ChemicalBook > CAS DataBase List > Coenzyme A

Coenzyme A

Product Name
Coenzyme A
CAS No.
85-61-0
Chemical Name
Coenzyme A
Synonyms
COA;COA-SH;COENZYME A HYDRATE;Coalip;Lucina;Aluzime;Thiol-CoA;SHUIRUJIE;COENZYME A;CONENZYME A
CBNumber
CB8854470
Molecular Formula
C21H36N7O16P3S
Formula Weight
767.53
MOL File
85-61-0.mol
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Coenzyme A Property

Density 
1.96±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
pka
9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
Merck 
13,2491
BRN 
77809
LogP
-4.358 (est)
EPA Substance Registry System
Coenzyme A (85-61-0)
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
1-10
TSCA 
Yes
HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C4282
Product name
Coenzyme A hydrate
Purity
≥85% (UV, HPLC)
Packaging
10mg
Price
$81.3
Updated
2024/03/01
Sigma-Aldrich
Product number
C4282
Product name
Coenzyme A hydrate
Purity
≥85% (UV, HPLC)
Packaging
25mg
Price
$135
Updated
2024/03/01
Alfa Aesar
Product number
J13787
Product name
Coenzyme A trihydrate, free acid, Affymetrix/USB
Packaging
50mg
Price
$108.19
Updated
2021/12/16
Alfa Aesar
Product number
J13787
Product name
Coenzyme A trihydrate, free acid, Affymetrix/USB
Packaging
1g
Price
$1350.25
Updated
2021/12/16
Cayman Chemical
Product number
16147
Product name
Coenzyme A
Purity
≥98%
Packaging
10mg
Price
$74
Updated
2024/03/01
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Coenzyme A Chemical Properties,Usage,Production

Description

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Chemical Properties

yellowish lyophilisate

Uses

A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.

Uses

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Definition

ChEBI: Tetraanion of coenzyme A.

General Description

Coenzyme A is structurally composed of 2-aminoethanethiol, pantothenic acid and phosphorylated adenosine phosphate.

Biochem/physiol Actions

Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes.

Purification Methods

The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]

Coenzyme A Preparation Products And Raw materials

Raw materials

Adenine D-Ribose Cysteamine AMBERLITE(R) IRC-50 Adsorption resin Ion exchange resin column D-PANTOTHENIC ACID

Preparation Products

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View Lastest Price from Coenzyme A manufacturers

BINBO BIOLOGICAL CO.,LTD
Product
Coenzyme A 85-61-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
1000 kg
Release date
2024-04-05
Wuhan Boyuan Import & Export Co., LTD
Product
Acetyl Coenzyme 85-61-0
Price
US $50.00-30.00/KG
Min. Order
1KG
Purity
99.50%
Supply Ability
20tons
Release date
2023-07-10
Wuhan Boyuan Import & Export Co., LTD
Product
Coenzyme 85-61-0
Price
US $20.00-12.00/KG
Min. Order
1KG
Purity
99.50%
Supply Ability
20tons
Release date
2023-07-11

85-61-0, Coenzyme ARelated Search:

Coenzyme Q10 SUCCINYL COENZYME A SODIUM SALT COENZYME COENZYME A TRILITHIUM SALT ACETYL COENZYME A (C2:0) LITHIUM Acetyl coenzyme A sodium salt Cocarboxylase D-Biotin NADH, disodium salt NAD+ COENZYME Q9 LAUROYL COENZYME A C12:0 LITHIUM SALT,N-DODECANOYL COENZYME A LITHIUM SALT NADP, Disodium Salt Nadph tetrasodium salt MALONYL COENZYME A TETRALITHIUM SALT 2,3-Dimethoxy-5-methyl-p-benzoquinone COENZYME A SODIUM SALT N-DECANOYL COENZYME A (C10:0)

  • [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
  • CONENZYME A
  • Coenzyme a, free acid
  • Coenzyme A, free acid, lyophilized, min. 75% (enzym.)
  • COENZYME A FREE ACID FROM YEAST
  • Coenzyme A, free acid, lyophilized, 75%
  • Coenzyme A / Q0 / Q10
  • COENZYM A FREE ACID
  • COENZYME A (COA)
  • CoenzyMe A hydrate (free acid)
  • Coenzyme A hydrate,CoA
  • [5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
  • Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester
  • Aluzime
  • Coenzyme ASH
  • D-Coenzyme A
  • Coalip
  • Lucina
  • Thiol-CoA
  • Coenzyme A,75%,free acid, lyophilized
  • Coenzyme A, free acid, hydrate (COA)
  • coenzyme A(4-)
  • SHUIRUJIE
  • COENZYME A HYDRATE
  • COENZYME A
  • COA
  • COA-SH
  • Coenzyme A, Free Acid(CoA)
  • COENZYMEA 96%, TRILITH. D1GM
  • Coenzyme A USP/EP/BP
  • (((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy((R)-3-hydroxy-2,2-dimethyl-3-((2-((2-sulfanylethyl)carbamoyl)ethyl)carbamoyl)propoxy)phosphoryl)oxy)phosphoryl)oxy)methyl)oxolan-3-yl)oxy)phosphonic acid
  • Delivery Coenzyme
  • CoASH (Coenzyme A-SH), 80%
  • [[(2S,3R,4S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate
  • Coenzyme A (8CI, 9CI, ACI)
  • Acetyl Coenzyme
  • 85-61-0
  • 85-16-0
  • C21H36N7O16P3S
  • C21H36N7O16P3S3H2O
  • C21H38N7O17P3S
  • C21H32N7O16P3S
  • C21H36N7O16P3SxH2O
  • C21H36N7O16P3SH2O
  • Metabolic Libraries
  • Lipid Library
  • Nucleosides, Nucleotides, Oligonucleotides
  • Biochemicals and Reagents
  • BioChemical
  • Coenzyme A and Derivatives
  • Metabolomics
  • Vitamin series
  • 85-61-0