1A-116

Product Name: 1A-116
CAS No.: 1430208-73-3
Chemical Name: 1A-116
Synonyms: 1A-116;1A-116, 10 mM in DMSO;1A-116; 1A 116; 1A116;1430208-73-3;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine;N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine;Guanidine, N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine , 1A-116;TIAM1,inhibit,1A 116,Ras,Rho GTPases,EGF,Apoptosis,1A-116,circadian rhythms,1A116,Inhibitor
CBNumber: CB43386440
Molecular Formula: C16H16F3N3
Formula Weight: 307.31
MOL File: 1430208-73-3.mol

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1A-116 Property

Boiling point:: 357.5±52.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (325.40 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 9.78±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A965343
Product name: 1A-116
Packaging: 5mg
Price: $440
Updated: 2021/12/16

ChemScene

Product number: CS-8141
Product name: 1A-116
Purity: 99.39%
Packaging: 25mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-8141
Product name: 1A-116
Purity: 99.39%
Packaging: 5mg
Price: $192
Updated: 2021/12/16

ChemScene

Product number: CS-8141
Product name: 1A-116
Purity: 99.39%
Packaging: 10mg
Price: $312
Updated: 2021/12/16

ChemScene

Product number: CS-8141
Product name: 1A-116
Purity: 99.39%
Packaging: 50mg
Price: $1128
Updated: 2021/12/16

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1A-116 Chemical Properties,Usage,Production

Uses

A1-116 is a novel specific Rac1 inhibitor.

in vivo

1A-116 (3 mg/kg; i.v.; once a day for 21 days) demonstrates a high antimetastatic activity with about 60% formation reduction of total metastatic lung colonies in vivo and shows no apparent toxicity^[1].
? 1A-116 (20 mg/kg; i.p.; once a day, 73 days for ZT12, 68 days for ZT3) increases survival time when treated at ZT12 compare to ZT3 in tumor-bearing mice. (ZT: Zeitgeber time 12 (ZT12) defined as the time of lights off (local time 7 p.m.) and ZT0 defined as lights on (local time 7 a.m.))^[2].
? 1A-116 shows good oral availability^[3].

Animal Model:	Female BALB/c inbred mice (8 to 10-week-old; average 20 g)^[1]
Dosage:	3 mg/kg
Administration:	Intravenous injection; once a day for 21 days.
Result:	Demonstrated a high antimetastatic activity.

Animal Model:	Male NIH Swiss foxN1(?/?) nude mice (2-month-old; GBM model)^[2].
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection (at ZT3, ZT12); once a day, 73 days for ZT12, 68 days for ZT3.
Result:	Increased survival time when treated at ZT12 compared to ZT3 in tumor-bearing mice.

storage

Store at -20°C

1A-116 Preparation Products And Raw materials

Raw materials

Preparation Products

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1A-116 Suppliers

China 41 United States 3 Global 44

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
Advantage: 58

1430208-73-3, 1A-116Related Search:

1A-116

1A-116; 1A 116; 1A116;1430208-73-3

Guanidine, N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-

TIAM1,inhibit,1A 116,Ras,Rho GTPases,EGF,Apoptosis,1A-116,circadian rhythms,1A116,Inhibitor

1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine , 1A-116

1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine

1A-116, 10 mM in DMSO

N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine

1430208-73-3

C16H16F3N3

API