(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

Product Name: (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
CAS No.: 53101-49-8
Chemical Name: (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
Synonyms: (R)-Trolox;(R)-Trolox D5;Trolox (R)-Isomer;Trolox Impurity 1 (Trolox (R)-Isomer);(R)-(+)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-C;(2R)-2,5,7,8-Tetramethyl-6-hydroxychroman-2-carboxylic acid;(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID;(R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 98%;(R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid;(R)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
CBNumber: CB4335403
Molecular Formula: C14H18O4
Formula Weight: 250.29
MOL File: 53101-49-8.mol

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(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Property

Melting point:: 162 °C (dec.) (lit.)
Boiling point:: 450.3±45.0 °C(Predicted)
Density: 1.219±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (998.84 mM)
form: Solid
pka: 3.35±0.20(Predicted)
color: White to off-white
optical activity: [α]27/D +65°, c = 1.2 in ethanol
InChI: 1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m1/s1
InChIKey: GLEVLJDDWXEYCO-CQSZACIVSA-N
SMILES: Cc1c(C)c2O[C@](C)(CCc2c(C)c1O)C(O)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 9999999999
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 391913
Product name: (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Purity: 98%
Packaging: 1g
Price: $166.51
Updated: 2025/07/31

Sigma-Aldrich

Product number: 391913
Product name: (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Purity: 98%
Packaging: 5g
Price: $538
Updated: 2025/07/31

TRC

Product number: T892565
Product name: (R)-Trolox
Packaging: 10g
Price: $925
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0003025
Product name: (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5G
Price: $1181.22
Updated: 2021/12/16

Chem-Impex

Product number: 41442
Product name: (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylicacid,97-103%(Assaybytitration)
Purity: 97-103%(Assaybytitration)
Packaging: 5G
Price: $414.4
Updated: 2021/12/16

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(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

(R)-Trolox is used in synthesis of vitamin E analogs.

General Description

(R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, a vitamin E analog, is a mushroom tyrosinase inhibitor.

(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Suppliers

China 39 Switzerland 1 United States 8 Global 48

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53101-49-8, (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACIDRelated Search:

(S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID (R)-(-)-2-HYDROXY-4-PHENYLBUTYRIC ACID 2,5-DIMETHYLPHENOXYACETIC ACID Trolox 2-Phenoxybutyric acid (R)-(+)-2-PHENOXYPROPIONIC ACID 2,6-Dimethylphenoxyacetic acid 2,3-DIMETHYLPHENOXYACETIC ACID 2,2,5,7,8-PENTAMETHYL-6-CHROMANOL 3,5-xylyloxyacetic acid Trimethylhydroquinone (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID 2-(3,5-DIMETHYLPHENOXY)-ETHANOL DUROHYDROQUINONE 2-methyl-2-(2-methylphenoxy)propanoic acid 2-(3-METHYLPHENOXY)PROPANOIC ACID Succinimidyl (2R)-6-(Tetrahydro-2H-pyran-2-yloxy)-2,5,7,8-tetramethylchroman-2-carboxylate CHROMANE-2-CARBOXYLIC ACID

(R)-(+)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-C

(2R)-2,5,7,8-Tetramethyl-6-hydroxychroman-2-carboxylic acid

(R)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

(R)-Trolox

(R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 98%

(2R)-6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

Trolox (R)-Isomer

(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2R)-

Trolox Impurity 1 (Trolox (R)-Isomer)

(R)-Trolox D5

(<i>R</i>)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

53101-49-8

Benzopyrans

Asymmetric Synthesis

Chiral Building Blocks

Heterocyclic Building Blocks

Benzopyrans

Chiral Building Blocks

Heterocyclic Building Blocks