FIN56

ChemicalBook > CAS DataBase List > FIN56

Product Name: FIN56
CAS No.: 1083162-61-1
Chemical Name: FIN56
Synonyms: FIN56;FIN-56;FIN 56;FIN56 >=98% (HPLC);FIN56;FIN-56 ;FIN 56;N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide;9H-Fluorene-2,7-disulfonamide, N2,N7-dicyclohexyl-9-(hydroxyimino)-;FIN56 N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide;inhibit,GPX4,FIN56,Ferroptosis,degradation,FIN 56,Inhibitor,squalene,synthase,FIN-56
CBNumber: CB43160424
Molecular Formula: C25H31N3O5S2
Formula Weight: 517.66
MOL File: 1083162-61-1.mol

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FIN56 Property

Boiling point:: 759.1±70.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: Soluble in DMSO (>25 mg/ml)
form: powder
pka: 10.10±0.20(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1740
Product name: FIN56
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $107
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1740
Product name: FIN56
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $434
Updated: 2023/06/20

Cayman Chemical

Product number: 25180
Product name: FIN56
Purity: ≥98%
Packaging: 5mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 25180
Product name: FIN56
Purity: ≥98%
Packaging: 10mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 25180
Product name: FIN56
Purity: ≥98%
Packaging: 25mg
Price: $249
Updated: 2024/03/01

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FIN56 Chemical Properties,Usage,Production

Description

FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1? FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2

Definition

ChEBI: FIN56 is a fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase. It has a role as a ferroptosis inducer and an EC 1.11.1.9 (glutathione peroxidase) inhibitor. It is a member of fluorenes, a ketoxime and a sulfonamide. It is functionally related to a 9-hydroxyiminofluorene-2,7-disulfonamide.

Biochem/physiol Actions

Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.

storage

Store at +4°C

References

Shimada et al. (2016), Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis; Chem. Biol. 12 497 Zhang et al. (2021), FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma; Cancer 12 6610

FIN56 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FIN56 manufacturers

Career Henan Chemical Co

Product: FIN56 1083162-61-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

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N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

9H-Fluorene-2,7-disulfonamide, N2,N7-dicyclohexyl-9-(hydroxyimino)-

FIN56 >=98% (HPLC)

FIN56 N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

inhibit,GPX4,FIN56,Ferroptosis,degradation,FIN 56,Inhibitor,squalene,synthase,FIN-56

1083162-61-1