbamoyl} pyridin-2-yl) piperidine-4-carboxylic acid, 580 mL of DMSO, 580 mL of acetone, 17.2 g of maleic acid, and 290 mL of water was stirred at 69 °C. The insoluble matter was filtered out, washed with a mixture of 32 mL of DMSO, 32 mL of acetone, and 16 mL of water, and then the filtrate was cooled and the precipitate was collected by filtering. Washing was successively performed using 150 mL of water, 80 mL of acetone, 650 mL of water, and 80 mL of acetone, followed by drying, to obtain 70.66 g of Avatrombopag maleate.

Avatrombopag maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Avatrombopag maleate manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: Avatrombopag maleate 677007-74-8
Price: US $1.00-0.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2023-12-11

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: Avatrombopag Maleate 677007-74-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞99% by HPLC
Supply Ability: 20kg/Month
Release date: 2023-01-06

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Avatrombopag Maleate 677007-74-8
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 50kg/Month
Release date: 2024-06-28

677007-74-8, Avatrombopag maleateRelated Search:

BIS(TRIMETHYLSILYL) MALONATE Unii-4U07F515lg Eltrombopag Ibopamine Hydrochloride Lusutrombopag Lusutrombopag methyl 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate Avatrombopag 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

677007-74-8 (MALEATE) 570406-98-3 (FREE BASE)

Avatrombopag Meleate

1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid

Avatrombopag Maleate

Avatrombopag maleate，677007-74-8(MALEATE)570406-98-3(FREEBASE)

Avatrombopag MaleateQ: What is Avatrombopag Maleate Q: What is the CAS Number of Avatrombopag Maleate

4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, (2Z)-2-butenedioate (1:1)

Avatrombopag Dimaleate

Avatrombopag maleate（93%）

(Z)-but-2-enedioic acid,1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid

1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid maleate

677007-74-8

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677007-74-8