ChemicalBook > CAS DataBase List > 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
- Product Name
- 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
- CAS No.
- 189005-44-5
- Chemical Name
- 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
- Synonyms
- Zolpidem Acid Impurity;Zolpidem Acid Impurity 2;Zolpidem Acid Impurity 1;Zolpidem Related Compound 5;6-Methyl-2-(4-Methylphenyl)Imi;e[1,2-a]-pyridine-3-acetic Acid;2-[6-Methyl-2-(4-methylphenyl)imida;6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]-;6-METHYL-2-(4-METHYLPHENYL)- IMIDAZO{1,2-A}PYRIDINE-3-;(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETIC ACID
- CBNumber
- CB4342445
- Molecular Formula
- C17H16N2O2
- Formula Weight
- 280.32
- MOL File
- 189005-44-5.mol
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6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Property
- Melting point:
- 243-245°C
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- form
- solid
- pka
- 2.87±0.10(Predicted)
- color
- Yellow
- CAS DataBase Reference
- 189005-44-5(CAS DataBase Reference)
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
TRC
- Product number
- M325903
- Product name
- ZolpidemAcid
- Packaging
- 2g
- Price
- $235
- Updated
- 2021/12/16
TRC
- Product number
- M325903
- Product name
- ZolpidemAcid
- Packaging
- 25g
- Price
- $1210
- Updated
- 2021/12/16
AK Scientific
- Product number
- J10667
- Product name
- ZolpidemRelatedCompound5
- Packaging
- 5mg
- Price
- $19
- Updated
- 2021/12/16
AK Scientific
- Product number
- J10667
- Product name
- ZolpidemRelatedCompound5
- Packaging
- 25mg
- Price
- $38
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- IM46256
- Product name
- 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
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6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Chemical Properties,Usage,Production
Chemical Properties
Off-White to Pale Beige Solid
Uses
An intermediate in the synthesis of Zolpidem.
Synthesis
82626-48-0
189005-44-5
Example 1a Synthesis of 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic acid: zolpidem (8.0 g, 26.0 mmol) was dissolved in 6N hydrochloric acid (80 mL) at 0°C and protected by argon with magnetic stirring. The reaction mixture was heated to reflux for 18 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the pH was adjusted to 6.5 by slowly adding 20% sodium hydroxide solution.The precipitated white solid was collected by vacuum filtration to afford the target product, 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic acid (6.9 g, 94% yield), as a white solid.1H NMR (DMSO-d6) δ 2.30 ( s, 3H), 2.35 (s, 3H), 3.94 (s, 2H), 7.10 (d, J = 9.1 Hz, 1H), 7.25 (d, J = 7.8 Hz, 2H), 7.48 (d, J = 9.1 Hz, 1H), 7.72 (d, J = 7.8 Hz, 2H), 8.18 (s, 1H).13C NMR (100 MHz, DMSO-d6) δ 18.4, 21.4, 30.8, 114.8, 116.6, 121.6, 122.9, 127.9, 128.2, 129.8, 132.4, 137.3, 143.0, 143.5, 171.8.
References
[1] Patent: WO2005/44818, 2005, A2. Location in patent: Page/Page column 18
6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid manufacturers
Jinan Million Pharmaceutical Co., Ltd
- Product
- 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid 189005-44-5
- Price
- US $1.00/kg
- Min. Order
- 0.10000000kg
- Purity
- 99%
- Supply Ability
- 200KG
- Release date
- 2024-10-18
Dingwang Technology (Wuhan) Co., Ltd.
- Product
- Zolpidic Acid 189005-44-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 TONS
- Release date
- 2022-11-08
Career Henan Chemical Co
- Product
- 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid 189005-44-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19
189005-44-5, 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acidRelated Search:
6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine
Triphenyltin acetate
1-Methylimidazole
2,6-Lutidine
4-Methylpyridine
Pyridine
2,4,6-Collidine
Ethyl 2-(Chlorosulfonyl)acetate
Imidazole
Azamethiphos
Bensulfuron methyl
Kresoxim-methyl
Methyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate
Tolyloyl propionamide
Thiophanate-methyl
6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
Methyl
Zolpidem tartrate Impurity 6