ChemicalBook > CAS DataBase List > 2,4-Difluoro-3-iodoaniline

2,4-Difluoro-3-iodoaniline

Product Name: 2,4-Difluoro-3-iodoaniline
CAS No.: 1437316-91-0
Chemical Name: 2,4-Difluoro-3-iodoaniline
Synonyms: HE-CHEMICAL 0400806;2,4-Difluoro-3-iodoaniline;2, 6-dichloro-3-bromoaniline;Benzenamine, 2,4-difluoro-3-iodo-;2,4-difluoro-3-iodoaniline - [AC77843]
CBNumber: CB43367577
Molecular Formula: C6H4F2IN
Formula Weight: 255
MOL File: 1437316-91-0.mol

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2,4-Difluoro-3-iodoaniline Property

Boiling point:: 266.7±40.0 °C(Predicted)
Density: 2.086±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
pka: 2.30±0.10(Predicted)
Appearance: Off-white to light brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D451708
Product name: 2,4-Difluoro-3-iodoaniline
Packaging: 1g
Price: $340
Updated: 2021/12/16

AK Scientific

Product number: 1804EB
Product name: 2,4-Difluoro-3-iodoaniline
Packaging: 1g
Price: $870
Updated: 2021/12/16

Ark Pharm

Product number: AK362272
Product name: 2,4-Difluoro-3-iodoaniline
Purity: 97%
Packaging: 1g
Price: $91
Updated: 2021/12/16

Ambeed

Product number: A337360
Product name: 2,4-Difluoro-3-iodoaniline
Purity: 97%
Packaging: 5g
Price: $273
Updated: 2021/12/16

Ambeed

Product number: A337360
Product name: 2,4-Difluoro-3-iodoaniline
Purity: 97%
Packaging: 250mg
Price: $35
Updated: 2021/12/16

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2,4-Difluoro-3-iodoaniline Chemical Properties,Usage,Production

Uses

2,?4-?Difluoro-?3-?iodoaniline is used in the synthetic preparation of purine derivatives that are protein kinase modulators useful in treatment and prevention of protein kinase-mediated diseases.

Synthesis

1145881-54-4

1437316-91-0

General procedure for the synthesis of 2,4-difluoro-3-iodoaniline from 1,3-difluoro-2-iodo-4-nitrobenzene: To a solution of concentrated hydrochloric acid (4 mL) of 1,3-difluoro-2-iodo-4-nitrobenzene (1.14 g, 4 mmol) was added anhydrous stannous chloride (2.71 g, 12 mmol), and the reaction mixture was heated to 50°C and kept for 1 hour. After completion of the reaction, the mixture was diluted with water, neutralized with 5% aqueous sodium hydroxide solution to pH=9, and then extracted with dichloromethane. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2,4-difluoro-3-iodoaniline (0.93 g, 91% yield).1H NMR (CDCl3): δ 6.70-6.93 (2H, m), 6.65 (2H, br).

References

[1] Patent: WO2013/71865, 2013, A1. Location in patent: Page/Page column 57
[2] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0501-0503

2,4-Difluoro-3-iodoaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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1437316-91-0, 2,4-Difluoro-3-iodoanilineRelated Search:

2,4-Difluoro-3-iodoaniline

Benzenamine, 2,4-difluoro-3-iodo-

HE-CHEMICAL 0400806

2,4-difluoro-3-iodoaniline - [AC77843]

2, 6-dichloro-3-bromoaniline

1437316-91-0