SUCCINYL COENZYME A SODIUM SALT
- Product Name
- SUCCINYL COENZYME A SODIUM SALT
- CAS No.
- 108347-97-3
- Chemical Name
- SUCCINYL COENZYME A SODIUM SALT
- Synonyms
- Succinyl CoA, Li-salt;succinyl coenzyme A sodium;SUCCINYL COENZYME A SODIUM SALT;Succinyl coenzyme A sodium salt >=85%;coenzyme A succinyl derivative, trisodium salt;Coenzyme A,S-(hydrogen butanedioate),sodium salt;Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)
- CBNumber
- CB2444570
- Molecular Formula
- C25H41N7NaO19P3S
- Formula Weight
- 891.6
- MOL File
- 108347-97-3.mol
SUCCINYL COENZYME A SODIUM SALT Property
- storage temp.
- -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S1129
- Product name
- Succinyl coenzyme A sodium salt
- Purity
- ≥85%
- Packaging
- 5mg
- Price
- $258
- Updated
- 2024/03/01
- Product number
- S1129
- Product name
- Succinyl coenzyme A sodium salt
- Purity
- ≥85%
- Packaging
- 25mg
- Price
- $973
- Updated
- 2024/03/01
- Product number
- 23297
- Product name
- Succinyl-Coenzyme A (sodium salt)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 23297
- Product name
- Succinyl-Coenzyme A (sodium salt)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 23297
- Product name
- Succinyl-Coenzyme A (sodium salt)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $376
- Updated
- 2024/03/01
SUCCINYL COENZYME A SODIUM SALT Chemical Properties,Usage,Production
Description
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle. It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis. Succinyl-CoA deficiency, caused by vitamin B12 deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.
Uses
Succinyl coenzyme A sodium salt has been used:
- for the nonenzymatic succinylation of lysine in vitro,
- as a substrate for adipic acid biosynthesis in recombinant E. coli
- in isocitrate dehydrogenase (ICDH)?treatment for the succinylation of proteins
- as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)
Biochem/physiol Actions
Succinyl CoA is an intermediate in the citric acid cycle. It is formed by α-ketoglutarate dehydrogenase by the decarboxylation of α-ketoglutarate. Succinyl CoA is also formed from propionyl CoA during the β-oxidation of odd-chain fatty acids. Succinyl CoA serves as a precursor in heme synthesis. It is also required for the oxidation of ketone bodies.
Purification Methods
If it should be purified further, then it should be dissolved in H2O (0.05g/mL) adjusted to pH 1 with 2M H2SO4 and extracted several times with Et2O. Excess Et2O is removed from the aqueous layer by bubbling N2 through it and is stored frozen at pH 1. When required, the pH should be adjusted to 7 with dilute NaOH and used within 2 weeks (samples should be frozen). Succinyl coenzyme A is estimated by the hydroxamic acid method [Hersch & Jencks J Biol Chem 242 3468 1967]. It is more stable in acidic than in neutral aqueous solutions, but neutral solutions can be stored at –15o with negligible decomposition. [Jordan & Laghai-Newton Methods Enzymol 123 435 1986, Beilstein 26 III/IV 3666.]
SUCCINYL COENZYME A SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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