ChemicalBook > CAS DataBase List > 5-FLUOROBENZO[D]OXAZOLE-2-THIOL

5-FLUOROBENZO[D]OXAZOLE-2-THIOL

Product Name: 5-FLUOROBENZO[D]OXAZOLE-2-THIOL
CAS No.: 13451-78-0
Chemical Name: 5-FLUOROBENZO[D]OXAZOLE-2-THIOL
Synonyms: 5-Fluorobenzoxazole-2-thiol;2-Mercapto-5-fluorobenzoxazole;5-Fluorobenzoxazole-2-thiol 97%;5-FLUOROBENZO[D]OXAZOLE-2-THIOL;5-Fluoro-2(3H)-benzoxazolethiene;5-Fluorobenzoxazole-2(3H)-thione;5-Fluorobenzoxazole-2-thiol, 97%,;2(3H)-Benzoxazolethione, 5-fluoro-;5-Fluorobenzoxazole-2-thiol;JR-8607, 5-Fluorobenzo[d]oxazole-2-thiol, 97%
CBNumber: CB4341448
Molecular Formula: C7H4FNOS
Formula Weight: 169.18
MOL File: 13451-78-0.mol

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5-FLUOROBENZO[D]OXAZOLE-2-THIOL Property

Melting point:: 238-240℃
Boiling point:: 238.8±42.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder
pka: 10.10±0.20(Predicted)
Appearance: Off-white to pink Solid
Sensitive: Moisture & Light Sensitive
CAS DataBase Reference: 13451-78-0

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39-24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 699969
Product name: 5-Fluorobenzoxazole-2-thiol
Purity: 97%
Packaging: 1g
Price: $72.1
Updated: 2023/06/20

TRC

Product number: F596108
Product name: 5-Fluoro-3H-1,3-benzoxazole-2-thione
Packaging: 500mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-W005135
Product name: 5-Fluorobenzo[d]oxazole-2-thiol
Purity: >98.0%
Packaging: 5g
Price: $88
Updated: 2021/12/16

Apolloscientific

Product number: PC904486
Product name: 5-Fluorobenzo[d]oxazole-2-thiol
Purity: 98%
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 098370
Product name: 5-Fluorobenzo[d]oxazole-2-thiol
Purity: 95+%
Packaging: 1g
Price: $114
Updated: 2021/12/16

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5-FLUOROBENZO[D]OXAZOLE-2-THIOL Chemical Properties,Usage,Production

Synthesis

75-15-0

399-97-3

13451-78-0

2-Amino-4-fluorophenol (10 g, 78.8 mmol), carbon disulfide (35 mL) and potassium hydroxide (5.3 g, 94.6 mmol) were mixed in ethanol (200 mL) and heated to reflux the reaction overnight. Upon completion of the reaction, the reaction mixture was concentrated to dryness and subsequently diluted with water. The diluted solution was neutralized with 1 M hydrochloric acid solution and then extracted several times with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and finally concentrated under vacuum to give 5-fluorobenzo[d]oxazole-2-thiol 9.3 g in 70% yield. The product was identified by 1H NMR (300MHz, DMSO-d6): δ7.51 (ddd, J=8.8,4.2,0.6Hz, 1H), 7.15-7.04 (m, 2H), 3.31 (brs, 1H). lC-MS (m/z): 170.2.

References

[1] Patent: WO2017/23941, 2017, A1. Location in patent: Page/Page column 50; 51
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 913 - 923
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 16, p. 3015 - 3021
[4] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 10, p. 3515 - 3523
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049

5-FLUOROBENZO[D]OXAZOLE-2-THIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-FLUOROBENZO[D]OXAZOLE-2-THIOL manufacturers

Honest Joy Holdings Limited

Product: 5-Fluorobenzo[d]oxazole-2-thiol 13451-78-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.2%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: 5-FLUOROBENZO[D]OXAZOLE-2-THIOL 13451-78-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-02-20

13451-78-0, 5-FLUOROBENZO[D]OXAZOLE-2-THIOLRelated Search:

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C7H4FNOS