4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine
- Product Name
- 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine
- CAS No.
- 1770840-43-1
- Chemical Name
- 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine
- Synonyms
- SKL530;Remdesivir-004;Starting material);4-Amino-7-iodopyrroL;Redesivir Impurity 3;Remdesivir Impurity 20;o[2,1-f][1,2,4]triazine;Remdesivir N-6 iodotriazine;7-iodopyrrolo[2,1-f][1,2,4]triazin-4-;7-iodopyrrole[2,1-f][1,2,4]triazin-4-amine
- CBNumber
- CB43166572
- Molecular Formula
- C6H5IN4
- Formula Weight
- 260.04
- MOL File
- 1770840-43-1.mol
4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine Property
- Density
- 2.43±0.1 g/cm3(Predicted)
- pka
- 3.04±0.30(Predicted)
- form
- solid
- color
- Pale yellow
- InChI
- InChI=1S/C6H5IN4/c7-5-2-1-4-6(8)9-3-10-11(4)5/h1-3H,(H2,8,9,10)
- InChIKey
- ZEBGLCLVPCOXIV-UHFFFAOYSA-N
- SMILES
- N12C(I)=CC=C1C(N)=NC=N2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I1139
- Product name
- 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine
- Packaging
- 1G
- Price
- $87
- Updated
- 2025/07/31
- Product number
- I1139
- Product name
- 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine
- Packaging
- 5G
- Price
- $263
- Updated
- 2025/07/31
- Product number
- 3155EB
- Product name
- 4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 250mg
- Price
- $323
- Updated
- 2021/12/16
- Product number
- 3H30-H-0K
- Product name
- 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine
- Purity
- 97%
- Packaging
- 25g
- Price
- $336
- Updated
- 2021/12/16
- Product number
- 3155EB
- Product name
- 4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine
- Packaging
- 1g
- Price
- $458
- Updated
- 2021/12/16
4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine Chemical Properties,Usage,Production
Uses
4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an amine organic substance and can be used as an intermediate for APIs.
Uses
7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine is a useful reagent in the synthesis of phosphoramidate GS-5734 prodrug for potential treatment of Ebola virus infections and in the preparation of Remdesivir as COVID-19 antiviral drug candidate.
Synthesis
The synthesis reaction of 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine is as follows:
4-amino pyrrolo [2,1-f ] [1,2,4] triazine reacts with iodine or iodine chloride under mild conditions to generate most of iodinated products, isomers and diiodized products are not generated under the mild conditions, and unreacted materials react with N-iodosuccinimide to further ensure that raw materials completely react, so that the conversion rate of the raw materials is improved, and the generation of the isomer products and the diiodized products is also inhibited.
4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine manufacturers
- Product
- 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine 1770840-43-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kgs
- Release date
- 2025-09-25
- Product
- 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine 1770840-43-1
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20mt
- Release date
- 2020-03-31
- Product
- 4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine 1770840-43-1
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24