CHROMANE-2-CARBOXYLIC ACID

Product Name: CHROMANE-2-CARBOXYLIC ACID
CAS No.: 51939-71-0
Chemical Name: CHROMANE-2-CARBOXYLIC ACID
Synonyms: IFLAB-BB F2108-0136;Nebivolol Impurity 90;2-Chromancarboxylic Acid;Chromane-2-carboxylicaci;Chroman-2-carboxylic acid;2-Chromanecarboxylic acid;CHROMANE-2-CARBOXYLIC ACID;Chroman-2-carboxylic acid 95+%;3,4-dihydro-2H-chromene-2-carboxylic acid;3,4-Dihydro-1-benzopyran-2-carboxylic acid
CBNumber: CB8776183
Molecular Formula: C10H10O3
Formula Weight: 178.18
MOL File: 51939-71-0.mol

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CHROMANE-2-CARBOXYLIC ACID Property

Melting point:: 99 °C
Boiling point:: 356.1±31.0 °C(Predicted)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 3.09±0.20(Predicted)
color: White
InChI: InChI=1S/C10H10O3/c11-10(12)9-6-5-7-3-1-2-4-8(7)13-9/h1-4,9H,5-6H2,(H,11,12)
InChIKey: SFLFCQJQOIZMHF-UHFFFAOYSA-N
SMILES: C1(C(O)=O)OC2=CC=CC=C2CC1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C427970
Product name: chromane-2-carboxylic acid
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: OR55170
Product name: Chroman-2-carboxylicacid
Purity: 95+%
Packaging: 1g
Price: $160
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H21-1-72
Product name: Chroman-2-carboxylicacid
Purity: 95.0%
Packaging: 1g
Price: $176
Updated: 2021/12/16

AK Scientific

Product number: J51715
Product name: chromane-2-carboxylic acid
Packaging: 5g
Price: $233
Updated: 2021/12/16

Matrix Scientific

Product number: 082977
Product name: Chromane-2-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $341
Updated: 2021/12/16

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CHROMANE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

Chromane-2-carboxylic Acid is used in the synthesis of 4-quinazolinones as Rho kinase inhibitors for application towards glaucoma, hypertension and spinal cord injuries. It is also used in the preparation of chromanyl-benzamidazoles as anti-bacterial compounds.

Synthesis

4940-39-0

51939-71-0

The general procedure for the synthesis of benzodihydropyran-2-carboxylic acid from 4-benzopyrone-2-carboxylic acid is as follows: Example 20: Synthesis of (±)-benzodihydropyran-2-carboxylic acid A mixture of the compound obtained in Example 19 (20.0 g, 105 mmol) and activated charcoal-loaded palladium (Pd 10%, 2.0 g) in acetic acid (200 mL) was subjected to a Parr hydrogenation unit and reacted under hydrogen pressure (60 psig). After 22.5 hours of reaction, the mixture was removed from the hydrogen atmosphere and filtered through a diatomaceous earth pad. The diatomaceous earth pad was washed with ethyl acetate (800 mL) and the filtrates were combined and concentrated to give a brown oil. The oil was dissolved in ethyl acetate (500 mL) and extracted with saturated aqueous NaHCO3 (4 x 125 mL). The aqueous phase was acidified with concentrated hydrochloric acid to pH=2 and extracted with ethyl acetate (4 x 100 mL). The organic phases were combined, washed with saturated aqueous sodium chloride solution (100 mL), dried over anhydrous magnesium sulfate and concentrated to give a colorless solid product (18.0 g, 96% yield). The melting point of the product was 97.5-99 °C; 1H NMR (DMSO-d6, 300 MHz) δ 12.96 (br s, 1H), 7.03 (m, 2H), 6.78 (m, 2H), 4.74 (dd, J = 6.4 Hz, 3.9 Hz, 1H), 2.73 (m, 1H), 2.63 (m, 1H), 2.03 (m, 2H ).

References

[1] Patent: EP1054881, 2008, B1. Location in patent: Page/Page column 31
[2] Patent: US6469031, 2002, B1
[3] Patent: WO2013/124828, 2013, A1. Location in patent: Page/Page column 48
[4] Patent: US2015/38546, 2015, A1. Location in patent: Paragraph 0355-0356
[5] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0071

CHROMANE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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CHROMANE-2-CARBOXYLIC ACID Suppliers

Belgium 1 Canada 2 China 80 Germany 2 India 3 United Kingdom 3 United States 11 Global 102

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Hangzhou Sage Chemical Co., Ltd.

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Thermo Fisher Scientific

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Baiyin Chengze Chemical Technology Co., Ltd.

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View Lastest Price from CHROMANE-2-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: CHROMANE-2-CARBOXYLIC ACID 51939-71-0
Price: US $1.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-10

51939-71-0, CHROMANE-2-CARBOXYLIC ACIDRelated Search:

CHROMONE 3,4-Dihydro-(1H)-benzopyrane Tryptamine Chroman-8-carbaldehyde, 95% chroman-5-carboxylic acid 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid Trolox ablukast 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 3,4-DIHYDRO-6-HYDROXY- CHROMANE-2-CARBOXYLIC ACID (S)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID CPCCOET 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-BROMO-3,4-DIHYDRO- (R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID (S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 3,4-DIHYDRO-6-METHOXY- XANTHOQUINODIN A1

CHROMANE-2-CARBOXYLIC ACID

IFLAB-BB F2108-0136

2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 3,4-DIHYDRO-

Chroman-2-carboxylic acid

3,4-Dihydro-2H-1-benzopyran-2-carboxylic acid

3,4-Dihydro-1-benzopyran-2-carboxylic acid

Chroman-2-carboxylic acid 95+%

Nebivolol Impurity 90

2-Chromancarboxylic Acid

3,4-dihydro-2H-chromene-2-carboxylic acid

Chromane-2-carboxylicaci

2-Chromanecarboxylic acid

51939-71-0

Heterocycles series

Carboxylic Acids

Fused Ring Systems