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BOC-ALA-N(OCH3)CH3

Product Name
BOC-ALA-N(OCH3)CH3
CAS No.
87694-49-3
Chemical Name
BOC-ALA-N(OCH3)CH3
Synonyms
EOS-60721;Boc-Ala-N-O;Boc-Ala-NMe(OMe);BOC-ALA-N(OCH3)CH3;Boc-L-Ala-N(OCH3)CH3;BOC-ALA-N(OCH3)CH3 USP/EP/BP;BOC-L-ALANINE N-METHOXY-N-METHYL AMIDE;Boc-L-alanine-N'-methoxy-N'-carboxamide;N-Boc-L-alanine N'-Methoxy-N'-methylamide;(S)-2-(Boc-aMino)-N-Methoxy-N-MethylpropanaMide
CBNumber
CB4327015
Molecular Formula
C10H20N2O4
Formula Weight
232.28
MOL File
87694-49-3.mol
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BOC-ALA-N(OCH3)CH3 Property

Melting point:
148-153 °C (lit.)
Density 
1.070
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
11.19±0.46(Predicted)
form 
Crystalline Powder or Powder
color 
White to off-white
optical activity
[α]24/D 26°, c = 1 in methanol
InChI
InChI=1/C10H20N2O4/c1-7(8(13)12(5)15-6)11-9(14)16-10(2,3)4/h7H,1-6H3,(H,11,14)/t7-/s3
InChIKey
PWQIGBOSLQHOBT-ZETCQYMHSA-N
SMILES
C(OC(C)(C)C)(=O)N[C@@H](C)C(N(OC)C)=O |&1:8,r|
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Safety

WGK Germany 
3
HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
458457
Product name
N-(tert-Butoxycarbonyl)-L-alanine N′-methoxy-N′-methylamide
Purity
98%
Packaging
5g
Price
$85
Updated
2023/06/20
TCI Chemical
Product number
B6019
Product name
N-(tert-Butoxycarbonyl)-L-alanine N'-Methoxy-N'-methylamide
Packaging
1G
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
B6019
Product name
N-(tert-Butoxycarbonyl)-L-alanine N'-Methoxy-N'-methylamide
Packaging
5G
Price
$114
Updated
2025/07/31
TRC
Product number
B703600
Product name
tert-ButylN-[(1S)-2-[methoxy(methyl)amino]-1-methyl-2-oxoethyl]carbamate
Packaging
1g
Price
$60
Updated
2021/12/16
Usbiological
Product number
264810
Product name
Boc-L-alanine N-methoxy-N-methyl amide
Packaging
2g
Price
$358
Updated
2021/12/16
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BOC-ALA-N(OCH3)CH3 Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Reduced by LiAlH4 to give the corresponding Boc-amino acid aldehyde.

Uses

α-Amino Weinreb amide.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

15761-38-3

6638-79-5

146553-06-2

1. In a 100 mL oven-dried round-bottomed flask, N-tert-butoxycarbonyl-L-alanine (3.0 g, 15.8 mmol), anhydrous dichloromethane (60 mL), and N,N-diisopropylethylamine (2.5 mL, 14.2 mmol) were added, and the mixture was cooled to 0 °C. 2. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (3.7 g, 19.0 mmol) and 1-hydroxybenzotriazole (2.6 g, 19.0 mmol) were added sequentially at 0 °C and stirred for 10 min. 3. N,O-dimethylhydroxylamine hydrochloride (1.9 g, 19.0 mmol) and N,N-diisopropylethylamine (3.3 mL, 19.0 mmol) were added, and stirring was continued for 1 hr at 0 °C, then the reaction was raised to 25 °C for 16 hr. 4. After completion of the reaction, the reaction mixture was diluted with dichloromethane (300 mL) and the organic layer was washed sequentially with 2N hydrochloric acid (3 x 180 mL), saturated sodium bicarbonate solution (2 x 180 mL) and brine (2 x 180 mL). 5. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a white solid product (3.6 g, 99% yield). 6. The above product (3.7 g, 15.8 mmol) was dissolved in anhydrous tetrahydrofuran (100 mL) and cooled to 0°C. The product was added to the mixture. 7. Lithium aluminum hydride (660 mg, 17.4 mmol) was added and stirred for 20 min. 8. Upon completion of the reaction, the organic layer was quenched with 5% hydrochloric acid solution, evaporated and the aqueous phase was extracted with ethyl acetate (3 x 30 mL). 9. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give N-(tert-butoxycarbonyl)-L-alanine-N-methoxy-N-methylamide white solid (2.6 g, 94% yield).

