ChemicalBook > CAS DataBase List > Simmitecan Hydrochloride
Simmitecan Hydrochloride
- Product Name
- Simmitecan Hydrochloride
- CAS No.
- 1247847-78-4
- Chemical Name
- Simmitecan Hydrochloride
- Synonyms
- Simmitecan Hydrochloride
- CBNumber
- CB43358869
- Molecular Formula
- C34H39ClN4O6
- Formula Weight
- 635.14966
- MOL File
- 1247847-78-4.mol
More
Less
Simmitecan Hydrochloride Chemical Properties,Usage,Production
Uses
Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].
in vivo
Simmitecan hydrochloride (3.75, 7.5 and 15 mg/kg, i.v. bolus) shows mean elimination half-life t1/2 of approximately 1.4 h in SD rats[2].
References
[1] Rini B, et al. A phase I/II study of lenalidomide in combination with sunitinib in patients with advanced or metastatic renal cell carcinoma. Ann Oncol. 2014 Sep;25(9):1794-1799. DOI:10.1093/annonc/mdu212
[2] Hu ZY, et al. Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals. Acta Pharmacol Sin. 2013 Nov;34(11):1437-48. DOI:10.1038/aps.2013.74
Simmitecan Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Simmitecan Hydrochloride Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58