1A-116
- Product Name
- 1A-116
- CAS No.
- 1430208-73-3
- Chemical Name
- 1A-116
- Synonyms
- 1A-116;1A-116, 10 mM in DMSO;1A-116; 1A 116; 1A116;1430208-73-3;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine;N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine;Guanidine, N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine , 1A-116;TIAM1,inhibit,1A 116,Ras,Rho GTPases,EGF,Apoptosis,1A-116,circadian rhythms,1A116,Inhibitor
- CBNumber
- CB43386440
- Molecular Formula
- C16H16F3N3
- Formula Weight
- 307.31
- MOL File
- 1430208-73-3.mol
1A-116 Property
- Boiling point:
- 357.5±52.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (325.40 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 9.78±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A965343
- Product name
- 1A-116
- Packaging
- 5mg
- Price
- $440
- Updated
- 2021/12/16
- Product number
- CS-8141
- Product name
- 1A-116
- Purity
- 99.39%
- Packaging
- 5mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- CS-8141
- Product name
- 1A-116
- Purity
- 99.39%
- Packaging
- 10mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- CS-8141
- Product name
- 1A-116
- Purity
- 99.39%
- Packaging
- 25mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CS-8141
- Product name
- 1A-116
- Purity
- 99.39%
- Packaging
- 50mg
- Price
- $1128
- Updated
- 2021/12/16
1A-116 Chemical Properties,Usage,Production
Uses
A1-116 is a novel specific Rac1 inhibitor.
in vivo
1A-116 (3 mg/kg; i.v.; once a day for 21 days) demonstrates a high antimetastatic activity with about 60% formation reduction of total metastatic lung colonies in vivo and shows no apparent toxicity[1].
?
1A-116 (20 mg/kg; i.p.; once a day, 73 days for ZT12, 68 days for ZT3) increases survival time when treated at ZT12 compare to ZT3 in tumor-bearing mice. (ZT: Zeitgeber time 12 (ZT12) defined as the time of lights off (local time 7 p.m.) and ZT0 defined as lights on (local time 7 a.m.))[2].
?
1A-116 shows good oral availability[3].
| Animal Model: | Female BALB/c inbred mice (8 to 10-week-old; average 20 g)[1] |
| Dosage: | 3 mg/kg |
| Administration: | Intravenous injection; once a day for 21 days. |
| Result: | Demonstrated a high antimetastatic activity. |
| Animal Model: | Male NIH Swiss foxN1(?/?) nude mice (2-month-old; GBM model)[2]. |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection (at ZT3, ZT12); once a day, 73 days for ZT12, 68 days for ZT3. |
| Result: | Increased survival time when treated at ZT12 compared to ZT3 in tumor-bearing mice. |
storage
Store at -20°C
1A-116 Preparation Products And Raw materials
Raw materials
Preparation Products
1A-116 Suppliers
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
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- 32435
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- +1-781-999-5354;
- support@targetmol.com
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- United States
- ProdList
- 39035
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- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58