APAMIN

Product Name: APAMIN
CAS No.: 24345-16-2
Chemical Name: APAMIN
Synonyms: APAMIN;apamine;APAMIN, BEE VENOM;Apamin, ≥97% (HPLC);APAMIN FROM BEE VENOM;CNCKAPETALCARRCQQH-NH2;Ro 23-6721/Apamin TFA Salt;APAMIN FROM HONEY BEE VENOM;Apamin (trifluoroacetate salt);M.W. 2027.34 C79H131N31O24S4
CBNumber: CB4342708
Molecular Formula: C79H131N31O24S4
Formula Weight: 2027.34
MOL File: 24345-16-2.mol

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APAMIN Property

Boiling point:: 847.17°C (rough estimate)
Density: 1.63
refractive index: 1.5530 (estimate)
storage temp.: -20°C
solubility: 0.05 M acetic acid: 5 mg/mL, clear, colorless to faintly yellow
form: White solid with dark tan
color: White to off-white
biological source: synthetic
Water Solubility: Soluble to 1 mg/ml in water
Merck: 13,732

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Safety

Safety Statements: 22-24/25
RIDADR: 2811
WGK Germany: 3
RTECS: CD6899900
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 i.v. in mice: 4 mg/kg (Habermann, Reiz); LD50 intracerebroventricularly in mice: 12 ng/animal (Labbé-Jullié)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A1289
Product name: Apamin
Purity: from bee venom, ≥95% (HPLC)
Packaging: 0.5mg
Price: $298
Updated: 2024/03/01

Sigma-Aldrich

Product number: A9459
Product name: Apamin
Purity: synthetic, ≥97% (HPLC)
Packaging: 0.5mg
Price: $400
Updated: 2024/03/01

Sigma-Aldrich

Product number: 178270
Product name: Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem
Purity: Polypeptide neurotoxin known to pass through the blood-brain barrier.
Packaging: 500μg
Price: $182
Updated: 2024/03/01

Alfa Aesar

Product number: J60961
Product name: Apamin
Packaging: 0.5mg
Price: $168
Updated: 2021/12/16

Cayman Chemical

Product number: 17082
Product name: Apamin (trifluoroacetate salt)
Purity: ≥95%
Packaging: 500μg
Price: $160
Updated: 2024/03/01

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APAMIN Chemical Properties,Usage,Production

Chemical Properties

Small, highly potent, highly basic polypeptide.

Uses

Apamin has been used:

As a selective inhibitor of small conductance (SKCa) channels in HEK cells.
To inhibit endothelium-derived relaxing factor (EDHF) mediated responses.
To block small-conductance Ca₂-activated K current (ISK) in electrophysiological studies in hyperstriatum ventrale, pars caudalis (HVc) neurons.

Definition

Occurs in the venom of the honey bee, Apis mellifera; molecular weight of 2027.38.

General Description

Apamin is a bee venom component and is strongly basic in nature. It has 18 amino acid residues and two disulphide bonds.

Hazard

Central nervous system poison able to cross the blood–brain barrier; neurotoxic; poison.

Biochem/physiol Actions

Apamin is a neurotoxin which can pass the blood-brain barrier. In human, it might cause peripheral nerve dysfunction, mainly seen after bee stings.

Safety Profile

Poison by intravenous, parenteral,intracerebral, and intraperitoneal routes. When heated todecomposition it emits toxic fumes of SOx and NOx.

Enzyme inhibitor

This bee venom octadecapeptide toxin (FW = 2027.34 g/mol; CAS 24345- 16-2; NCBI Reference Sequence: NP_001011612.1) potently blocks the small-conductance Ca 2+ -activated potassium ion (or SK) channels hSK1 as well as rSK2, with IC50 values of 3.3 nM and 83 pM. It shows greater effectiveness at the SK2 channel (IC50 = 0.06-0.4 nM) than SK1 (IC50 = 1- 12 nM). SK3 (IC50 = 1-13 nM), and SK4 (IC50 = 1 μM) channels, and is active against channels within neurons, vascular endothelium, bladder smooth muscle, and certain cancers. Apamin does not inhibit human cardiac Na + current, L-type Ca 2+ current or other major K+ currents. Structurally, apamin forms a stable structure, consisting of a C-terminal a- helix and two reverse turns, that is stabilized by two disulfide bonds connecting Cys-1 to Cys-11 and Cys-3 to Cys-15. A minor constituent of venom of the bee (Apis mellifera), apamin amounts to only 2-3% (w/w) of its dry venom. The smallest known neurotoxic polypeptide, apamin is derived by proteolytic processing of the 48-residue pre-pro-protein. The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3'-exon.

