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ITX-5061 HCl

Product Name
ITX-5061 HCl
CAS No.
1252679-52-9
Chemical Name
ITX-5061 HCl
Synonyms
ITX-5061;ITX506 HCl;ITX-5061 HCl;ITX-5061 hydrochloride;ITX-5061 hydrochloride (ITX5061);N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride;N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride , ITX5061
CBNumber
CB43333732
Molecular Formula
C30H38ClN3O7S
Formula Weight
620.16
MOL File
1252679-52-9.mol
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ITX-5061 HCl Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 83.3 mg/mL (134.32 mM)
form 
Solid
color 
Light yellow to light brown
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0016951
Product name
ITX5061
Packaging
5mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0016951
Product name
ITX5061
Packaging
10mg
Price
$980
Updated
2021/12/16
ChemScene
Product number
CS-0016951
Product name
ITX5061
Packaging
50mg
Price
$3000
Updated
2021/12/16
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ITX-5061 HCl Chemical Properties,Usage,Production

Uses

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

in vivo

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [3H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver[1].

References

[1] Masson D, et al. Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2054-60. DOI:10.1161/ATVBAHA.109.191320

ITX-5061 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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ITX-5061 HCl Suppliers

China 38 United States 4 Global 42
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32435
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Aladdin Scientific
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Email
tp@aladdinsci.com
Country
United States
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52923
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BOC Sciences
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16314854226
Email
info@bocsci.com
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United States
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9923
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MedChemExpress
Tel
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Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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1252679-52-9, ITX-5061 HClRelated Search:


  • ITX-5061 HCl
  • ITX-5061
  • ITX-5061 hydrochloride (ITX5061)
  • ITX-5061 hydrochloride
  • ITX506 HCl
  • N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride , ITX5061
  • N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride
  • 1252679-52-9