NIGERICIN SODIUM SALT
- Product Name
- NIGERICIN SODIUM SALT
- CAS No.
- 28380-24-7
- Chemical Name
- NIGERICIN SODIUM SALT
- Synonyms
- x-464;Helix c;HELIXIN C;NIGERICIN;Aids003767;Aids-003767;AZALOMYCIN M;NIGERICIN NA;POLYETHERIN A;Antibiotic M 2
- CBNumber
- CB4331016
- Molecular Formula
- C40H68O11
- Formula Weight
- 724.96
- MOL File
- 28380-24-7.mol
NIGERICIN SODIUM SALT Property
- Melting point:
- 183.5-185°
- alpha
- D24 +36.2° (c = 0.842 in CHCl3)
- Boiling point:
- 779.9±60.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- chloroform: 10 mg/mL, clear, colorless
- pka
- 4.39±0.10(Predicted)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-36/37/39-45-36
- RIDADR
- UN 3462 6.1/PG 3
- WGK Germany
- 3
- RTECS
- QT6840000
- F
- 10
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29419090
- Toxicity
- LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0003572
- Product name
- NIGERICIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $673.61
- Updated
- 2021/12/16
- Product number
- API0003572
- Product name
- NIGERICIN
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $686.65
- Updated
- 2021/12/16
- Product number
- API0003572
- Product name
- NIGERICIN
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $737.58
- Updated
- 2021/12/16
- Product number
- 2066
- Product name
- Nigericin
- Packaging
- 1g
- Price
- $3250
- Updated
- 2021/12/16
- Product number
- 2066
- Product name
- Nigericin
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
NIGERICIN SODIUM SALT Chemical Properties,Usage,Production
Uses
Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.
Definition
ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.
NIGERICIN SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from NIGERICIN SODIUM SALT manufacturers
- Product
- NIGERICIN SODIUM SALT 28380-24-7
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2022-10-18
- Product
- NIGERICIN SODIUM SALT 28380-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 200kg
- Release date
- 2020-01-12