storage

-20°C (desiccate)

APAMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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APAMIN Suppliers

China 113 France 2 Germany 3 India 4 Japan 2 Switzerland 2 United Kingdom 4 United States 24 Global 154

MedChemexpress LLC

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View Lastest Price from APAMIN manufacturers

Career Henan Chemical Co

Product: Apamin 24345-16-2
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

24345-16-2, APAMINRelated Search:

Glibenclamide Nicorandil CHARYBDOTOXIN TRAM-34 5-HYDROXYDECANOIC ACID SODIUM SALT CLOFILIUM TOSYLATE Gabapentin-lactam PAXILLINE N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE APAMIN Honey apamin receptor APAMIN, ALEXA FLUOR(R) 488 CONJUGATE APAMIN, BODIPY(R) FL CONJUGATE APAMIN (DRY ICE) Kca2.2, SK2, Kcnn2, SKCa2 (Apamin-Sensitive Small Conductance Ca2+ -dependent K+ Channel), Rabbit anti-Rat, WB/IH ANTI-POTASSIUM CHANNEL SK2 (APAMIN-SENSITIVE CONDUCTANCE CA2+-DEPENDENT K+ CHANNEL, KCA2, KCNN2, SKCA2) APAMIN, [125I]-HIS18-NH2

Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem

APAMIN (HONEYBEE, APIS MELLIFERA)

H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11, Cys3-Cys15)

H-+CYS-ASN-++CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-+CYS-ALA-ARG-ARG-++CYS-GLN-GLN- HIS-NH2

H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2

H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2 (DISULFIDE BRIDGE: 1-11, 3-15)

CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2

CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-CYS-GLN-GLN-HIS-NH2

[CYS-ASN-(CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS]CYCL-ALA-ARG-ARG-CYS)CYCL-GLN-GLN-HIS-NH2

CNCKAPETALCARRCQQH-NH2

CNCKAPETALCARRCQQH-NH2 (DISULFIDE BRIDGE: 1-11,3-15)

APAMIN

APAMIN, BEE VENOM

APAMIN (HONEY BEE, APIS MELIFERA)

apamine

APAMIN FROM BEE VENOM

APAMIN FROM HONEY BEE VENOM

Apamin, ≥97% (HPLC)

Apamin (trifluoroacetate salt)

M.W. 2027.34 C79H131N31O24S4

L-Cys-L-Asn-L-Cys-L-Lys-L-Ala-L-Pro-L-Glu-L-Thr-L-Ala-L-Leu-L-Cys-L-Ala-L-Arg-L-Arg-L-Cys-L-Gln-L-Gln-L-His-NH2

CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG- ARG-CYS-GLN-GLN-HIS-NH2(DISULFIDE BRIDGE:CYS1-CYS11, CYS3-CYS15)

L-Cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide cyclic (1-11) (3-15)-bis(disulfide) = Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-leu-Cyc-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2

Apamin, blocker of small conductance Ca2+-activated K+ channels

Ro 23-6721/Apamin TFA Salt

24345-16-2

C79H131N31O24S4

BioChemical

Amino Acids and Peptides

Biochemicals and Reagents

Cell Biology

Cell Signaling and Neuroscience

Monovalent Ion Channels

Other Peptides

Potassium Channel Modulators

Peptides

Ion Channels

Voltage-gated Ion Channels

Ion Channels

BeeVoltage-gated Ion Channels

Cell Signaling and Neuroscience

Ion Channel Modulating Peptides

Monovalent Ion Channels

Potassium Channel Modulators

Potassium Channel ModulatorsPeptides for Cell Biology

Toxins and Venoms

Potassium channel

Peptide