ChemicalBook > CAS DataBase List > BML-190

BML-190

Product Name
BML-190
CAS No.
2854-32-2
Chemical Name
BML-190
Synonyms
IMMA;BML-190;BML-190 USP/EP/BP;BML-190;BML 190;BML190;Indomethacin morpholinamide;INDOMETHACIN MORPHOLINYLAMIDE;Indomethacin Morpholinylamide Impurity;BML-190 (Indomethacin morpholinylamide;BML 190; BML190; IMMA; INDOMETHACIN MORPHOLINYLAMIDE;N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine
CBNumber
CB4328320
Molecular Formula
C23H23ClN2O4
Formula Weight
426.89
MOL File
2854-32-2.mol
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BML-190 Property

Melting point:
162.0-163.5 °C
Boiling point:
586.7±50.0 °C(Predicted)
Density 
1.31
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: >20mg/mL
form 
solid
pka
-0.97±0.20(Predicted)
color 
off-white
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Safety

WGK Germany 
3
Toxicity
rat,LDLo,oral,40mg/kg (40mg/kg),Bollettino Chimico Farmaceutico. Vol. 114, Pg. 309, 1975.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
70275
Product name
IMMA
Purity
≥98%
Packaging
5mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
70275
Product name
IMMA
Purity
≥98%
Packaging
10mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
70275
Product name
IMMA
Purity
≥98%
Packaging
50mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
70275
Product name
IMMA
Purity
≥98%
Packaging
100mg
Price
$341
Updated
2024/03/01
Usbiological
Product number
254783
Product name
BML-190
Packaging
10mg
Price
$353
Updated
2021/12/16
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BML-190 Chemical Properties,Usage,Production

Uses

BML-190, is a selective cannabinoid CB2 receptor, and it is also used for treatment of organophosphate and carbamate toxicity.

Definition

ChEBI: 2-[1-[(4-chlorophenyl)-oxomethyl]-5-methoxy-2-methyl-3-indolyl]-1-(4-morpholinyl)ethanone is a N-acylindole.

Biological Activity

Potent and selective CB 2 receptor ligand (K i values are 435 nM and > 2 μ M for CB 2 and CB 1 respectively).

References

[1] new dc, wong yh. bml-190 and am251 act as inverse agonists at the human cannabinoid cb2 receptor: signalling via camp and inositol phosphates. febs lett. 2003 feb 11;536(1-3):157-60. pubmed pmid: 12586356.
[2] chang yh, lee st, lin ww. effects of cannabinoids on lps-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. j cell biochem. 2001;81(4):715-23. pubmed pmid: 11329626.
[3] klegeris a, bissonnette cj, mcgeer pl. reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type cb2 receptor. br j pharmacol. 2003 jun;139(4):775-86. pubmed pmid: 12813001; pubmed central pmcid: pmc1573900.
[4] scutt a, williamson em. cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via cb2 receptors. calcif tissue int. 2007 jan;80(1):50-9. epub 2007 jan 4. pubmed pmid: 17205329.
[5] zhang l, zhang x, wu p, li h, jin s, zhou x, li y, ye d, chen b, wan j. bml-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis. inflamm res. 2008 apr;57(4):157-62. doi: 10. 1007/s00011-007-7141-z. pubmed pmid: 18648754.
[6] zhang q, ma p, cole rb, wang g. in vitro metabolism of indomethacin morpholinylamide (bml-190), an inverse agonist for the peripheral cannabinoid receptor (cb(2)) in rat liver microsomes. eur j pharm sci. 2010 sep 11;41(1):163-72. doi: 10.1016/j.ejps.2010.06.004. epub 2010 jun 11. pubmed pmid: 20542112; pubmed central pmcid: pmc2907062.

BML-190 Preparation Products And Raw materials

Raw materials

Preparation Products

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BML-190 Suppliers

China 78 Europe 1 France 1 Germany 3 India 1 South Korea 1 Switzerland 2 United Kingdom 2 United States 21 Global 110
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from BML-190 manufacturers

Career Henan Chemical Co
Product
BML-190 2854-32-2
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-30

2854-32-2, BML-190Related Search:

AM 251 R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE ARACHIDONIC ACID-(2-AMINOETHYL)-ESTER HYDROCHLORIDE ARACHIDONAMIDE N,N-Dimethyl-5-methoxytryptamine Bufotenine 5-HYDROXYINDOLE-3-ACETAMIDE 5-Methoxytryptamine Indole-3-acetic acid 2-METHYL-5-HYDROXYTRYPTAMINE 5-METHOXY-N,N-DIETHYLTRYPTAMINE(5-MEO-DET) N-ACETYL-6-METHOXYTRYPTAMINE 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE 2-(5-METHOXY-1H-INDOL-3-YL)-ACETAMIDE BML-190 CHEMBRDG-BB 5102396 N-ACETYL-5-HYDROXYTRYPTAMINE Benanserine

  • IMMA
  • INDOMETHACIN MORPHOLINYLAMIDE
  • BML-190
  • 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, MORPHOLINEAMIDE
  • 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1-[2-(4-MORPHOLINYL)-2-OXOETHYL]-1H-INDOLE
  • 1h-indole,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-(2-(4-morpholinyl)-2-oxoe
  • 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl)acetyl)-morpholin
  • BML-190, N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1-[2-(morpholinyl)-2-oxoethyl]-1H-indole
  • 2-(1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indol-3-yl)-1-Morpholinoethanone
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole
  • 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-[(morpholinocarbonyl)methyl]-indole
  • 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone
  • Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-
  • N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine
  • Indomethacin morpholinamide
  • BML-190;BML 190;BML190
  • BML 190; BML190; IMMA; INDOMETHACIN MORPHOLINYLAMIDE
  • Indomethacin Morpholinylamide Impurity
  • BML-190 USP/EP/BP
  • BML-190 (Indomethacin morpholinylamide
  • 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl]-1-morpholinoethanone
  • 2854-32-2
  • C23H23ClN2O4
  • Inhibitors
  • Cannabinoid receptor