ChemicalBook > CAS DataBase List > 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

Product Name: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
CAS No.: 130336-16-2
Chemical Name: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
Synonyms: 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethan-1-one;1-(3,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE;uoroethanone;1-(3,5-DichL;5-DICHLORO-2;)-2,2,2-trifL;Fluralaner-002;Acetophenone673;Fluralaner Impurity 28;2-TRIFLUOROACETOPHENONE
CBNumber: CB0206550
Molecular Formula: C8H3Cl2F3O
Formula Weight: 243.01
MOL File: 130336-16-2.mol

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3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Property

Boiling point:: 265℃
Density: 1.506
refractive index: 1.4980 to 1.5020
Flash point:: 114℃
storage temp.: Sealed in dry,Room Temperature
solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Oil
color: Colourless
InChI: InChI=1S/C8H3Cl2F3O/c9-5-1-4(2-6(10)3-5)7(14)8(11,12)13/h1-3H
InChIKey: DZDSQRPDUCSOQV-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(Cl)=CC(Cl)=C1)C(F)(F)F
CAS DataBase Reference: 130336-16-2

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5113
Product name: 3',5'-Dichloro-2,2,2-trifluoroacetophenone
Purity: >96.0%(GC)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: D5113
Product name: 3',5'-Dichloro-2,2,2-trifluoroacetophenone
Purity: >96.0%(GC)
Packaging: 5g
Price: $169
Updated: 2025/07/31

TRC

Product number: D436405
Product name: 3'',5''-Dichloro-2,2,2-trifluoroacetophenone
Packaging: 25g
Price: $730
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0012118
Product name: 3',5'-DICHLORO-2,2,2-TRIFLUORO ACETOPHENONE
Purity: 95.00%
Packaging: 1G
Price: $818.61
Updated: 2021/12/16

Rieke Metals

Product number: 6518-2
Product name: 3',5'-Dichloro-2,2,2-trifluoroacetophenone
Purity: 97%
Packaging: 5g
Price: $1059
Updated: 2021/12/16

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3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Uses

3'',5''-Dichloro-2,2,2-trifluoroacetophenone is a reagent used for enantioselective preparation of benzazephinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

Synthesis

19752-55-7

407-25-0

130336-16-2

Under nitrogen protection, tert-butyllithium (1.3 M in pentane, 17.8 mL, 23.2 mmol) was slowly added dropwise to a solution of 3,5-dichloro-1-bromobenzene (5.0 g, 22.1 mmol) in tetrahydrofuran (50 mL) over a period of 30 min, followed by continuing the reaction for 2 h at -78 °C. Upon completion of the reaction, trifluoroacetic anhydride (2.56 g, 12.2 mmol) was slowly added dropwise to the reaction mixture and stirring was continued for 2 hours at -78 °C. The cooling bath was removed and the reaction mixture was allowed to warm slowly to room temperature and stirring was continued at room temperature for 2.5 hours. When the reaction was terminated, saturated ammonium chloride solution (50 mL) was added. The reaction mixture was extracted with ether (3 x 50 mL) and the organic phases were combined and washed with saturated brine (20 mL x 2). The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure, and purified by distillation under reduced pressure to give the colorless transparent liquid 3',5'-dichloro-2,2,2-trifluoroacetophenone (2.58 g, 48% yield).

References

[1] Patent: CN107353189, 2017, A. Location in patent: Paragraph 0019; 0023
[2] Bulletin of the Chemical Society of Japan, 1997, vol. 70, # 12, p. 3081 - 3090

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone 130336-16-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

airuikechemical co., ltd.

Product: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 130336-16-2
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-07

Shaanxi Dideu Medichem Co. Ltd

Product: 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 130336-16-2
Price: US $3320.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1T
Release date: 2020-07-06

130336-16-2, 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONERelated Search:

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Fluralaner Impurity 4 Fluralaner Malononitrile Lithium trifluoromethanesulfonate Copper(II) chloride dihydrate SODIUM METHACRYLATE Copper(II) sulfate pentahydrate Benzoyl chloride Chalcone Dichloroethane 2',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 2',4'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 2,6-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 2',3'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 3',4'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 3'-CHLORO-2,2,2-TRIFLUOROACETOPHENONE 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

1-(3,5-DICHLORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE

1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-ethanone

1-(3,5-dichlorophenyl)-2,2,2-trifluoroethan-1-one

1-(3,5-DichL

uoroethanone

Ethanone, 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-

)-2,2,2-trifL

3',5'-Dichloro-2,2,2-trifluoroacetophenone （Fluralaner intermediate）

Fluralaner-002

2-TRIFLUOROACETOPHENONE

5-DICHLORO-2

2,2,2-Trifluoro-1-(3,5-dichlorophenyl)ethanone, 96%

3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE 130336-16-2

3',5' dichloro trifluoro acetophenone

3,5-Dichloro-2,2,2-trifluorophenone

3',5'-Dichloro-2,2,2-trifluoroacetophenone （Fluralaner intermediate）

Fluralaner Impurity 28

N - [[2- [[[4- (aminoiminomethyl) phenyl] amino] methyl] -1-methyl-1H-benzimidazol-5-yl] carbonyl] - N-2-pyridine-BETA-alanine ethyl ester

3,5-Dichloro-2',2',2'-trifluoroacetophenone

1-(3,5-Dichlorophenyl)-2,2,2-trifluorobenzophenone

3',5'-Dichloro-2,2,2-trifluorobenzophenone

3′,5′-Dichloro-2,2,2-trifluoroacetophenone, CAS 130336-16-2

3 ', 5' - Dichloro-2,2,2-trifluoroacetophenone (intermediate of Frellana)

1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-ethanonChemicalbooke

1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone 98%

Acetophenone673

130336-16-2

30336-16-2

1300336-16-2

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