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SUCCINYL COENZYME A SODIUM SALT

Product Name
SUCCINYL COENZYME A SODIUM SALT
CAS No.
108347-97-3
Chemical Name
SUCCINYL COENZYME A SODIUM SALT
Synonyms
Succinyl CoA, Li-salt;Succinyl-CoA-sodium-salt;succinyl coenzyme A sodium;SUCCINYL COENZYME A SODIUM SALT;Succinyl coenzyme A sodium salt >=85%;coenzyme A succinyl derivative, trisodium salt;Coenzyme A,S-(hydrogen butanedioate),sodium salt;Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)
CBNumber
CB2444570
Molecular Formula
C25H41N7NaO19P3S
Formula Weight
891.6
MOL File
108347-97-3.mol
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SUCCINYL COENZYME A SODIUM SALT Property

storage temp. 
-20°C
solubility 
PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S1129
Product name
Succinyl coenzyme A sodium salt
Purity
≥85%
Packaging
5mg
Price
$258
Updated
2024/03/01
Sigma-Aldrich
Product number
S1129
Product name
Succinyl coenzyme A sodium salt
Purity
≥85%
Packaging
25mg
Price
$973
Updated
2024/03/01
Cayman Chemical
Product number
23297
Product name
Succinyl-Coenzyme A (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
23297
Product name
Succinyl-Coenzyme A (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$201
Updated
2024/03/01
Cayman Chemical
Product number
23297
Product name
Succinyl-Coenzyme A (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$376
Updated
2024/03/01
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SUCCINYL COENZYME A SODIUM SALT Chemical Properties,Usage,Production

Description

Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle. It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis. Succinyl-CoA deficiency, caused by vitamin B12 deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.

Uses

Succinyl coenzyme A sodium salt has been used:

  • for the nonenzymatic succinylation of lysine in vitro,
  • as a substrate for adipic acid biosynthesis in recombinant E. coli
  • in isocitrate dehydrogenase (ICDH)?treatment for the succinylation of proteins
  • as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)

Biochem/physiol Actions

Succinyl CoA is an intermediate in the citric acid cycle. It is formed by α-ketoglutarate dehydrogenase by the decarboxylation of α-ketoglutarate. Succinyl CoA is also formed from propionyl CoA during the β-oxidation of odd-chain fatty acids. Succinyl CoA serves as a precursor in heme synthesis. It is also required for the oxidation of ketone bodies.

Purification Methods

If it should be purified further, then it should be dissolved in H2O (0.05g/mL) adjusted to pH 1 with 2M H2SO4 and extracted several times with Et2O. Excess Et2O is removed from the aqueous layer by bubbling N2 through it and is stored frozen at pH 1. When required, the pH should be adjusted to 7 with dilute NaOH and used within 2 weeks (samples should be frozen). Succinyl coenzyme A is estimated by the hydroxamic acid method [Hersch & Jencks J Biol Chem 242 3468 1967]. It is more stable in acidic than in neutral aqueous solutions, but neutral solutions can be stored at –15o with negligible decomposition. [Jordan & Laghai-Newton Methods Enzymol 123 435 1986, Beilstein 26 III/IV 3666.]

SUCCINYL COENZYME A SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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SUCCINYL COENZYME A SODIUM SALT Suppliers

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108347-97-3, SUCCINYL COENZYME A SODIUM SALTRelated Search:


  • SUCCINYL COENZYME A SODIUM SALT
  • succinyl coenzyme A sodium
  • coenzyme A succinyl derivative, trisodium salt
  • Succinyl CoA, Li-salt
  • Succinyl coenzyme A sodium salt >=85%
  • Coenzyme A,S-(hydrogen butanedioate),sodium salt
  • Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)
  • Succinyl-CoA-sodium-salt
  • 108347-97-3
  • C25H38N7Na2O19P3S
  • Metabolic Libraries
  • Lipid Library
  • Metabolomics
  • BioChemical
  • Acyl Transfer ReagentsEnzyme Substrates
  • Aminolevulinate synthase, 5-Saturated fatty acids and derivatives
  • Cofactors
  • Enzymes, Inhibitors, and Substrates
  • Esters
  • Fatty acyl CoAsMetabolic Pathways
  • Lipid Library
  • LipidMetabolomics
  • Metabolic Libraries
  • Metabolites and Cofactors on the Metabolic Pathways Chart
  • Substrates by Enzyme