BML-190
- Product Name
- BML-190
- CAS No.
- 2854-32-2
- Chemical Name
- BML-190
- Synonyms
- IMMA;BML-190;BML-190 USP/EP/BP;BML-190;BML 190;BML190;Indomethacin morpholinamide;INDOMETHACIN MORPHOLINYLAMIDE;Indomethacin Morpholinylamide Impurity;BML-190 (Indomethacin morpholinylamide;BML 190; BML190; IMMA; INDOMETHACIN MORPHOLINYLAMIDE;N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine
- CBNumber
- CB4328320
- Molecular Formula
- C23H23ClN2O4
- Formula Weight
- 426.89
- MOL File
- 2854-32-2.mol
BML-190 Property
- Melting point:
- 162.0-163.5 °C
- Boiling point:
- 586.7±50.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: >20mg/mL
- form
- solid
- pka
- -0.97±0.20(Predicted)
- color
- off-white
Safety
- WGK Germany
- 3
- Toxicity
- rat,LDLo,oral,40mg/kg (40mg/kg),Bollettino Chimico Farmaceutico. Vol. 114, Pg. 309, 1975.
N-Bromosuccinimide Price
- Product number
- 70275
- Product name
- IMMA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 70275
- Product name
- IMMA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 70275
- Product name
- IMMA
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- 70275
- Product name
- IMMA
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 254783
- Product name
- BML-190
- Packaging
- 10mg
- Price
- $353
- Updated
- 2021/12/16
BML-190 Chemical Properties,Usage,Production
Uses
BML-190, is a selective cannabinoid CB2 receptor, and it is also used for treatment of organophosphate and carbamate toxicity.
Definition
ChEBI: 2-[1-[(4-chlorophenyl)-oxomethyl]-5-methoxy-2-methyl-3-indolyl]-1-(4-morpholinyl)ethanone is a N-acylindole.
Biological Activity
Potent and selective CB 2 receptor ligand (K i values are 435 nM and > 2 μ M for CB 2 and CB 1 respectively).
References
[1] new dc, wong yh. bml-190 and am251 act as inverse agonists at the human cannabinoid cb2 receptor: signalling via camp and inositol phosphates. febs lett. 2003 feb 11;536(1-3):157-60. pubmed pmid: 12586356.
[2] chang yh, lee st, lin ww. effects of cannabinoids on lps-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. j cell biochem. 2001;81(4):715-23. pubmed pmid: 11329626.
[3] klegeris a, bissonnette cj, mcgeer pl. reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type cb2 receptor. br j pharmacol. 2003 jun;139(4):775-86. pubmed pmid: 12813001; pubmed central pmcid: pmc1573900.
[4] scutt a, williamson em. cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via cb2 receptors. calcif tissue int. 2007 jan;80(1):50-9. epub 2007 jan 4. pubmed pmid: 17205329.
[5] zhang l, zhang x, wu p, li h, jin s, zhou x, li y, ye d, chen b, wan j. bml-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis. inflamm res. 2008 apr;57(4):157-62. doi: 10. 1007/s00011-007-7141-z. pubmed pmid: 18648754.
[6] zhang q, ma p, cole rb, wang g. in vitro metabolism of indomethacin morpholinylamide (bml-190), an inverse agonist for the peripheral cannabinoid receptor (cb(2)) in rat liver microsomes. eur j pharm sci. 2010 sep 11;41(1):163-72. doi: 10.1016/j.ejps.2010.06.004. epub 2010 jun 11. pubmed pmid: 20542112; pubmed central pmcid: pmc2907062.
BML-190 Preparation Products And Raw materials
Raw materials
Preparation Products
BML-190 Suppliers
View Lastest Price from BML-190 manufacturers
- Product
- BML-190 2854-32-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-30