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ITX-5061 HCl

Product Name
ITX-5061 HCl
CAS No.
1252679-52-9
Chemical Name
ITX-5061 HCl
Synonyms
ITX-5061;ITX506 HCl;ITX-5061 HCl;ITX-5061 hydrochloride;ITX-5061 hydrochloride (ITX5061);N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride;N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride , ITX5061
CBNumber
CB43333732
Molecular Formula
C30H38ClN3O7S
Formula Weight
620.16
MOL File
1252679-52-9.mol
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ITX-5061 HCl Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 83.3 mg/mL (134.32 mM)
form 
Solid
color 
Light yellow to light brown
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
BA1863
Product name
ITX5061
Packaging
1mg
Price
$234
Updated
2026/05/06
ApexBio Technology
Product number
BA1863
Product name
ITX5061
Packaging
5mg
Price
$468
Updated
2026/05/06
ApexBio Technology
Product number
BA1863
Product name
ITX5061
Packaging
10mg
Price
$705
Updated
2026/05/06
aablocks
Product number
AA01EOGJ
Product name
N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2026/05/30
aablocks
Product number
AA01EOGJ
Product name
N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride
Purity
98%
Packaging
5mg
Price
$119
Updated
2026/05/30
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ITX-5061 HCl Chemical Properties,Usage,Production

Uses

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

in vivo

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [3H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver[1].

References

[1] Masson D, et al. Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2054-60. DOI:10.1161/ATVBAHA.109.191320

ITX-5061 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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ITX-5061 HCl Suppliers

China 39 United States 4 Global 43
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
89686
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60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
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62
Shanghai Chaolan Chemical Technology Center
Tel
QQ：65489617 19372819560
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9627
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32466
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
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sales@hzclap.com
Country
CHINA
ProdList
6312
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Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1146
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10336
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58

1252679-52-9, ITX-5061 HClRelated Search:


  • ITX-5061 HCl
  • ITX-5061
  • ITX-5061 hydrochloride (ITX5061)
  • ITX-5061 hydrochloride
  • ITX506 HCl
  • N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride , ITX5061
  • N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride
  • 1252679-52-9