Cysteamine

ChemicalBook > CAS DataBase List > Cysteamine

Product Name: Cysteamine
CAS No.: 60-23-1
Chemical Name: Cysteamine
Synonyms: CYSTEAMINE;mercaptamine;2-MERCAPTOETHYLAMINE;Cysteamin;Cysteamide;Cisteamina;2-amino-ethanethio;2-Amino-1-ethanethiol;β-MEA;L-1573
CBNumber: CB2223766
Molecular Formula: C2H7NS
Formula Weight: 77.15
MOL File: 60-23-1.mol

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Cysteamine Property

Melting point:: 95°C
Boiling point:: 130 °C
Density: 0.934 (estimate)
refractive index: 1.5300 (estimate)
storage temp.: 2-8°C
Water Solubility: Soluble in water
form: Powder
pka: 8.35(at 25℃)
color: White to slightly yellow
Merck: 14,2779
BRN: 635649
Stability:: Stable, but may be air-sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 60-23-1(CAS DataBase Reference)
EPA Substance Registry System: Cysteamine (60-23-1)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
RIDADR: 3259
WGK Germany: 3
RTECS: KJ0175000
F: 1-3-10-13-34
HS Code: 29309090
Hazardous Substances Data: 60-23-1(Hazardous Substances Data)
Toxicity: LD50 in mice (mg/kg): 625 orally; 250 i.p. (Klayman); (Srivastava, Field)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 30070
Product name: Cysteamine
Purity: ≥98.0% (RT)
Packaging: 10g
Price: $187
Updated: 2024/03/01

Sigma-Aldrich

Product number: 30070
Product name: Cysteamine
Purity: ≥98.0% (RT)
Packaging: 50g
Price: $770
Updated: 2024/03/01

Sigma-Aldrich

Product number: 641022
Product name: 2-Mercaptoethylamine, polymer-bound
Purity: 70-90?mesh, extent of labeling: 0.6-1.1?mmol/g loading, 1?% cross-linked with divinylbenzene
Packaging: 5G
Price: $295
Updated: 2023/06/20

Sigma-Aldrich

Product number: 641022
Product name: 2-Mercaptoethylamine, polymer-bound
Purity: 70-90?mesh, extent of labeling: 0.6-1.1?mmol/g loading, 1?% cross-linked with divinylbenzene
Packaging: 25G
Price: $1100
Updated: 2023/06/20

TCI Chemical

Product number: A0648
Product name: 2-Aminoethanethiol
Purity: >95.0%(T)
Packaging: 25g
Price: $55
Updated: 2024/03/01

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Cysteamine Chemical Properties,Usage,Production

Description

2-AMINOETHANETHIOL is the chemical compound with the formula HSCH₂CH₂NH₂. It is the simplest stable aminothiol and a degradation product of the amino acid cysteine. It is often used as the hydrochloride salt, HSCH₂CH₂NH₃Cl. The comparatively high melting point of cysteamine (95-97 °C), indicates that exists in a salt form.

Chemical Properties

2-AMINOETHANETHIOL is white powder

Uses

antihyperlipidemic, HMGCoA reductase inhibitor

Uses

Scavenges benzyl and allyl halides and ketones.

Uses

Cysteamine is suitable for use:

in the preparation of cysteamine modified gold nanoparticles (AuNP)
in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond
to enhance in vitro development of porcine oocytes matured and fertilized in vitro
in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange
as a radioprotector
to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content
as a scavenger in electrophoretic gels (acetic acid/urea gels)

Uses

2-Aminoethanethiol is used in preparation method of fluorescence quenching array sensor based on cadmium telluride quantum dots and application in qualitative discrimination and quantitative analysis of organic acids.

Preparation

Cysteamine can also be prepared by the reaction of ethylenimine with hydrogen sulfide.
(NHCH₂CH₂) + H₂S → HSCH₂CH₂NH₂.

Definition

2-AMINOETHANETHIOL is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.

Reactions

2-AMINOETHANETHIOL is used as the hydrochloride salt, as it readily oxidizes to the corresponding disulfide, in the presence of air. The amine portion of the molecule serves as a catalyst for this reaction.
4 HSCH₂CH₂NH₂ + O₂ → 2 NH₂CH₂CH₂SSCH₂CH₂NH₂ + 2 H₂O.

