1-(2,4,5-Trihydroxyphenyl)ethanone
- Product Name
- 1-(2,4,5-Trihydroxyphenyl)ethanone
- CAS No.
- 1818-27-5
- Chemical Name
- 1-(2,4,5-Trihydroxyphenyl)ethanone
- Synonyms
- acetophenone, 2,4,5-trihydroxy;1-(2,4,5-Trihydroxyphenyl)ethanone;Ethanone, 1-(2,4,5-trihydroxyphenyl)-;1-(2,4,5-trihydroxyphenyl)ethan-1-one
- CBNumber
- CB43161931
- Molecular Formula
- C8H8O4
- Formula Weight
- 168.15
- MOL File
- 1818-27-5.mol
1-(2,4,5-Trihydroxyphenyl)ethanone Property
- Melting point:
- 200-202 °C
- Boiling point:
- 404.3±30.0 °C(Predicted)
- Density
- 1.446±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 7.81±0.23(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0060848
- Product name
- 1-(2,4,5-Trihydroxyphenyl)ethanone
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- CHM1012846
- Product name
- 1-(2,4,5-TRIHYDROXY-PHENYL)-ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.06
- Updated
- 2021/12/16
- Product number
- 9379AH
- Product name
- 1-(2,4,5-Trihydroxy-phenyl)-ethanone
- Packaging
- 5g
- Price
- $863
- Updated
- 2021/12/16
- Product number
- CS-0060848
- Product name
- 1-(2,4,5-Trihydroxyphenyl)ethanone
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A171011
- Product name
- 1-(2,4,5-Trihydroxyphenyl)ethanone
- Purity
- 97%
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
1-(2,4,5-Trihydroxyphenyl)ethanone Chemical Properties,Usage,Production
Preparation
Preparation by Fries rearrangement of 1,2,4-triacetoxy-benzene,
with aluminium chloride in nitrobenzene (30–43%)
with zinc chloride at 135–140° (49–53%)
with p-toluenesulfonic acid in refluxing tetrachloroethane or benzene or without solvent at 135–140° (60%).
Synthesis
66003-50-7
1818-27-5
General procedure for the synthesis of 1-(2,4,5-trihydroxyphenyl)ethan-1-one from 1-(6-hydroxybenzo[D][1,3]dioxolan-5-yl)ethan-1-one: The compound 1-(6-hydroxybenzo[D][1,3]dioxolan-5-yl)ethan-1-one (4 g, 19.03 mmol) was dissolved in chlorobenzene (20 mL) at room temperature, and in a Trichlorosilane (6.6 g, 49.47 mmol) was slowly added dropwise under nitrogen protection. The reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, the chlorobenzene was removed by rotary evaporation. The residue was dissolved in 1 M hydrochloric acid (50 mL) and extracted with ethyl acetate. The extract was post-treated and purified by silica gel column chromatography to afford 1-(2,4,5-trihydroxyphenyl)ethanone (2.1 g, 12.7 mmol) as a pale yellow solid in 66.9% yield.
References
[1] Patent: CN107935982, 2018, A. Location in patent: Paragraph 0023; 0024
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 13, p. 3872 - 3875
1-(2,4,5-Trihydroxyphenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2,4,5-Trihydroxyphenyl)ethanone manufacturers
- Product
- 1-(2,4,5-Trihydroxyphenyl)ethanone 1818-27-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09