Uses
ChemicalBook > CAS DataBase List > ADP

ADP

Uses
Product Name
ADP
CAS No.
58-64-0
Chemical Name
ADP
Synonyms
ADENOSINE DIPHOSPHATE;5’-adenylphosphoricacid;ADP;ANT 4;ADP-H;5'-ADP;ADP.H2;ADP,5-ADP;Etheno-ADP;5'--ADP·H2
CBNumber
CB5741946
Molecular Formula
C10H15N5O10P2
Formula Weight
427.2
MOL File
58-64-0.mol
More
Less

ADP Property

Melting point:
>145oC (dec.)
Boiling point:
196°C
Density 
2.49±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
pka
pK2: 4.2(-1);pK3: 7.20(-2) (25°C)
form 
Solid
color 
White to Off-White
Merck 
13,155
BRN 
67722
InChIKey
XTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
C(OP(=O)(O)OP(O)(O)=O)[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1O
EPA Substance Registry System
Adenosine 5'-(trihydrogen diphosphate) (58-64-0)
More
Less

Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
AU7467000
10-21
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
01905
Product name
Adenosine 5′-diphosphate
Purity
≥95% (HPLC)
Packaging
250MG-F
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
01905
Product name
Adenosine 5′-diphosphate
Purity
≥95% (HPLC)
Packaging
1G-F
Price
$370
Updated
2024/03/01
Sigma-Aldrich
Product number
01905
Product name
Adenosine 5′-diphosphate
Purity
≥95% (HPLC)
Packaging
250mg
Price
$113
Updated
2023/01/07
Sigma-Aldrich
Product number
01905
Product name
Adenosine 5′-diphosphate
Purity
≥95% (HPLC)
Packaging
1g
Price
$356
Updated
2023/01/07
Cayman Chemical
Product number
16778
Product name
Adenosine 5′-diphosphate
Purity
≥95%
Packaging
100mg
Price
$44
Updated
2024/03/01
More
Less

ADP Chemical Properties,Usage,Production

Uses

Adenosine-5'-diphosphate (ADP) is a central component of energy storage, metabolism, and signal transduction in vivo. It serves as a precursor for ATP and, in this capacity, is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

Uses

Adenosine 5′-diphosphate (5′-ADP or ADP) was used as a test compound for studying the endothelium-dependent vascular response in salt sensitive (DS) and salt resistant Dahl rats (DR). The product was used to study the different P2-purinergic receptor subtypes on canine vascular smooth muscle and endothelium.

Definition

ChEBI: A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.

Agricultural Uses

Adenosine diphosphate (ADP) is a phosphorus compound formed during the breakdown of adenosine triphosphate (ATP) by dephosphorylation. It is made of adenine, ribose, five carbon sugars and two phosphate groups. ADP acts as a source of energy in biochemical reactions.

Biological Activity

adenosine-5'-diphosphate is an agonist of purinergic receptors.purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules that are found in almost all mammalian tissues. within the field of purinergic signalling, these receptors have been implicated in learning and memory, locomotor and feeding behavior, and sleep. more specifically, purinergic receptors are involved in several cellular functions, such as proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion.

Biochem/physiol Actions

Adenosine 5′-diphosphate induces human platelet aggregation and non-competitively blocks the stimulated human platelet adenylate cyclase.

in vitro

adenosine 5'-diphosphate (adp) is an adenine nucleotide having two phosphate groups esterified to the sugar moiety at the 5’ position. adp is formed through dephosphorylation of adenosine 5’-triphosphate (atp) by atpases and can be converted back to atp by atp synthases. adp can also be metabolized to adenosine 5’-monophosphate (amp) and 2’-deoxyadenosine 5’-diphosphate (dadp). adp can modulate several receptors, such as activating certain purinergic receptors and inhibiting others, inhibiting rat ecto-5’nucleotidase (ki = 0.91 nm), as well as regulating the phosphorylation status of amp-activated protein kinase [1, 2].