Pharmaceutical Applications

Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria.
It is also used for treatment of radiation sickness.
Cysteamine is used in the body to form the essential biochemical coenzyme A by combining with pantothenate and adenosine triphosphate.
In 2008, Raptor Pharmaceuticals started phase II clinical trials testing a delayed release (DR) preparation of cysteamine bitartrate for Huntington's disease. DR Cysteamine is also being investigated as a treatment for cystinosis, Batten disease, and non-alcoholic steatohepatitis.

Biochem/physiol Actions

Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis.

Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routesModerately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NOx,.

Purification Methods

It is soluble in H2O giving an alkaline reaction, and it has a disagreeable odour. A likely impurity is the disulfide cystamine which is not soluble in alkaline solution. Under a N2 atmosphere dissolve it in EtOH, evaporate to dryness and wash the white residue with dry pet ether, then sublime it at 0.1mm and store it under N2 at 0-10o in the dark. Its HgCl2 (2:3) complex has m 181-182o (from H2O), and its picrate has m 125-126o. [Mills & Bogert J Am Chem Soc 57 2328 1935, 62 1173 1940, Baddiley & Thain J Chem Soc 800 1952, Shirley Preparation of Organic Intermediates (J. Wiley) Vol 3 189 1951, Barkowski & Hedberg J Am Chem Soc 109 6989 1987, Beilstein 4 IV 1570.]

Cysteamine Preparation Products And Raw materials

Raw materials

Hydrogen Sulfide Ethyleneimine

Preparation Products

Thiacloprid 4-[[(2-aminoethyl)thio]methyl]-5-methylimidazole Fosthiazate Coenzyme A

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Cysteamine Suppliers

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View Lastest Price from Cysteamine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-AMINOETHANETHIOL 60-23-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

R&D Scientific Inc.

Product: 2-Aminoethanethiol 60-23-1
Price: US $1500.00/Kg
Min. Order: 1Kg
Purity: 96
Supply Ability: 500 Kg
Release date: 2024-03-19

Hebei Lingding Biotechnology Co., Ltd.

Product: cysteamine 60-23-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 9000kg/per week
Release date: 2021-06-12

60-23-1, CysteamineRelated Search:

LANTHIONINE Z-CYS(BZL)-OH N-Acetyl-L-cysteine D-PENICILLAMINE DISULFIDE CHES N-ACETYL-DL-PENICILLAMINE S-CARBOXYMETHYL-L-CYSTEINE Pseudothiohydantoin Tiopronin D-Cystine S-Methyl-L-cysteine 2-(BUTYLAMINO)ETHANETHIOL S-tert-Butylmercapto-l-cysteine Taurodeoxycholic acid sodium salt DL-Cysteine S-Trityl-L-cysteine DL-PENICILLAMINE 2-Aminoethanethiol·hydrochloric acid,2-Aminoethanethiol hydrochloride ( cysteamine hydrochloride)

2-Amino-1-ethanethiol

2-amino-ethanethio

2-Aminoethyl mercaptan

2-aminoethylmercaptan

THIOETHANOLAMINE

2-MERCAPTOETHYLAMINE

2-MERCAPTOETHYLAMINE, POLYMER-BOUND

2-AMINOETHANETHIOL

DECARBOXYCYSTEINE

CYSTEAMINE

AURORA KA-7615

Beeaptan

BETA-MERCAPTOETHYLAMINE

cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine, Mercaptamine

2-mercaptoethylammonium

2-Aminoet-hylmercaptan

2-Mercaptoethanamine

Ethanethiol, 2-aMino-(8CI,9CI)

CysteaMine ~95%

Cysteamine(β-MEA)

Aminoethyl mercaptan

Becaptan

beta-Aminoethanethiol

beta-Aminoethylthiol

beta-MEA

Cisteamina

Cysteamide

Cysteamin

Cysteinamine

Ethanethiol, 2-amino-

Ethanethiolamine

L-1573

Lambraten

Lambratene

Mecramine

Mercamin

Mercamine

Mercaptamin

mercaptamine

2-AMINOETHANETHIOL 156-57-0

-Mercaptoethylamine

Merkamin

Riacon

2-Aminoethanthiol

2-mercaptoethylamine free base

2,2,4-trimethyl-1,2-dihydroquinoline (oligomers)

C01678

Cysteamine,β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine

Cysteamine 2-Mercaptoethylamine

CYSTEAMINE HYDROCHLORIDE(P)

β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine

JACS-60-23-1

2-Aminoethanethiol &gt

Aminoethanethiol...

cysteanine

2-AMINOETHANETHIOL USP/EP/BP

β-MEA

β-Mercaptoethylamine