4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

ChemicalBook > CAS DataBase List > 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

Product Name: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
CAS No.: 864725-62-2
Chemical Name: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
Synonyms: 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid;Fluralaner-024;Fluralaner Impurity 3;Fluralaner Impurity 2;Fluralaner Impurity 6;Fluralaner N-1 intermediate;Intermediate of FluralanerⅢ;Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19;4-[5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-isoxazolyl]-2-methylbenzoic Acid;Benzoic acid, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-
CBNumber: CB43364743
Molecular Formula: C18H12Cl2F3NO3
Formula Weight: 418.19
MOL File: 864725-62-2.mol

Less

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Property

Boiling point:: 511.3±60.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: 2-8°C Refrigerator
pka: 3.61±0.25(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Less

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Chemical Properties,Usage,Production

Uses

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is an organic intermediate compound used in the synthesis of Fluralaner.

Synthesis

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is prepared by the reaction of 2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid and 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole. The steps are as follows:
In a 100 mL three-necked flask, under nitrogen protection, add 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (700 mg, 1.93 mmoL), 2-methyl-4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)benzoic acid (560 mg, 2.14 mmoL), potassium acetate (379 mg, 3.86mmol), 1,4-dioxane (15mL), water (1.5mL) and Pd(dppf)Cl2 (141mg, 0.19mmol), incubate the reaction at 85±5 for 8h, stop heating to room temperature, then Water (50 mL) was added to quench and then extracted with dichloromethane (45 mL×2), the organic phases were combined, the organic phase was washed once with saturated brine (50 mL), and then the organic phase was washed with anhydrous sodium sulfate (10.0 g). ) was dried for 2 h, the organic phase was concentrated to dryness under reduced pressure, and the concentrated residue was purified by silica gel column chromatography (developing solvent: n-heptane/ethyl acetate=10:1-3:1) to obtain 4-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid (694 mg, 86%) as a pale yellow solid.

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Suppliers

China 74 India 1 Global 75

Madision Biomedical Co., Ltd.

Tel: 028-87439248 19150327610
Fax: 028-87439248
Email: 553691721@qq.com
Country: China
ProdList: 62
Advantage: 58

Jinan Hongda Trading Co., Ltd.

Tel: 182-6550-6873 18265506873
Email: 439706954@qq.com
Country: China
ProdList: 128
Advantage: 58

Naphthalene Strontium Chemical Technology (Changzhou) Co., Ltd

Tel: 13382843997 13382843997
Email: 420765640@qq.com
Country: China
ProdList: 26
Advantage: 58

Henan Dongyao Pharmaceutical Technology Co., Ltd

Tel: 18519331287
Email: 1751713684@qq.com
Country: China
ProdList: 172
Advantage: 58

Jinan Chenghui Shuangda biological Co., LTD

Tel: 0531-58897003 15550412551
Fax: 0531-58897003
Email: market@jnchsd.com
Country: China
ProdList: 217
Advantage: 62

Changzhou Yuanhe Biopharmaceutical Co., Ltd

Tel: 15995091686
Email: 15995091686@163.com
Country: China
ProdList: 40
Advantage: 58

Jinan Hongkangda Chemical Co., Ltd

Tel: 0531-0531-88901705 18753193522
Email: 810353473@qq.com
Country: China
ProdList: 138
Advantage: 58

Jinan Yunding Biotechnology Co., Ltd

Tel: 15662712965
Email: 1013429786@qq.com
Country: China
ProdList: 22
Advantage: 58

HuiFeiChem(WuXi) PharmaTech Co.,Ltd

Tel: 0510-0510-83593305
Fax: 0086-510-83593305
Email: sales@huifeichem.com
Country: China
ProdList: 104
Advantage: 62

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 679
Advantage: 62

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 15343847665
Fax: QQ：3470079902
Email: huawenchem@163.com
Country: China
ProdList: 3205
Advantage: 55

Junyu Chemexpress Co., Ltd.

Tel: 0731-88036271 13723890100
Fax: 0731-88036271
Email: info@csjyyy.com
Country: China
ProdList: 47
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17994
Advantage: 56

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9911
Advantage: 50

Zhengzhou Alfachem Co.,Ltd.

Tel: 0371-53778726 18003825608
Fax: QQ：2885354392
Email: liuxiaoyan@alfachem.cn
Country: China
ProdList: 1951
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Zhixin Chemical Technology Co., Ltd.

Tel: 021-60441077 18701958033
Fax: 021-60441077
Email: shzxchem@163.com
Country: China
ProdList: 563
Advantage: 58

Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd

Tel: +86-021-50929289 +86-18721298335
Fax: -
Email: sales@ypptech.com.cn
Country: China
ProdList: 344
Advantage: 58

CHENGHUI PHARMACEUTICAL GROUP LTD

Tel: 0531-58897070 15254140813
Fax: 0531-58897046
Email: market@jnchsd.com
Country: China
ProdList: 216
Advantage: 58

Shandong Chenxi Pharmaceutical Co., Ltd.

