5-FLUOROBENZO[D]OXAZOLE-2-THIOL
- Product Name
- 5-FLUOROBENZO[D]OXAZOLE-2-THIOL
- CAS No.
- 13451-78-0
- Chemical Name
- 5-FLUOROBENZO[D]OXAZOLE-2-THIOL
- Synonyms
- 5-Fluorobenzoxazole-2-thiol;2-Mercapto-5-fluorobenzoxazole;5-Fluorobenzoxazole-2-thiol 97%;5-FLUOROBENZO[D]OXAZOLE-2-THIOL;5-Fluoro-2(3H)-benzoxazolethiene;5-Fluorobenzoxazole-2(3H)-thione;5-Fluorobenzoxazole-2-thiol, 97%,;2(3H)-Benzoxazolethione, 5-fluoro-;5-
Fluorobenzoxazole- 2- thiol;JR-8607, 5-Fluorobenzo[d]oxazole-2-thiol, 97% - CBNumber
- CB4341448
- Molecular Formula
- C7H4FNOS
- Formula Weight
- 169.18
- MOL File
- 13451-78-0.mol
5-FLUOROBENZO[D]OXAZOLE-2-THIOL Property
- Melting point:
- 238-240℃
- Boiling point:
- 238.8±42.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder
- pka
- 10.10±0.20(Predicted)
- Appearance
- Off-white to pink Solid
- Sensitive
- Moisture & Light Sensitive
- CAS DataBase Reference
- 13451-78-0
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-41
- Safety Statements
- 26-39-24/25
- WGK Germany
- 3
- HS Code
- 29349990
N-Bromosuccinimide Price
- Product number
- 699969
- Product name
- 5-Fluorobenzoxazole-2-thiol
- Purity
- 97%
- Packaging
- 1g
- Price
- $72.1
- Updated
- 2023/06/20
- Product number
- F596108
- Product name
- 5-Fluoro-3H-1,3-benzoxazole-2-thione
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W005135
- Product name
- 5-Fluorobenzo[d]oxazole-2-thiol
- Purity
- >98.0%
- Packaging
- 5g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- PC904486
- Product name
- 5-Fluorobenzo[d]oxazole-2-thiol
- Purity
- 98%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 098370
- Product name
- 5-Fluorobenzo[d]oxazole-2-thiol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
5-FLUOROBENZO[D]OXAZOLE-2-THIOL Chemical Properties,Usage,Production
Synthesis
75-15-0
399-97-3
13451-78-0
2-Amino-4-fluorophenol (10 g, 78.8 mmol), carbon disulfide (35 mL) and potassium hydroxide (5.3 g, 94.6 mmol) were mixed in ethanol (200 mL) and heated to reflux the reaction overnight. Upon completion of the reaction, the reaction mixture was concentrated to dryness and subsequently diluted with water. The diluted solution was neutralized with 1 M hydrochloric acid solution and then extracted several times with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and finally concentrated under vacuum to give 5-fluorobenzo[d]oxazole-2-thiol 9.3 g in 70% yield. The product was identified by 1H NMR (300MHz, DMSO-d6): δ7.51 (ddd, J=8.8,4.2,0.6Hz, 1H), 7.15-7.04 (m, 2H), 3.31 (brs, 1H). lC-MS (m/z): 170.2.
References
[1] Patent: WO2017/23941, 2017, A1. Location in patent: Page/Page column 50; 51
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 913 - 923
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 16, p. 3015 - 3021
[4] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 10, p. 3515 - 3523
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
5-FLUOROBENZO[D]OXAZOLE-2-THIOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-FLUOROBENZO[D]OXAZOLE-2-THIOL manufacturers
- Product
- 5-Fluorobenzo[d]oxazole-2-thiol 13451-78-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 5-FLUOROBENZO[D]OXAZOLE-2-THIOL 13451-78-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-02-20