ChemicalBook > CAS DataBase List > Coenzyme A

Coenzyme A

Product Name
Coenzyme A
CAS No.
85-61-0
Chemical Name
Coenzyme A
Synonyms
COA;COA-SH;COENZYME A HYDRATE;Coalip;Lucina;Aluzime;Thiol-CoA;SHUIRUJIE;COENZYME A;CONENZYME A
CBNumber
CB8854470
Molecular Formula
C21H36N7O16P3S
Formula Weight
767.53
MOL File
85-61-0.mol
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Coenzyme A Property

Density 
1.96±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
pka
9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
color 
White to light yellow
Merck 
13,2491
BRN 
77809
InChI
InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1
InChIKey
RGJOEKWQDUBAIZ-IBOSZNHHSA-N
SMILES
SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O
LogP
-4.358 (est)
EPA Substance Registry System
Coenzyme A (85-61-0)
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Safety

Safety Statements 
24/25
WGK Germany 
3
1-10
TSCA 
Yes
HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C4282
Product name
Coenzyme A hydrate
Purity
≥85% (UV, HPLC)
Packaging
10mg
Price
$81.3
Updated
2024/03/01
Sigma-Aldrich
Product number
C4282
Product name
Coenzyme A hydrate
Purity
≥85% (UV, HPLC)
Packaging
25mg
Price
$135
Updated
2024/03/01
Alfa Aesar
Product number
J13787
Product name
Coenzyme A trihydrate, free acid, Affymetrix/USB
Packaging
50mg
Price
$108.19
Updated
2021/12/16
Alfa Aesar
Product number
J13787
Product name
Coenzyme A trihydrate, free acid, Affymetrix/USB
Packaging
1g
Price
$1350.25
Updated
2021/12/16
Cayman Chemical
Product number
16147
Product name
Coenzyme A
Purity
≥98%
Packaging
10mg
Price
$74
Updated
2024/03/01
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Coenzyme A Chemical Properties,Usage,Production

Description

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Chemical Properties

yellowish lyophilisate

Uses

A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.

Uses

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Definition

ChEBI: Coenzyme A is a thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. It has a role as an Escherichia coli metabolite, a mouse metabolite and a coenzyme. It is functionally related to an ADP. It is a conjugate acid of a coenzyme A(4-).

General Description

Coenzyme A (CoA) is a cofactor with a molecular weight of 797 Da. Its biological structure is formed from pantothenic acid (vitamin B5), cysteine and adenosine triphosphate through an evolutionarily conserved pathway. CoA is primarily involved in cellular oxidative pathways, including fatty acid beta-oxidation, carbohydrate, amino acid oxidation, and the Krebs cycle; as well as in lipid synthesis, protein modification, and membrane transport. CoA serves as a carrier for the activation of acyl groups, which can be transferred to amides, esters, or acid anhydrides. CoA can also be regulate a variety of metabolic processes at different levels as substrates, allosteric regulators, and through post-translational modifications of histones and other non-histone proteins. It is an essential cofactor in all organisms.

Biochem/physiol Actions

Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes.

Purification Methods

The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]

Coenzyme A Preparation Products And Raw materials

Raw materials

Preparation Products

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Coenzyme A Suppliers

Hubei XinghengKang Chemical Technology Co., Ltd.
Tel
027-88878869 18162384755
Fax
027-88878869
Email
xhkhu2014@163.com
Country
China
ProdList
239
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58
Hubei Lingyan Biotechnology Co., Ltd
Tel
027-59304846 13297025796
Email
2331003879@qq.com
Country
China
ProdList
60
Advantage
58
Suizhou HongQi Chemical Corporation Limited
Tel
0722-3257376 13026100080
Fax
0722-3257381
Email
774811011@qq.com
Country
China
ProdList
64
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55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Hubei deante Chemical Technology Co., Ltd
Tel
15927262683
Email
3244356795@qq.com
Country
China
ProdList
816
Advantage
58
Suizhou Jiake Biological Engineering Co., Ltd.
Tel
0722-3632989 18008664499
Fax
0722-3255139
Email
2286801987@qq.com
Country
China
ProdList
103
Advantage
58
Hubei Zhengxingyuan Fine Chemical Co., Ltd.
Tel
027-87879189 15207106154
Fax
027-87879189
Email
3386829764@qq.com
Country
China
ProdList
309
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58
Xinxiang Yicheng Biotechnology Co.,LTD
Tel
0373-6014999 18937330588
Email
xxycswsale@163.com
Country
China
ProdList
69
Advantage
58
OXSYNS
Tel
13521451709 13521451709
Email
xin.li@oxsyns.com
Country
China
ProdList
19
Advantage
58
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View Lastest Price from Coenzyme A manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Coenzyme A 85-61-0
Price
US $85.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-22
BINBO BIOLOGICAL CO.,LTD
Product
Coenzyme A 85-61-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
1000 kg
Release date
2024-04-05
Hebei Chuanghai Biotechnology Co,.LTD
Product
Coenzyme A 85-61-0
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20

85-61-0, Coenzyme ARelated Search:


  • [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
  • CONENZYME A
  • Coenzyme a, free acid
  • Coenzyme A, free acid, lyophilized, min. 75% (enzym.)
  • COENZYME A FREE ACID FROM YEAST
  • Coenzyme A, free acid, lyophilized, 75%
  • Coenzyme A / Q0 / Q10
  • COENZYM A FREE ACID
  • COENZYME A (COA)
  • CoenzyMe A hydrate (free acid)
  • Coenzyme A hydrate,CoA
  • [5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
  • Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester
  • Aluzime
  • Coenzyme ASH
  • D-Coenzyme A
  • Coalip
  • Lucina
  • Thiol-CoA
  • Coenzyme A,75%,free acid, lyophilized
  • Coenzyme A, free acid, hydrate (COA)
  • coenzyme A(4-)
  • SHUIRUJIE
  • COENZYME A HYDRATE
  • COENZYME A
  • COA
  • COA-SH
  • Coenzyme A, Free Acid(CoA)
  • COENZYMEA 96%, TRILITH. D1GM
  • Coenzyme A USP/EP/BP
  • (((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy((R)-3-hydroxy-2,2-dimethyl-3-((2-((2-sulfanylethyl)carbamoyl)ethyl)carbamoyl)propoxy)phosphoryl)oxy)phosphoryl)oxy)methyl)oxolan-3-yl)oxy)phosphonic acid
  • Delivery Coenzyme
  • CoASH (Coenzyme A-SH), 80%
  • [[(2S,3R,4S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
  • Coenzyme A (8CI, 9CI, ACI)
  • Acetyl Coenzyme
  • 85-61-0
  • 85-16-0
  • C21H36N7O16P3S
  • C21H36N7O16P3S3H2O
  • C21H38N7O17P3S
  • C21H32N7O16P3S
  • C21H36N7O16P3SxH2O
  • C21H36N7O16P3SH2O
  • Metabolic Libraries
  • Lipid Library
  • Nucleosides, Nucleotides, Oligonucleotides
  • Biochemicals and Reagents
  • BioChemical
  • Coenzyme A and Derivatives
  • Metabolomics
  • Vitamin series
  • 85-61-0