Tel: +86-0531-88803416 13153166250
Fax: 0531-88803416
Email: sales@chemedpharma.com
Country: China
ProdList: 248
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 9944
Advantage: 58

Jinan Guoding Pharmaceutical Technology Co., Ltd.

Tel: 15665775653
Fax: 053167801621
Email: sales@guodingpharma.com
Country: China
ProdList: 480
Advantage: 58

Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.

Tel: 0531-58897130 15508676053
Email: drug_impurity@sdcclh.com
Country: China
ProdList: 1825
Advantage: 58

Hunan chemfish Scientific co.,ltd

Tel: +8619313119731 15528049369
Email: sales@chemfish.com
Country: China
ProdList: 4913
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 13021512891
Fax: QQ:3554193828
Email: sales02@chemfish.com
Country: China
ProdList: 6622
Advantage: 58

Wuhan Ruilida Biomedical Technology Co., Ltd.

Tel: 18201884268
Email: magean83@163.com
Country: China
ProdList: 1240
Advantage: 58

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14253
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: 021-58955996
Email: info@chemexpress.com
Country: China
ProdList: 695
Advantage: 58

wuhan dingxingtong Chemical Technology Co., Ltd Co., Ltd

Tel: 027-59207796 13429867250
Fax: 027-59207796
Email: w13429867250@163.com
Country: China
ProdList: 1997
Advantage: 58

SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

Tel: 0755-0755-0755-83725350 13380397412
Fax: 0755-28094224
Email: 3001280422@qq.com
Country: China
ProdList: 9956
Advantage: 58

Atomic chemistry

Tel: 0370-2785705 19339619972
Fax: QQ：3564171929
Email: 2234585634@qq.com
Country: China
ProdList: 4175
Advantage: 58

Hubei Zhongshan Medical Technology Co., Ltd

Tel: 027-61907345 13397111514
Fax: 3443707954
Email: w13397111514@163.com
Country: China
ProdList: 1011
Advantage: 58

Jinan Chenghuishuangda Chemical Co., Ltd

Tel: 0531-58897087 18953117380
Fax: QQ：1573212988
Email: 1135136112@qq.com
Country: China
ProdList: 60
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 39997
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: 13670046396
Email: ORDERS@QCSRM.COM
Country: China
ProdList: 18820
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7977
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6637
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 61720
Advantage: 58

Qingzhou dafeng import and export Co. LTD

Tel: 16773308882
Email: 927608786@qq.com
Country: China
ProdList: 3051
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9892
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 13339985473
Email: C13339985473@163.com
Country: China
ProdList: 3455
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7696
Advantage: 58

Jiangsu Boquan Biotechnology Co., Ltd.

Tel: 15252131412
Email: 5954981@qq.com
Country: China
ProdList: 2964
Advantage: 58

Shaanxi Dideu Newmaterial Co., Ltd.

Tel: 029-63373950 15353716720
Email: 1052@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 2780
Advantage: 58

Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd

Tel: 18072846723
Email: caigou1@witofly.com
Country: China
ProdList: 18926
Advantage: 58

Beijing ECom Technology Co., Ltd.

Tel: 17710328343
Email: 3004011422@qq.com
Country: China
ProdList: 1955
Advantage: 58

Hepharma Biology And Technology CO.,LTD.

Tel: 181-55150309 18155150309
Email: waimaobu@hepharma.cn
Country: China
ProdList: 2896
Advantage: 58

Entrenture (Lanzhou) Biomedical Technology Co., Ltd

Tel: 13919408782; 13919408782
Email: 1297709337@qq.com
Country: China
ProdList: 104
Advantage: 58

Hubei Chenghai Chemical Co., Ltd

Tel: 18327245847 18327245847
Email: 1400838877@qq.com
Country: China
ProdList: 9992
Advantage: 58

Less

View Lastest Price from 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid manufacturers

PNP Biotech Co. Ltd

Product: 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid 864725-62-2
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-10-21

Hebei Xinsheng New Material Technology Co., LTD.

Product: 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid 864725-62-2
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 30000 KG
Release date: 2023-10-13

Henan Aochuang Chemical Co.,Ltd.

Product: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid 864725-62-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

864725-62-2, 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acidRelated Search:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride Fluralaner Impurity 5 3-(4-bromo-3-methylphenyl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole Fluralaner Impurity 4 Fluralaner 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid

Fluralaner Impurity 2

Fluralaner Impurity 3

Fluralaner-024

Fluralaner Impurity 6

Fluralaner N-1 intermediate

Benzoic acid, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-

4-[5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-isoxazolyl]-2-methylbenzoic Acid

Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19

Intermediate of FluralanerⅢ

864725-62-2

API