Enzyme inhibitor

This adenine nucleotide (FWfree-acid = 504.16 g/mol; CAS 58-64-0; Molar Absorptivity = 15,400 M–1cm–1, l = 259 nm) is a product in ATPdependent transphosphorylases, phosphohydrolases, and molecular motors; as such, ADP often inhibits these enzymes. Enzymatic Phosphorylation: ADP is a substrate for adenylate kinase (Reaction: ADP2– + MeADP " MeATP2– + AMP) and other enzymes that stabilize ATP concentrations in prokaryotes [e.g., acetate kinase (Reaction: MgADP + Acetyl-phosphate ! MeATP2– + Acetate)] and eukaryotes [e.g., pyruvate kinase (Reaction: MgADP + Phosphoenolpyruvate ! MgATP2– + Pyruvate), creatine kinase (Reaction: MgADP + Creatine-phosphate ! MgATP2– + Creatine), arginine kinase (Reaction: MgADP + Arginine-phosphate ! MgATP2– + Arginine), and nuclecleotide diphosphate kinase (Reaction: ADP2– + MgGTP2– " MgATP2– + GDP2–)]. ATP Synthase: ADP is a primary substrate for the FOF1 ATP synthase (Reaction: MgADP + Pi + High Chemiosmotic Gradient Energization State ! MgATP2– + Low Chemiosmotic Gradient Energization State). ADP can also become entrapped within a catalytic site of the rotary motor, when proton motive is low, absent, or uncoupled, and its inhibitory action under such conditions is believed to prevent wasteful hydrolysis of ATP (Reaction: MgATP2– + H2O ? MgADP + Pi). Metal Ion Binding Properties: As a polyanion, ADP not only binds physiologic divalent cations Mg2+ and Ca2+, but also forms reversible complexes with Mn2+ and Co2+. For reversible complexation of ADP2– with a metal ion Me2+, (Reaction: ADP2– + Me2+ ! MeADP), Kformation = [MeADP]/[ADP2–]free[Me2+]free, indicating that [MeADP]/[ADP2– ]free = Kformation ′ [Me2+]free. In many cases, metal-free ADP is not a substrate and instead acts as a revesible inhibitor. Good experimental design therefore demands rigorous control of free metal ion concentration to control the ratio of metal-bound and metal-free forms. When exposed to Cr(III) at elevated temperature, ADP also forms ligand exchange-inert complexes with Cr3+. Platelet Aggregation: ADP is also a well-known activator of platelet aggregation, as mediated by the ADP receptors P2Y1, P2Y12 and P2X1. Upon conversion to adenosine by ecto-ADPases, platelet activation is inhibited by means of adenosine receptors. Target(s): Hydrogenomonas facilis ribulosediphosphate (RuDP) carboxylase and NADH-, ATP-dependent CO2 fixation; platelet (Na+/K+)-ATPase; hydrogen-ion transport in chloroplasts; pyruvate dehydrogenase kinase; 5-oxo-L-prolinase, or L-pyroglutamate hydrolase; a-NADHdependent reductase, rat liver microsomes; nitrogenase; Trypanosoma cruzi hexokinase; maize leaf acetyl-coenzyme A carboxylase; rat brain mitochondrial calcium-efflux; sarcoplasmic reticulum Ca2+ ATPase; Na+-Na+ exchange mediated by (Na+/K+)ATPase reconstituted into liposomes; nitrate and nitrite assimilation in Zea mays under dark conditions; PGE1-activated platelet adenylate cyclase in rats and rabbits; mitochondrial F1-ATPase, inactive complex formed upon binding ADP at a catalytic site; ATP-sensitive K+ channels, frog skeletal muscle; human 5-phosphoribosyl-1pyrophosphate synthetase; Crithidia fasciculata glutathionylspermidine synthetase; myosin V ATPase; cystic fibrosis transmembrane conductance regulator (ABC transporter) via its adenylate kinase activity; V type ATPase/synthase.

IC 50

67 nm for p2x2/3

Purification Methods

It is characterised by conversion to the acridine salt by addition of alcoholic acridine (1.1g in 50mL), filtering off the yellow salt and recrystallising from H2O. The salt has m 215o(dec), max 259nm ( 15,400) in 2O. [Baddiley & Todd J Chem Soc 648 1947, 582 1949, cf LePage Biochemical Preparations 1 1 1949, Martell & Schwarzenbach Helv Chim Acta 39 653 1956]. [Beilstein 26 III/IV 2369.]

References

1. azran, s.,frster, d.,danino, o., et al. highly efficient biocompatible neuroprotectants with dual activity as antioxidants and p2y receptor agonists. j. med. chem. 56(12), 4938-4952 (2013).2. jarvis, m.f.,bianchi, b.,uchic, j.t., et al. [3h]a-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human p2x2/3 and p2x3 receptors. journal of pharmacology and experimental therapeutics 310(1), 407-416 (2004).

