Fezolinetant

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Product Name: Fezolinetant
CAS No.: 1629229-37-3
Chemical Name: Fezolinetant
Synonyms: ESN-364;Fezolinetant;Fexolinetant;FEZOLINETANT; ESN-364; ESN 364; ESN364;(S)-1-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2,3-dihydro-1H-indene-4-carbonitrile;Inhibitor,Neurokinin Receptor,ESN364,Tachykinin receptor,ESN 364,Fezolinetant,inhibit,NK receptor;(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone;Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)-
CBNumber: CB43159873
Molecular Formula: C16H15FN6OS
Formula Weight: 358.39
MOL File: 1629229-37-3.mol

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Fezolinetant Property

Boiling point:: 623.0±65.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:20.0(Max Conc. mg/mL);55.8(Max Conc. mM)
pka: -0.28±0.40(Predicted)
form: Solid
color: White to yellow
InChI: InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1
InChIKey: PPSNFPASKFYPMN-SECBINFHSA-N
SMILES: C(N1CCN2C(C3SN=C(C)N=3)=NN=C2[C@H]1C)(C1=CC=C(F)C=C1)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7952
Product name: Fezolinetant
Purity: 98.16%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-7952
Product name: Fezolinetant
Purity: 98.16%
Packaging: 5mg
Price: $390
Updated: 2021/12/16

ChemScene

Product number: CS-7952
Product name: Fezolinetant
Purity: 98.16%
Packaging: 10mg
Price: $570
Updated: 2021/12/16

ChemScene

Product number: CS-7952
Product name: Fezolinetant
Purity: 98.16%
Packaging: 25mg
Price: $1140
Updated: 2021/12/16

ChemScene

Product number: CS-7952
Product name: Fezolinetant
Purity: 98.16%
Packaging: 50mg
Price: $1740
Updated: 2021/12/16

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Fezolinetant Chemical Properties,Usage,Production

Uses

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

Definition

ChEBI: Fezolinetant is a triazolopyrazine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine substituted by 3-methyl-1,2,4-thiadiazol-5-yl, 4-fluorobenzoyl and methyl groups at positions 3, 7, and 8R, respectively. It is a prescription medicine used to reduce moderate to severe vasomotor symptoms due to menopause. It has a role as a neurokinin-3 receptor antagonist. It is a member of monofluorobenzenes, a triazolopyrazine, a member of thiadiazoles, a member of benzamides and a tertiary carboxamide.

Mechanism of action

Fezolinetant is an oral non-hormonal therapy that is an NK3R antagonist. It works by binding to and blocking the activity of NK3 receptors, which play a role in the regulation of body temperature in the brain.

Side effects

The common side effects of Fezolinetant include abdominal pain, diarrhoea, insomnia, back pain, hot flushes and elevated liver transaminases.

Fezolinetant Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fezolinetant manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: Birinapant 1629229-37-3
Price: US $1.00-0.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200
Release date: 2024-03-21

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Fezolinetant 1629229-37-3
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 50kg/Month
Release date: 2024-07-03

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Fexolinetant 1629229-37-3
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-25

1629229-37-3, FezolinetantRelated Search:

FEZOLINETANT; ESN-364; ESN 364; ESN364

ESN-364

Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)-

Inhibitor,Neurokinin Receptor,ESN364,Tachykinin receptor,ESN 364,Fezolinetant,inhibit,NK receptor

(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

Fexolinetant

Fezolinetant

(S)-1-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2,3-dihydro-1H-indene-4-carbonitrile

1629229-37-3

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