ChemicalBook > CAS DataBase List > BML-190

BML-190

Product Name: BML-190
CAS No.: 2854-32-2
Chemical Name: BML-190
Synonyms: IMMA;BML-190;BML-190 ，S2854;BML-190 USP/EP/BP;BML-190;BML 190;BML190;BML-190, 10 mM in DMSO;Indomethacin morpholinamide;INDOMETHACIN MORPHOLINYLAMIDE;Indomethacin Morpholinylamide Impurity;BML-190 (Indomethacin morpholinylamide
CBNumber: CB4328320
Molecular Formula: C23H23ClN2O4
Formula Weight: 426.89
MOL File: 2854-32-2.mol

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BML-190 Property

Melting point:: 162.0-163.5 °C
Boiling point:: 586.7±50.0 °C(Predicted)
Density: 1.31
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: >20mg/mL
form: solid
pka: -0.97±0.20(Predicted)
color: off-white

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Safety

WGK Germany: 3
Toxicity: rat,LDLo,oral,40mg/kg (40mg/kg),Bollettino Chimico Farmaceutico. Vol. 114, Pg. 309, 1975.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70275
Product name: IMMA
Purity: ≥98%
Packaging: 5mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 70275
Product name: IMMA
Purity: ≥98%
Packaging: 10mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 70275
Product name: IMMA
Purity: ≥98%
Packaging: 50mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 70275
Product name: IMMA
Purity: ≥98%
Packaging: 100mg
Price: $341
Updated: 2024/03/01

Usbiological

Product number: 254783
Product name: BML-190
Packaging: 10mg
Price: $353
Updated: 2021/12/16

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BML-190 Chemical Properties,Usage,Production

Uses

BML-190, is a selective cannabinoid CB2 receptor, and it is also used for treatment of organophosphate and carbamate toxicity.

Definition

ChEBI: 2-[1-[(4-chlorophenyl)-oxomethyl]-5-methoxy-2-methyl-3-indolyl]-1-(4-morpholinyl)ethanone is a N-acylindole.

Biological Activity

Potent and selective CB 2 receptor ligand (K i values are 435 nM and > 2 μ M for CB 2 and CB 1 respectively).

References

[1] new dc, wong yh. bml-190 and am251 act as inverse agonists at the human cannabinoid cb2 receptor: signalling via camp and inositol phosphates. febs lett. 2003 feb 11;536(1-3):157-60. pubmed pmid: 12586356.
[2] chang yh, lee st, lin ww. effects of cannabinoids on lps-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. j cell biochem. 2001;81(4):715-23. pubmed pmid: 11329626.
[3] klegeris a, bissonnette cj, mcgeer pl. reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type cb2 receptor. br j pharmacol. 2003 jun;139(4):775-86. pubmed pmid: 12813001; pubmed central pmcid: pmc1573900.
[4] scutt a, williamson em. cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via cb2 receptors. calcif tissue int. 2007 jan;80(1):50-9. epub 2007 jan 4. pubmed pmid: 17205329.
[5] zhang l, zhang x, wu p, li h, jin s, zhou x, li y, ye d, chen b, wan j. bml-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis. inflamm res. 2008 apr;57(4):157-62. doi: 10. 1007/s00011-007-7141-z. pubmed pmid: 18648754.
[6] zhang q, ma p, cole rb, wang g. in vitro metabolism of indomethacin morpholinylamide (bml-190), an inverse agonist for the peripheral cannabinoid receptor (cb(2)) in rat liver microsomes. eur j pharm sci. 2010 sep 11;41(1):163-72. doi: 10.1016/j.ejps.2010.06.004. epub 2010 jun 11. pubmed pmid: 20542112; pubmed central pmcid: pmc2907062.

BML-190 Preparation Products And Raw materials

Raw materials

Preparation Products

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BML-190 Suppliers

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View Lastest Price from BML-190 manufacturers

Career Henan Chemical Co

Product: BML-190 2854-32-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-30

2854-32-2, BML-190Related Search:

AM 251 R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE ARACHIDONIC ACID-(2-AMINOETHYL)-ESTER HYDROCHLORIDE ARACHIDONAMIDE N,N-Dimethyl-5-methoxytryptamine Bufotenine 5-HYDROXYINDOLE-3-ACETAMIDE 5-Methoxytryptamine Indole-3-acetic acid 2-METHYL-5-HYDROXYTRYPTAMINE 5-METHOXY-N,N-DIETHYLTRYPTAMINE(5-MEO-DET) N-ACETYL-6-METHOXYTRYPTAMINE 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE 2-(5-METHOXY-1H-INDOL-3-YL)-ACETAMIDE BML-190 CHEMBRDG-BB 5102396 N-ACETYL-5-HYDROXYTRYPTAMINE Benanserine

IMMA

INDOMETHACIN MORPHOLINYLAMIDE

BML-190

1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, MORPHOLINEAMIDE

1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1-[2-(4-MORPHOLINYL)-2-OXOETHYL]-1H-INDOLE

1h-indole,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-(2-(4-morpholinyl)-2-oxoe

4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl)acetyl)-morpholin

BML-190, N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1-[2-(morpholinyl)-2-oxoethyl]-1H-indole

2-(1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indol-3-yl)-1-Morpholinoethanone

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole

1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-[(morpholinocarbonyl)methyl]-indole

2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone

Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-

N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine

Indomethacin morpholinamide

BML-190;BML 190;BML190

BML 190; BML190; IMMA; INDOMETHACIN MORPHOLINYLAMIDE

Indomethacin Morpholinylamide Impurity

BML-190 USP/EP/BP

BML-190 (Indomethacin morpholinylamide

2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl]-1-morpholinoethanone

BML-190, 10 mM in DMSO

BML-190 ，S2854

2854-32-2

C23H23ClN2O4

Inhibitors

Cannabinoid receptor