ADP Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ADP Suppliers

Wuhan penglei Biotechnology Co., Ltd
Tel
15871464247
Email
1545569349@QQ.COM
Country
China
ProdList
734
Advantage
58
Nanjing UltraPure Biotech Co., Ltd.
Tel
025-82263158 13851993283
Fax
025-82263168
Email
2842979086@qq.com
Country
China
ProdList
241
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4554
Advantage
62
More
Less

View Lastest Price from ADP manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Adenosine 5'-diphosphate;ADP,5-ADP 58-64-0
Price
US $0.00-0.00/g
Min. Order
10000g
Purity
99.0%min. HPLC
Supply Ability
1000kg
Release date
2024-11-21
Hebei Weibang Biotechnology Co., Ltd
Product
Adenosine 5’-diphosphate 58-64-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-05
Hangzhou Meiya Pharmaceutical Co Ltd
Product
Adenosine 5’-diphosphate(ADP-H) 58-64-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥95.0%
Supply Ability
20MT
Release date
2024-02-07

58-64-0, ADPRelated Search:


  • 5'-ADP
  • ADP
  • ADENOSINE-5'-DIPHOSPHORIC ACID
  • ADENOSINE 5'-DIPHOSPHATE
  • ADENOSINE DIPHOSPHATE
  • 5’-adenylphosphoricacid
  • adenosine,5’-(trihydrogendiphosphate)
  • adp(nucleotide)
  • ADENOSINE-5'-DIPHOSPHATE (ADP)
  • [[5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
  • 1-Deoxy-1-(3H-imidazo[2,1-i]purin-3-yl)-β-D-ribofuranose 5-diphosphoric acid
  • Etheno-ADP
  • 9-{5-o-[Hydroxy(phosphonooxy)phosphoryl]-B-D-glycero-pentofuranosyl}-9H-purin-6-amine
  • 9H-Purin-6-amine, 9-[5-o-[hydroxy(phosphonooxy)phosphinyl]-beta-D-glycero-pentofuranosyl]-
  • Adenosine 5'-(trihydrogen diphosphate) (9ci)
  • Adenosine 5'-(trihydrogen pyrophosphate) (8ci)
  • Adenosine 5'-diphosphate,>=95% ,HPLC
  • Adenosine 5’-diphosp
  • Adenosine diphosphate crude,lithium salt,sodium
  • Adenosine-5'-diphosphate disodium salt (ADP)
  • Adenosine-5''-diphosphoric acid (and/or unspecified salts)
  • adenosine,5’-(trihydrogenpyrophosphate)
  • adenosine5’-(trihydrogendiphosphate)
  • adenosine5’-pyrophosphate
  • adenosine5’-pyrophosphoricacid
  • adenosinediphosphoricacid
  • adenosinepyrophosphate
  • Adenosine-5'-diphosphate, Free acid
  • ADP.H2
  • adenine nucleotide translocator 2
  • adenine nucleotide translocator 3
  • ATP carrier 3
  • Adenine nucleotide translocator 4
  • ADP/ATP translocase 4
  • ANT 4
  • ATP carrier protein 4
  • Adenosine 5'-(trihydrogen diphosphate)/ADP
  • 5'--ADP·H2
  • ADP, CID6022
  • Adenosine 5'-Diphosphate-13C5
  • Adenosine 5'-diphosphate, ≥98% (HPLC)
  • Adenosine 5'-diphosphate, 100mM sodium salt solution
  • ADP, 100mM sodium salt solution
  • ADP USP/EP/BP
  • ADP,5-ADP
  • Adenosine 5'-diphosphate (5'-ADP)
  • Adenosine Impurity 3
  • TIANFU CHEM-ADP(adenosine,5’-(trihydrogenpyrophosphate))
  • ((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
  • ADP-H
  • Adenosine 5'-diphosphate(ADP-H)
  • Adenosine 5′-diphosphate cyclohexylammonium salt
  • Adenosine 5'-diphosphate
  • adenosine 5'-(trihydrogen diphosphate)
  • 5'-diphosphate
  • 58-64-0
  • C513C5H15N5O10P2
  • C10H17N5O11P2