References

[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 34, p. 8957 - 8960
[2] Angew. Chem., 2013, vol. 125, # 34, p. 9126 - 9129,4
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2014, vol. 57, # 4, p. 275 - 278
[4] Organic Letters, 2002, vol. 4, # 16, p. 2665 - 2668
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3582 - 3586

BOC-ALA-N(OCH3)CH3 Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-ALA-N(OCH3)CH3 Suppliers

Americas 1 Belgium 1 China 116 Europe 1 France 1 Germany 5 India 5 Japan 1 Switzerland 1 United Kingdom 6 United States 30 Global 168
ShangHai ShuaiDian MEDICAL TECHNOLOGY CO.,LTD.
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15821556986
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Amatek Scientific Co. Ltd.
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Shandong Lonyuta Pharmaceutical Technology Co., Ltd
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0534-2152677 17862520650
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China
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Shanghai Send Pharmaceutical Technology Co., Ltd.
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+86-021-50266790 Q2086672224
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847-367-3680
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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Accela ChemBio Co.,Ltd.
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View Lastest Price from BOC-ALA-N(OCH3)CH3 manufacturers

Career Henan Chemical Co
Product
BOC-ALA-N(OCH3)CH3 87694-49-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-03

87694-49-3, BOC-ALA-N(OCH3)CH3Related Search:

N-(3-DIMETHYLAMINOPROPYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZAMIDE N-(6-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-naphthalen-2-yl)MethanesulfonaMide N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide N-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)propan-1-amine 3-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester 3-(Diethylcarbamoyl)-2-fluorophenylboronic acid,pinacol ester N-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropyl)acetamide 4-(2-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PHENOXY]-ETHYL)-MORPHOLINE 4-(N-PHENYLAMINOMETHYL)PHENYLBORONIC ACID 4-Acetamido-3-(trifluoromethy)phenylboronic acid, N-(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)propan-1-amine N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-amine N-(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide 3-(N,N-DIMETHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER 3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester 3-(4-FLUOROPHENYL)AMINOCARBONYLPHENYLBORONIC ACID PINACOL ESTER

  • Boc-L-Ala-N(OCH3)CH3
  • Boc-L-alanineN-methoxy-N-methyl amide≥ 98% (HPLC)
  • BOC-L-ALANINE N-METHOXY-N-METHYL AMIDE
  • BOC-ALA-N(OCH3)CH3
  • N-ALPHA-T-BOC-L-ALANINE N-METHOXY-N-METHYL AMIDE
  • N-(tert-butoxycarbonyl)-L-alanine N'-methoxy-N'-M
  • N-[(1S)-2-(Methoxymethylamino)-1-methyl-2-oxoethyl]-carbamic acid tert-butyl ester
  • N~2~-(tert-butoxycarbonyl)-N-Methoxy-N-Methyl-L-alaninaMide
  • (S)-2-(Boc-aMino)-N-Methoxy-N-MethylpropanaMide
  • tert-butyl(S)-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate
  • Boc-Ala-NMe(OMe)
  • Carbamic acid, [2-(methoxymethylamino)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (S)-
  • CarbaMic acid,N-[(1S)-2-(MethoxyMethylaMino)-1-Methyl-2-oxoethyl]-, 1,1-diMethylethyl ester
  • t-butyl N-{(1S)-2-[Methoxy(Methyl)aMino]-1-Methyl-2-oxoethyl}carbaMate
  • (S)-[2-(Methoxymethylamino)-1-methyl-2-oxoethyl]-carbamic acid 1,1-dimethylethyl ester
  • [(1S)-2-(Methoxymethylamino)-1-methyl-2-oxoethyl]-carbamic acid 1,1-dimethylethyl ester
  • EOS-60721
  • (S)-tert-butyl 1-(Methoxy(Methyl)aMino)-1-oxopropan-2-ylcarbaMate
  • Boc-Ala-N-O
  • N-Boc-L-alanine N'-Methoxy-N'-methylamide
  • BOC-ALA-N(OCH3)CH3 USP/EP/BP
  • tert-Butyl N-[(1S)-2-[methoxy(methyl)amino]-1-methyl-2-oxoethyl]carbamate
  • N-Methoxy-N-methyl-N2-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-alaninamide
  • N-tert -Butoxycarbonyl-L-alanine N' -methoxy-N' -methylam
  • N-(tert-Butoxycarbonyl)-L-alanine N'-Methoxy-N'-methylamide
  • Boc-L-alanine-N'-methoxy-N'-carboxamide
  • <i>N</i>-(<i>tert</i>-Butoxycarbonyl)-<sc>L</sc>-alanine <i>N</i>′-methoxy-<i>N</i>′-methylamide
  • N-(tert-Butoxycarbonyl)-L-alanine N′-methoxy-N′-methylamide, CAS 87694-49-3
  • 87694-49-3
  • CH3CHNHCO2CCH33CONOCH3CH3
  • Alanine
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Alanine
  • Amino Acid Derivatives
  • Peptide Synthesis