ChemicalBook > CAS DataBase List > BPO-27 (racemate)
BPO-27 (racemate)
- Product Name
- BPO-27 (racemate)
- CAS No.
- 1314873-02-3
- Chemical Name
- BPO-27 (racemate)
- Synonyms
- BPO-27 racemat;BPO-27 (racemate);BPO-27 racemate, 10 mM in DMSO;BPO 27 RACEMATE; BPO27 RACEMATE;Inhibitor,Cystic fibrosis transmembrane conductance regulator,inhibit,BPO27 racemate,Autophagy,BPO-27,BPO 27,BPO 27 racemate,BPO27,CFTR;6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-;6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-benzo[b]pyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazine-2-carboxylic acid
- CBNumber
- CB43167599
- Molecular Formula
- C26H18BrN3O6
- Formula Weight
- 548.34
- MOL File
- 1314873-02-3.mol
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BPO-27 (racemate) Property
- Boiling point:
- 732.9±70.0 °C(Predicted)
- Density
- 1.68±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 6 mg/mL (10.94 mM)
- form
- Solid
- pka
- 3.76±0.40(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-6271
- Product name
- BPO-27racemate
- Purity
- 98.37%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6271
- Product name
- BPO-27racemate
- Purity
- 98.37%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6271
- Product name
- BPO-27racemate
- Purity
- 98.37%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6271
- Product name
- BPO-27racemate
- Purity
- 98.37%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6271
- Product name
- BPO-27racemate
- Purity
- 98.37%
- Packaging
- 100mg
- Price
- $2520
- Updated
- 2021/12/16
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BPO-27 (racemate) Chemical Properties,Usage,Production
Uses
BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.
in vivo
Following bolus interperitoneal administration in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in kidney[1].
References
[1] Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459. DOI:10.1021/ml400069k
[2] Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. DOI:10.1124/mol.115.098368
BPO-27 (racemate) Preparation Products And Raw materials
Raw materials
Preparation Products
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BPO-27 (racemate) Suppliers
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