Simmitecan Hydrochloride

Product Name: Simmitecan Hydrochloride
CAS No.: 1247847-78-4
Chemical Name: Simmitecan Hydrochloride
Synonyms: Simmitecan Hydrochloride
CBNumber: CB43358869
Molecular Formula: C34H39ClN4O6
Formula Weight: 635.14966
MOL File: 1247847-78-4.mol

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Hazard and Precautionary Statements (GHS)

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Simmitecan Hydrochloride Chemical Properties,Usage,Production

Uses

Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].

in vivo

Simmitecan hydrochloride (3.75, 7.5 and 15 mg/kg, i.v. bolus) shows mean elimination half-life t_1/2 of approximately 1.4 h in SD rats^[2].

References

[1] Rini B, et al. A phase I/II study of lenalidomide in combination with sunitinib in patients with advanced or metastatic renal cell carcinoma. Ann Oncol. 2014 Sep;25(9):1794-1799. DOI:10.1093/annonc/mdu212
[2] Hu ZY, et al. Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals. Acta Pharmacol Sin. 2013 Nov;34(11):1437-48. DOI:10.1038/aps.2013.74

Simmitecan Hydrochloride Preparation Products And Raw materials

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Preparation Products

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Simmitecan Hydrochloride Suppliers

China 7 United States 1 Global 8

Shanghai Zhen Li Biological Technology Co., Ltd

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Shochem(Shanghai)Co.,Ltd

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TargetMol Chemicals Inc.

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Shochem(Shanghai) Co.,Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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TargetMol Chemicals Inc.

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Sangon Biotech (Shanghai) Co.,Ltd.

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Biosynth Biological Technology (Suzhou) Co Ltd

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Simmitecan Hydrochloride

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