SUCCINYL COENZYME A SODIUM SALT

Product Name: SUCCINYL COENZYME A SODIUM SALT
CAS No.: 108347-97-3
Chemical Name: SUCCINYL COENZYME A SODIUM SALT
Synonyms: Succinyl CoA, Li-salt;succinyl coenzyme A sodium;SUCCINYL COENZYME A SODIUM SALT;Succinyl coenzyme A sodium salt >=85%;coenzyme A succinyl derivative, trisodium salt;Coenzyme A,S-(hydrogen butanedioate),sodium salt;Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)
CBNumber: CB2444570
Molecular Formula: C25H41N7NaO19P3S
Formula Weight: 891.6
MOL File: 108347-97-3.mol

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SUCCINYL COENZYME A SODIUM SALT Property

storage temp.: -20°C
solubility: PBS (pH 7.2): 10 mg/ml
form: A crystalline solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S1129
Product name: Succinyl coenzyme A sodium salt
Purity: ≥85%
Packaging: 5mg
Price: $258
Updated: 2024/03/01

Sigma-Aldrich

Product number: S1129
Product name: Succinyl coenzyme A sodium salt
Purity: ≥85%
Packaging: 25mg
Price: $973
Updated: 2024/03/01

Cayman Chemical

Product number: 23297
Product name: Succinyl-Coenzyme A (sodium salt)
Purity: ≥95%
Packaging: 1mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 23297
Product name: Succinyl-Coenzyme A (sodium salt)
Purity: ≥95%
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 23297
Product name: Succinyl-Coenzyme A (sodium salt)
Purity: ≥95%
Packaging: 10mg
Price: $376
Updated: 2024/03/01

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SUCCINYL COENZYME A SODIUM SALT Chemical Properties,Usage,Production

Description

Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle. It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis. Succinyl-CoA deficiency, caused by vitamin B₁₂ deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.

Uses

Succinyl coenzyme A sodium salt has been used:

for the nonenzymatic succinylation of lysine in vitro,
as a substrate for adipic acid biosynthesis in recombinant E. coli
in isocitrate dehydrogenase (ICDH)?treatment for the succinylation of proteins
as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)

Biochem/physiol Actions

Succinyl CoA is an intermediate in the citric acid cycle. It is formed by α-ketoglutarate dehydrogenase by the decarboxylation of α-ketoglutarate. Succinyl CoA is also formed from propionyl CoA during the β-oxidation of odd-chain fatty acids. Succinyl CoA serves as a precursor in heme synthesis. It is also required for the oxidation of ketone bodies.

Purification Methods

If it should be purified further, then it should be dissolved in H2O (0.05g/mL) adjusted to pH 1 with 2M H2SO4 and extracted several times with Et2O. Excess Et2O is removed from the aqueous layer by bubbling N2 through it and is stored frozen at pH 1. When required, the pH should be adjusted to 7 with dilute NaOH and used within 2 weeks (samples should be frozen). Succinyl coenzyme A is estimated by the hydroxamic acid method [Hersch & Jencks J Biol Chem 242 3468 1967]. It is more stable in acidic than in neutral aqueous solutions, but neutral solutions can be stored at –15o with negligible decomposition. [Jordan & Laghai-Newton Methods Enzymol 123 435 1986, Beilstein 26 III/IV 3666.]

SUCCINYL COENZYME A SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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SUCCINYL COENZYME A SODIUM SALT Suppliers

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108347-97-3, SUCCINYL COENZYME A SODIUM SALTRelated Search:

Malic acid Oxobutanedioic acid NAD+ Acetyl coenzyme A sodium salt Methyl thiobutyrate Coenzyme A 3'-ADENYLIC ACID SUCCINYL COENZYME A SODIUM SALT S-ETHYL THIOPROPIONATE ADP N,S-DIACETYLCYSTEAMINE COENZYME A SODIUM SALT 2-(3-aminopropylamino)ethanethiol (-)-ADENOSIN-3'-PHOSPHORSAEURE HYDRAT 99 2,4-DIHYDROXY-3,3-DIMETHYLBUTANAMIDE 2'-DEOXYADENOSINE-3'-MONOPHOSPHATE 3-(BUTYLAMINO)PROPANAMIDE 2'-DEOXYADENOSINE-3'-MONOPHOSPHATE AMMONIUM SALT

SUCCINYL COENZYME A SODIUM SALT

succinyl coenzyme A sodium

coenzyme A succinyl derivative, trisodium salt

Succinyl CoA, Li-salt

Succinyl coenzyme A sodium salt >=85%

Coenzyme A,S-(hydrogen butanedioate),sodium salt

Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)

108347-97-3

C25H38N7Na2O19P3S

Metabolic Libraries

Lipid Library

Metabolomics

BioChemical

Acyl Transfer ReagentsEnzyme Substrates

Aminolevulinate synthase, 5-Saturated fatty acids and derivatives

Cofactors

Enzymes, Inhibitors, and Substrates

Esters

Fatty acyl CoAsMetabolic Pathways

Lipid Library

LipidMetabolomics

Metabolic Libraries

Metabolites and Cofactors on the Metabolic Pathways Chart

Substrates by Enzyme