3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
- Product Name
- 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
- CAS No.
- 130336-16-2
- Chemical Name
- 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
- Synonyms
- 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethan-1-one;1-(3,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE;uoroethanone;1-(3,5-DichL;5-DICHLORO-2;)-2,2,2-trifL;Fluralaner-002;Acetophenone673;Fluralaner Impurity 28;2-TRIFLUOROACETOPHENONE
- CBNumber
- CB0206550
- Molecular Formula
- C8H3Cl2F3O
- Formula Weight
- 243.01
- MOL File
- 130336-16-2.mol
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Property
- Boiling point:
- 265℃
- Density
- 1.506
- refractive index
- 1.4980 to 1.5020
- Flash point:
- 114℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Colourless
- InChI
- InChI=1S/C8H3Cl2F3O/c9-5-1-4(2-6(10)3-5)7(14)8(11,12)13/h1-3H
- InChIKey
- DZDSQRPDUCSOQV-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC(Cl)=CC(Cl)=C1)C(F)(F)F
- CAS DataBase Reference
- 130336-16-2
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D5113
- Product name
- 3',5'-Dichloro-2,2,2-trifluoroacetophenone
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- D5113
- Product name
- 3',5'-Dichloro-2,2,2-trifluoroacetophenone
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $169
- Updated
- 2025/07/31
- Product number
- D436405
- Product name
- 3'',5''-Dichloro-2,2,2-trifluoroacetophenone
- Packaging
- 25g
- Price
- $730
- Updated
- 2021/12/16
- Product number
- HCH0012118
- Product name
- 3',5'-DICHLORO-2,2,2-TRIFLUORO ACETOPHENONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $818.61
- Updated
- 2021/12/16
- Product number
- 6518-2
- Product name
- 3',5'-Dichloro-2,2,2-trifluoroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $1059
- Updated
- 2021/12/16
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Chemical Properties,Usage,Production
Uses
3'',5''-Dichloro-2,2,2-trifluoroacetophenone is a reagent used for enantioselective preparation of benzazephinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids
Synthesis
19752-55-7
407-25-0
130336-16-2
Under nitrogen protection, tert-butyllithium (1.3 M in pentane, 17.8 mL, 23.2 mmol) was slowly added dropwise to a solution of 3,5-dichloro-1-bromobenzene (5.0 g, 22.1 mmol) in tetrahydrofuran (50 mL) over a period of 30 min, followed by continuing the reaction for 2 h at -78 °C. Upon completion of the reaction, trifluoroacetic anhydride (2.56 g, 12.2 mmol) was slowly added dropwise to the reaction mixture and stirring was continued for 2 hours at -78 °C. The cooling bath was removed and the reaction mixture was allowed to warm slowly to room temperature and stirring was continued at room temperature for 2.5 hours. When the reaction was terminated, saturated ammonium chloride solution (50 mL) was added. The reaction mixture was extracted with ether (3 x 50 mL) and the organic phases were combined and washed with saturated brine (20 mL x 2). The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure, and purified by distillation under reduced pressure to give the colorless transparent liquid 3',5'-dichloro-2,2,2-trifluoroacetophenone (2.58 g, 48% yield).
References
[1] Patent: CN107353189, 2017, A. Location in patent: Paragraph 0019; 0023
[2] Bulletin of the Chemical Society of Japan, 1997, vol. 70, # 12, p. 3081 - 3090
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE manufacturers
- Product
- 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone 130336-16-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 130336-16-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-07
- Product
- 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 130336-16-2
- Price
- US $3320.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1T
- Release date
- 2020-07-06