Therapeutic drugs for benign prostatic hyperplasia and hypertension
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Alfuzosin

Therapeutic drugs for benign prostatic hyperplasia and hypertension
Product Name
Alfuzosin
CAS No.
81403-80-7
Chemical Name
Alfuzosin
Synonyms
Afluzosin;ALFUZOSIN;ALFUZOCIN;Alfuzosion;ALFUZOSINE;Alfuzosin Impurity;Alfuzosin USP/EP/BP;Alfuzosin (SL 77499);ALFUZOSIN HYDROCLORIDE;N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)-methylamino]propyl]-2-oxolanecarboxamide
CBNumber
CB4332422
Molecular Formula
C19H27N5O4
Formula Weight
389.45
MOL File
81403-80-7.mol
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Alfuzosin Property

Melting point:
178-180 °C
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
14.80±0.20(Predicted)
color 
White to Off-White
CAS DataBase Reference
81403-80-7(CAS DataBase Reference)
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Safety

Hazardous Substances Data
81403-80-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
BA164145
Product name
Alfuzosin
Packaging
10mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA64935
Product name
Alfuzosin
Packaging
100mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-2086
Product name
Alfuzosin
Purity
99.67%
Packaging
10mg
Price
$72
Updated
2021/12/16
ApexBio Technology
Product number
B1061
Product name
Alfuzosin
Packaging
10mg
Price
$112
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA64935
Product name
Alfuzosin
Packaging
250mg
Price
$150
Updated
2021/12/16
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Alfuzosin Chemical Properties,Usage,Production

Therapeutic drugs for benign prostatic hyperplasia and hypertension

Benign prostatic hyperplasia (BPH) is a common disease in medium-elderly men. Prostatic hyperplasias obstruct urine excretion, which can cause irritant and obstructive urethral symptoms. The most common symptoms are nocturia, increased urgency during the day, frequent micturition, and urinary rheology. Many men over 70 years old have moderate or severe urethral symptoms due to BPH. Although BPH itself rarely endangers life, it can cause irreversible damage to the bladder or kidney if not treated. Acute urinary retention is the most serious complication of BPH. Its clinical features are sudden inability to urinate and pain. If not treated in time, it can endanger life. Alfuzosin is a selective alpha 1 receptor blocker, which belongs to the quinazoline derivative. By relaxing the tension of the urethra smooth muscle around the prostate, bladder neck and prostate, it can reduce the resistance of the urine flow, so that the symptoms such as urethral tension, resistance and pressure increase, bladder outlet obstruction and other symptoms related to prostatic hypertrophy can be alleviated. It has a quick effect and has little effect on the cardiovascular system, and there are no other adverse effects on sexual function like other annoying BPH drugs. The absorption of alfuzosin is good. The concentration of blood drug reaches peak 0.5-3 hours after taking, and the bioavailability is 64%. In the range of treatment dose, the pharmacokinetics is linear. About 87% of the drugs absorbed are combined with plasma protein. This product is mainly eliminated by liver metabolism.75%-91% of the inactive metabolite is excreted by the feces through the bile, and 15%-30% is excreted in the urine. Another 11% is excreted in the original form in the urine. The half-life of the elimination is 4-8 hours. Its pharmacokinetic characteristics are not affected by the meal.
In the elderly over 75 years of age, this product is absorbed faster and the concentration of the blood drug peak is higher. In addition, AUC is also higher than the young, but the volume of distribution can be reduced and the half-life will be eliminated. In renal insufficiency, it pharmacokinetic characteristics have no obvious change. In the patients with liver dysfunction, the concentration of blood drug peak, the elimination half life and the AUC value are all increased, and the free fraction is also increased. In addition, alfuzosin is similar to proposing and palavering in function. It not only blocks the alpha 1 receptor, but also smooths diastolic blood vessel muscle, so it has good antihypertensive effect. For high blood pressure, 7.5 to 10mg should be taken for 1 day 3 times daily.
It should be noticed that alfuzosin hydrochloride cannot be used with calcium antagonist and alpha blocker.

Description

Alfuzosin hydrochloride is a post-synaptic a-antagonist useful in the symptomatic treatment of benign prostatic hypertrophy and acute adenoma by lowering urethral contractions induced by alpha, stimulation. Alfuzosin is also being developed as an antihypertensive; its efficacy in this indication is comparable to prazosin with no significant change in heart rate.

Originator

Synthelabo (France)

Uses

dietary supplement

Definition

ChEBI: Alfuzosin is a monocarboxylic acid amide, a tetrahydrofuranol and a member of quinazolines. It has a role as an antineoplastic agent, an antihypertensive agent and an alpha-adrenergic antagonist.

brand name

Uroxatral (Sanofi Aventis).

General Description

Alfuzosin is also a quinazoline 1-blockerbut differs from terazosin in replacing the piperazine ring interazosin with an open piperazine ring (a rotatable propylenediaminegroup). Alfuzosin is more selective for thesubtype of α1A-receptor in the prostate gland than those invascular tissue. Thus, it has been used extensively in treatingBPH as a first-line drug with fewer cardiovascular sideeffects than terazosin and doxazosin.

Alfuzosin Preparation Products And Raw materials

Raw materials

Preparation Products

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Alfuzosin Suppliers

Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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LGM Pharma
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1-(800)-881-8210
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615-250-9817
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inquiries@lgmpharma.com
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United States
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XiaoGan ShenYuan ChemPharm co,ltd
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15527768850
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1791901229@qq.com
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China
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8843
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Hangzhou Yuhao Chemical Technology Co., Ltd
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0571-82693216
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+86-571-82880190
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info@yuhaochemical.com
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China
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9387
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Beijing Yisiyan Technology Research Center
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010-56645598 13366904824
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01062230033
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bjkaida@163.com
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China
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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waley188@sohu.com
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China
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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7552
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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021-33632979
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021-34692979
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info@tsbiochem.com
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China
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HBCChem, Inc.
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+1-510-219-6317
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+1-650-486-1361
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sales@hbcchem.com
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United States
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10648
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Finetech Industry Limited
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027-87465837 19945049750
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027-8777-2287
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sales@finetechnology-ind.com
Country
China
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9648
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View Lastest Price from Alfuzosin manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Alfuzosin 81403-80-7
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
81403-80-7 81403-80-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
81403-80-7 81403-80-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

81403-80-7, AlfuzosinRelated Search:


  • n-[3-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)methylamino]propyl]tetrahydrofuran-2-carboxamide
  • ALFUZOCIN
  • ALFUZOSIN
  • ALFUZOSIN HYDROCLORIDE
  • ALFUZOSINE
  • 2-Furancarboxamide,N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino]propyl]tetrahydro-
  • N-[3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]propyl]oxolane-2-carboxamide
  • N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)-methylamino]propyl]-2-oxolanecarboxamide
  • N-[3-[(4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl]tetrahydro-2-furancarboxamide
  • Afluzosin
  • Alfuzosion
  • (2R)-N-{3-[(4-aMino-6,7-diMethoxyquinazolin-2-yl)(Methyl)aMino]propyl}oxolane-2-carboxaMide
  • Alfuzosin (SL 77499)
  • Alfuzosin USP/EP/BP
  • AlfuzosinQ: What is Alfuzosin Q: What is the CAS Number of Alfuzosin Q: What is the storage condition of Alfuzosin Q: What are the applications of Alfuzosin
  • Alfuzosin Impurity
  • 81403-80-7
  • C19H27N5O4
  • C19H28ClN5O4
  • NUTRESTORE
  • Pharmaceutical intermediate
  • APIs
  • Adrenoceptor