Cysteamine
- Product Name
- Cysteamine
- CAS No.
- 60-23-1
- Chemical Name
- Cysteamine
- Synonyms
- CYSTEAMINE;mercaptamine;2-MERCAPTOETHYLAMINE;Cysteamin;Cysteamide;Cisteamina;2-amino-ethanethio;2-Amino-1-ethanethiol;β-MEA;L-1573
- CBNumber
- CB2223766
- Molecular Formula
- C2H7NS
- Formula Weight
- 77.15
- MOL File
- 60-23-1.mol
Cysteamine Property
- Melting point:
- 95°C
- Boiling point:
- 130 °C
- Density
- 0.934 (estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- 2-8°C
- Water Solubility
- Soluble in water
- form
- Powder
- pka
- 8.35(at 25℃)
- color
- White to slightly yellow
- Merck
- 14,2779
- BRN
- 635649
- Stability:
- Stable, but may be air-sensitive. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 60-23-1(CAS DataBase Reference)
- EPA Substance Registry System
- Cysteamine (60-23-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- RIDADR
- 3259
- WGK Germany
- 3
- RTECS
- KJ0175000
- F
- 1-3-10-13-34
- HS Code
- 29309090
- Hazardous Substances Data
- 60-23-1(Hazardous Substances Data)
- Toxicity
- LD50 in mice (mg/kg): 625 orally; 250 i.p. (Klayman); (Srivastava, Field)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 30070
- Product name
- Cysteamine
- Purity
- ≥98.0% (RT)
- Packaging
- 10g
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 30070
- Product name
- Cysteamine
- Purity
- ≥98.0% (RT)
- Packaging
- 50g
- Price
- $770
- Updated
- 2024/03/01
- Product number
- 641022
- Product name
- 2-Mercaptoethylamine, polymer-bound
- Purity
- 70-90?mesh, extent of labeling: 0.6-1.1?mmol/g loading, 1?% cross-linked with divinylbenzene
- Packaging
- 5G
- Price
- $295
- Updated
- 2023/06/20
- Product number
- 641022
- Product name
- 2-Mercaptoethylamine, polymer-bound
- Purity
- 70-90?mesh, extent of labeling: 0.6-1.1?mmol/g loading, 1?% cross-linked with divinylbenzene
- Packaging
- 25G
- Price
- $1100
- Updated
- 2023/06/20
- Product number
- A0648
- Product name
- 2-Aminoethanethiol
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $55
- Updated
- 2024/03/01
Cysteamine Chemical Properties,Usage,Production
Description
2-AMINOETHANETHIOL is the chemical compound with the formula HSCH2CH2NH2. It is the simplest stable aminothiol and a degradation product of the amino acid cysteine. It is often used as the hydrochloride salt, HSCH2CH2NH3Cl. The comparatively high melting point of cysteamine (95-97 °C), indicates that exists in a salt form.
Chemical Properties
2-AMINOETHANETHIOL is white powder
Uses
antihyperlipidemic, HMGCoA reductase inhibitor
Uses
Scavenges benzyl and allyl halides and ketones.
Uses
Cysteamine is suitable for use:
- in the preparation of cysteamine modified gold nanoparticles (AuNP)
- in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond
- to enhance in vitro development of porcine oocytes matured and fertilized in vitro
- in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange
- as a radioprotector
- to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content
- as a scavenger in electrophoretic gels (acetic acid/urea gels)
Uses
2-Aminoethanethiol is used in preparation method of fluorescence quenching array sensor based on cadmium telluride quantum dots and application in qualitative discrimination and quantitative analysis of organic acids.
Preparation
Cysteamine can also be prepared by the reaction of ethylenimine with hydrogen sulfide.
(NHCH2CH2) + H2S → HSCH2CH2NH2.
Definition
2-AMINOETHANETHIOL is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.
Reactions
2-AMINOETHANETHIOL is used as the hydrochloride salt, as it readily oxidizes to the corresponding disulfide, in the presence of air. The amine portion of the molecule serves as a catalyst for this reaction.
4 HSCH2CH2NH2 + O2 → 2 NH2CH2CH2SSCH2CH2NH2 + 2 H2O.
Pharmaceutical Applications
Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria.
It is also used for treatment of radiation sickness.
Cysteamine is used in the body to form the essential biochemical coenzyme A by combining with pantothenate and adenosine triphosphate.
In 2008, Raptor Pharmaceuticals started phase II clinical trials testing a delayed release (DR) preparation of cysteamine bitartrate for Huntington's disease. DR Cysteamine is also being investigated as a treatment for cystinosis, Batten disease, and non-alcoholic steatohepatitis.
Biochem/physiol Actions
Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis.
Safety Profile
Poison by intravenous, subcutaneous, and intraperitoneal routesModerately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NOx,.
Purification Methods
It is soluble in H2O giving an alkaline reaction, and it has a disagreeable odour. A likely impurity is the disulfide cystamine which is not soluble in alkaline solution. Under a N2 atmosphere dissolve it in EtOH, evaporate to dryness and wash the white residue with dry pet ether, then sublime it at 0.1mm and store it under N2 at 0-10o in the dark. Its HgCl2 (2:3) complex has m 181-182o (from H2O), and its picrate has m 125-126o. [Mills & Bogert J Am Chem Soc 57 2328 1935, 62 1173 1940, Baddiley & Thain J Chem Soc 800 1952, Shirley Preparation of Organic Intermediates (J. Wiley) Vol 3 189 1951, Barkowski & Hedberg J Am Chem Soc 109 6989 1987, Beilstein 4 IV 1570.]
Cysteamine Preparation Products And Raw materials
Raw materials
Preparation Products
Cysteamine Suppliers
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View Lastest Price from Cysteamine manufacturers
- Product
- 2-AMINOETHANETHIOL 60-23-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2-Aminoethanethiol 60-23-1
- Price
- US $1500.00/Kg
- Min. Order
- 1Kg
- Purity
- 96
- Supply Ability
- 500 Kg
- Release date
- 2024-03-19
- Product
- cysteamine 60-23-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 9000kg/per week
- Release date
- 2021-06-12