Coenzyme A

Product Name: Coenzyme A
CAS No.: 85-61-0
Chemical Name: Coenzyme A
Synonyms: COA;COA-SH;COENZYME A HYDRATE;Coalip;Lucina;Aluzime;Thiol-CoA;SHUIRUJIE;COENZYME A;CONENZYME A
CBNumber: CB8854470
Molecular Formula: C21H36N7O16P3S
Formula Weight: 767.53
MOL File: 85-61-0.mol

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Coenzyme A Property

Density: 1.96±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
pka: 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
color: White to light yellow
Merck: 13,2491
BRN: 77809
InChI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1
InChIKey: RGJOEKWQDUBAIZ-IBOSZNHHSA-N
SMILES: SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O
LogP: -4.358 (est)
EPA Substance Registry System: Coenzyme A (85-61-0)

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Safety

Safety Statements: 24/25
WGK Germany: 3
F: 1-10
TSCA: Yes
HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C4282
Product name: Coenzyme A hydrate
Purity: ≥85% (UV, HPLC)
Packaging: 10mg
Price: $81.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: C4282
Product name: Coenzyme A hydrate
Purity: ≥85% (UV, HPLC)
Packaging: 25mg
Price: $135
Updated: 2024/03/01

Alfa Aesar

Product number: J13787
Product name: Coenzyme A trihydrate, free acid, Affymetrix/USB
Packaging: 50mg
Price: $108.19
Updated: 2021/12/16

Alfa Aesar

Product number: J13787
Product name: Coenzyme A trihydrate, free acid, Affymetrix/USB
Packaging: 1g
Price: $1350.25
Updated: 2021/12/16

Cayman Chemical

Product number: 16147
Product name: Coenzyme A
Purity: ≥98%
Packaging: 10mg
Price: $74
Updated: 2024/03/01

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Coenzyme A Chemical Properties,Usage,Production

Description

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Chemical Properties

yellowish lyophilisate

Uses

A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.

Uses

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Definition

ChEBI: Coenzyme A is a thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. It has a role as an Escherichia coli metabolite, a mouse metabolite and a coenzyme. It is functionally related to an ADP. It is a conjugate acid of a coenzyme A(4-).

General Description

Coenzyme A (CoA) is a cofactor with a molecular weight of 797 Da. Its biological structure is formed from pantothenic acid (vitamin B5), cysteine and adenosine triphosphate through an evolutionarily conserved pathway. CoA is primarily involved in cellular oxidative pathways, including fatty acid beta-oxidation, carbohydrate, amino acid oxidation, and the Krebs cycle; as well as in lipid synthesis, protein modification, and membrane transport. CoA serves as a carrier for the activation of acyl groups, which can be transferred to amides, esters, or acid anhydrides. CoA can also be regulate a variety of metabolic processes at different levels as substrates, allosteric regulators, and through post-translational modifications of histones and other non-histone proteins. It is an essential cofactor in all organisms.

Biochem/physiol Actions

Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes.

Purification Methods

The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]

Coenzyme A Preparation Products And Raw materials

Raw materials

Adenine D-Ribose Cysteamine AMBERLITE(R) IRC-50 Adsorption resin Ion exchange resin column D-PANTOTHENIC ACID

Preparation Products

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Coenzyme A Suppliers

Belgium 1 Canada 2 China 251 China Hong Kong 1 Germany 5 India 8 Japan 1 Switzerland 1 United Kingdom 3 United States 29 Global 302

Hubei XinghengKang Chemical Technology Co., Ltd.

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Nanjing Sunlida Biological Technology Co., Ltd.

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Raw material medicin reagent co.,Ltd

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Hubei deante Chemical Technology Co., Ltd

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Hubei Zhengxingyuan Fine Chemical Co., Ltd.

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Xinxiang Yicheng Biotechnology Co.,LTD

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OXSYNS

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INTATRADE GmbH

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Country: Germany
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View Lastest Price from Coenzyme A manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Coenzyme A 85-61-0
Price: US $85.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-22

BINBO BIOLOGICAL CO.,LTD

Product: Coenzyme A 85-61-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-05

Hebei Chuanghai Biotechnology Co,.LTD

Product: Coenzyme A 85-61-0
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-20

85-61-0, Coenzyme ARelated Search:

Coenzyme Q10 SUCCINYL COENZYME A SODIUM SALT COENZYME COENZYME A TRILITHIUM SALT ACETYL COENZYME A (C2:0) LITHIUM Acetyl coenzyme A sodium salt Cocarboxylase D-Biotin NADH, disodium salt NAD+ COENZYME Q9 LAUROYL COENZYME A C12:0 LITHIUM SALT,N-DODECANOYL COENZYME A LITHIUM SALT NADP, Disodium Salt Nadph tetrasodium salt MALONYL COENZYME A TETRALITHIUM SALT 2,3-Dimethoxy-5-methyl-p-benzoquinone COENZYME A SODIUM SALT N-DECANOYL COENZYME A (C10:0)

[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid

CONENZYME A

Coenzyme a, free acid

Coenzyme A, free acid, lyophilized, min. 75% (enzym.)

COENZYME A FREE ACID FROM YEAST

Coenzyme A, free acid, lyophilized, 75%

Coenzyme A / Q0 / Q10

COENZYM A FREE ACID

COENZYME A (COA)

CoenzyMe A hydrate (free acid)

Coenzyme A hydrate,CoA

[5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid

Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester

Aluzime

Coenzyme ASH

D-Coenzyme A

Coalip

Lucina

Thiol-CoA

Coenzyme A,75%,free acid, lyophilized

Coenzyme A, free acid, hydrate (COA)

coenzyme A(4-)

SHUIRUJIE

COENZYME A HYDRATE

COENZYME A

COA

COA-SH

Coenzyme A, Free Acid(CoA)

COENZYMEA 96%, TRILITH. D1GM

Coenzyme A USP/EP/BP

(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy((R)-3-hydroxy-2,2-dimethyl-3-((2-((2-sulfanylethyl)carbamoyl)ethyl)carbamoyl)propoxy)phosphoryl)oxy)phosphoryl)oxy)methyl)oxolan-3-yl)oxy)phosphonic acid

Delivery Coenzyme

CoASH (Coenzyme A-SH), 80%

[[(2S,3R,4S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate

Coenzyme A (8CI, 9CI, ACI)

Acetyl Coenzyme

85-61-0

85-16-0

C21H36N7O16P3S

C21H36N7O16P3S3H2O

C21H38N7O17P3S

C21H32N7O16P3S

C21H36N7O16P3SxH2O

C21H36N7O16P3SH2O

Metabolic Libraries

Lipid Library

Nucleosides, Nucleotides, Oligonucleotides

Biochemicals and Reagents

BioChemical

Coenzyme A and Derivatives

Metabolomics

Vitamin series

85-61-0