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NIGERICIN SODIUM SALT

Product Name
NIGERICIN SODIUM SALT
CAS No.
28380-24-7
Chemical Name
NIGERICIN SODIUM SALT
Synonyms
x-464;Helix c;HELIXIN C;NIGERICIN;Aids003767;Aids-003767;AZALOMYCIN M;NIGERICIN NA;POLYETHERIN A;Antibiotic M 2
CBNumber
CB4331016
Molecular Formula
C40H68O11
Formula Weight
724.96
MOL File
28380-24-7.mol
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NIGERICIN SODIUM SALT Property

Melting point:
183.5-185°
alpha 
D24 +36.2° (c = 0.842 in CHCl3)
Boiling point:
779.9±60.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
chloroform: 10 mg/mL, clear, colorless
pka
4.39±0.10(Predicted)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 3462 6.1/PG 3
WGK Germany 
3
RTECS 
QT6840000
F 
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29419090
Toxicity
LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0003572
Product name
NIGERICIN
Purity
95.00%
Packaging
5MG
Price
$673.61
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003572
Product name
NIGERICIN
Purity
95.00%
Packaging
10MG
Price
$686.65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003572
Product name
NIGERICIN
Purity
95.00%
Packaging
25MG
Price
$737.58
Updated
2021/12/16
AvaChem
Product number
2066
Product name
Nigericin
Packaging
1g
Price
$3250
Updated
2021/12/16
AvaChem
Product number
2066
Product name
Nigericin
Packaging
5mg
Price
$45
Updated
2021/12/16
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NIGERICIN SODIUM SALT Chemical Properties,Usage,Production

Uses

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Definition

ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.

NIGERICIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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NIGERICIN SODIUM SALT Suppliers

China 90 Europe 1 Germany 4 India 1 Japan 1 Switzerland 2 United Kingdom 6 United States 18 Global 123
Raw material medicin reagent co.,Ltd
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View Lastest Price from NIGERICIN SODIUM SALT manufacturers

Career Henan Chemical Co
Product
NIGERICIN SODIUM SALT 28380-24-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-99.9%
Supply Ability
200kg
Release date
2020-01-12

28380-24-7, NIGERICIN SODIUM SALTRelated Search:

1,16-HEXADECANEDIOL n-Octacosane NIGERICIN SODIUM SALT TRICOSANOIC ACID CAPRIC ACID SODIUM SALT N-NONACOSANE 1-TERT-BUTOXY-2-PROPANOL 3,6,9,12-tetraoxahexadecan-1-ol 11-HENEICOSANOL (R)-1,2-DODECANEDIOL 1-HEXACOSANOL 2-(OCTADECYLOXY)ETHANOL N-CAPROIC ACID SODIUM SALT TRI(PROPYLENE GLYCOL) PROPYL ETHER Dipropylene Glycol Dimethyl Ether Sodium stearate Nigericin sodium salt 1,3,3-TRIMETHOXYBUTANE

  • (2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid
  • 28643-80-3 (Sodium salt)
  • Aids003767
  • Aids-003767
  • Helix c
  • AZALOMYCIN M
  • HELIXIN C
  • ANTIBIOTIC K178
  • ANTIBIOTIC K178 SODIUM SALT
  • ANTIBIOTIC X-464
  • Polyetherin A, AzaloMycin M, Helixin C, K 178, X 464
  • Antibiotic M 2
  • x-464
  • NIGERICIN
  • NIGERICIN NA
  • NIGERICIN, NA SALT
  • NIGERICIN, SODIUM SALT, STREPTOMYCES HYGROSCOPICUS
  • POLYETHERIN A
  • Nigericin from Streptomyces hygroscopicus
  • Antibiotic K178 sodium salt, Azalomycin M
  • nigericin sodium
  • nigericin sodium from streptomyces*hygroscopicus
  • nigericin sodium salt from streptomyces hygroscopicus
  • NIGERICIN APPOX. 95%
  • 28380-24-7
  • C40H68O11
  • BioChemical
  • Antibiotics A to Z
  • Antibiotics N-S
  • Antibiotics
  • antibiotic