COENZYME A TRILITHIUM SALT Property

Melting point:

>203°C (dec.)

storage temp. 

-20°C

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Sonicated), Water (Slightly)

form 

Off-white solid

color 

White to Off-White

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

Stability:

Hygroscopic

InChIKey

QSCBPHBAFBVXRK-HJKJOZROSA-K

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

F 

3-10-23

HS Code 

29349990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COENZYME A TRILITHIUM SALT Chemical Properties,Usage,Production

Chemical Properties

Beige crystals

Uses

A cofactor in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofol ate dehydrogenase

Uses

Coenzyme A trilithium salt has been used:

• in standard curve generation in the kinetic assay of acetyltransferase Gcn5 acylation
• as a cofactor in JNADH and JNADPH production assay
• in the labeling of Alexa647 (AF647) probe

General Description

Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.

Biochem/physiol Actions

Coenzyme A is a ubiquitous cofactor, synthesized from pantothenic acid through a ATP dependent reaction. It plays a vital role in tricarboxylic acid cycle, metabolism of short- and long-chain fatty acids. In addition, it also aids in synthesis of phospholipids and cell growth.