BPO-27 (racemate)

Product Name: BPO-27 (racemate)
CAS No.: 1314873-02-3
Chemical Name: BPO-27 (racemate)
Synonyms: BPO-27 racemat;BPO-27 (racemate);BPO-27 racemate, 10 mM in DMSO;BPO 27 RACEMATE; BPO27 RACEMATE;Inhibitor,Cystic fibrosis transmembrane conductance regulator,inhibit,BPO27 racemate,Autophagy,BPO-27,BPO 27,BPO 27 racemate,BPO27,CFTR;6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-;6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-benzo[b]pyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazine-2-carboxylic acid
CBNumber: CB43167599
Molecular Formula: C26H18BrN3O6
Formula Weight: 548.34
MOL File: 1314873-02-3.mol

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BPO-27 (racemate) Property

Boiling point:: 732.9±70.0 °C(Predicted)
Density: 1.68±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6 mg/mL (10.94 mM)
form: Solid
pka: 3.76±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6271
Product name: BPO-27racemate
Purity: 98.37%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-6271
Product name: BPO-27racemate
Purity: 98.37%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6271
Product name: BPO-27racemate
Purity: 98.37%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-6271
Product name: BPO-27racemate
Purity: 98.37%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-6271
Product name: BPO-27racemate
Purity: 98.37%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

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BPO-27 (racemate) Chemical Properties,Usage,Production

Uses

BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.

in vivo

Following bolus interperitoneal administration in mice, serum (R)-1 decays with t_1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in kidney^[1].

References

[1] Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459. DOI:10.1021/ml400069k
[2] Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. DOI:10.1124/mol.115.098368

BPO-27 (racemate) Preparation Products And Raw materials

Raw materials

Preparation Products

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BPO-27 (racemate) Suppliers

China 24 United States 4 USA 1 Global 29

MedChemexpress LLC

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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TargetMol Chemicals Inc.

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Suzhou Zhixin Biotechnology Co., Ltd.

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Taizhou GreenChem Pharma-Tech Co.,Ltd

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1314873-02-3, BPO-27 (racemate)Related Search:

BPO-27 (racemate)

BPO 27 RACEMATE; BPO27 RACEMATE

BPO-27 racemat

6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-

Inhibitor,Cystic fibrosis transmembrane conductance regulator,inhibit,BPO27 racemate,Autophagy,BPO-27,BPO 27,BPO 27 racemate,BPO27,CFTR

6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-benzo[b]pyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazine-2-carboxylic acid

BPO-27 racemate, 10 mM in DMSO

1314873-02-3

C26H18BrN3O6