4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

Product Name: 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
CAS No.: 570407-42-0
Chemical Name: 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
Synonyms: Avatrapa impurity 10;Avatrombopag Impurity 47;Avatrombopag Impurity 13;Avatroposide impurities5;Avatroposide impurities19;2-Thiazolamine, 4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-;5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine4-(4-chlorothiophen-2-yl)-;4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine;4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-y1)thiazol-2-amine;4-(4-Chloro-thiophen-2-yl)-5-(4-cyclohexyl-piperazin-1-yl)-thiazol-2-ylamine
CBNumber: CB04800390
Molecular Formula: C17H23ClN4S2
Formula Weight: 382.97
MOL File: 570407-42-0.mol

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4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Property

Boiling point:: 560.0±50.0 °C(Predicted)
Density: 1.345±0.06 g/cm3(Predicted)
pka: 7.58±0.70(Predicted)
InChI: InChI=1S/C17H23ClN4S2/c18-12-10-14(23-11-12)15-16(24-17(19)20-15)22-8-6-21(7-9-22)13-4-2-1-3-5-13/h10-11,13H,1-9H2,(H2,19,20)
InChIKey: FQQOPZRSAIEOGH-UHFFFAOYSA-N
SMILES: S1C(N2CCN(C3CCCCC3)CC2)=C(C2SC=C(Cl)C=2)N=C1N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Chemical Properties,Usage,Production

Uses

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is a valuable organic compound that could be used as an intermediate to synthesize thrombopoietin

Synthesis

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is synthesize from the reacton of 4- (4-Chloro-2-thienyl) -5-bromo-2-thiazolylamine with cyclohexylpiperazine. The reaction mixture was extracted with water and EtOAc. The combined organic phases were washed with distilled water and brine and dried to afford 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine.

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Suppliers

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Jinan XinKe Pharmaceutical Technology Co., Ltd.

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View Lastest Price from 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine 570407-42-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine 570407-42-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% by HPLC
Supply Ability: 20kg/month
Release date: 2023-01-05

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Avatrombopag Impurity 7 570407-42-0
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-02

570407-42-0, 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amineRelated Search:

Unii-4U07F515lg Eltrombopag Ibopamine Hydrochloride Lusutrombopag Avatrombopag Avatrombopag maleate 4-(4-Chloro-2-thienyl)-2-thiazolamine 5-bromo-4-(4-chlorothiophen-2-yl)thiazol-2-amine 1-Cyclohexylpiperazine

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

2-Thiazolamine, 4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-

Avatrombopag Impurity 13

5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine4-(4-chlorothiophen-2-yl)-

Avatrombopag Impurity 47

Avatroposide impurities19

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-y1)thiazol-2-amine

4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine (Avatrombopag Impurity)

Avatroposide impurities5

Avatrapa impurity 10

4-(4-Chloro-thiophen-2-yl)-5-(4-cyclohexyl-piperazin-1-yl)-thiazol-2-ylamine

570407-42-0

C17H23ClN4S2

Intermediate